Asunto(s)
Linfoma Anaplásico de Células Grandes , Linfoma Anaplásico Cutáneo Primario de Células Grandes , Neoplasias Cutáneas , Fosfatasas de Especificidad Dual/genética , Reordenamiento Génico , Humanos , Linfoma Anaplásico de Células Grandes/genética , Linfoma Anaplásico de Células Grandes/patología , Linfoma Anaplásico Cutáneo Primario de Células Grandes/patología , Fosfatasas de la Proteína Quinasa Activada por Mitógenos/genética , Neoplasias Cutáneas/genética , Neoplasias Cutáneas/patologíaAsunto(s)
Rosácea/tratamiento farmacológico , Síndrome de Sweet/tratamiento farmacológico , Adulto , Fármacos Dermatológicos/administración & dosificación , Diagnóstico Diferencial , Exantema/diagnóstico , Exantema/tratamiento farmacológico , Cara , Glucocorticoides/administración & dosificación , Humanos , Masculino , Yoduro de Potasio/administración & dosificación , Prednisolona/administración & dosificación , Rosácea/patología , Síndrome de Sweet/patologíaAsunto(s)
Epididimitis/complicaciones , Pene/patología , Flebitis/diagnóstico , Tuberculosis Cutánea/diagnóstico , Tuberculosis de los Genitales Masculinos/complicaciones , Anciano de 80 o más Años , Epididimitis/microbiología , Epididimitis/cirugía , Humanos , Masculino , Mycobacterium tuberculosis/aislamiento & purificación , Orquiectomía , Pene/microbiología , Flebitis/microbiología , Flebitis/patología , Tuberculosis Cutánea/microbiología , Tuberculosis Cutánea/patología , Tuberculosis de los Genitales Masculinos/microbiología , Tuberculosis de los Genitales Masculinos/cirugíaAsunto(s)
Quimioradioterapia/métodos , Fraccionamiento de la Dosis de Radiación , Hemangiosarcoma/terapia , Neoplasias Inducidas por Radiación/terapia , Paclitaxel/uso terapéutico , Anciano de 80 o más Años , Mama/patología , Mama/efectos de la radiación , Neoplasias de la Mama/terapia , Diagnóstico Diferencial , Femenino , Hemangiosarcoma/diagnóstico , Hemangiosarcoma/etiología , Humanos , Mastectomía Segmentaria , Neoplasias Inducidas por Radiación/diagnóstico , Neoplasias Inducidas por Radiación/etiología , Radioterapia Adyuvante/efectos adversos , Sarcoma de Kaposi/diagnóstico , Piel/patología , Piel/efectos de la radiación , Resultado del TratamientoAsunto(s)
Adenocarcinoma Mucinoso/diagnóstico , Neoplasias del Recto/patología , Neoplasias Cutáneas/diagnóstico , Piel/patología , Adenocarcinoma Mucinoso/secundario , Adenocarcinoma Mucinoso/cirugía , Adulto , Nalgas , Diagnóstico Diferencial , Femenino , Humanos , Inmunohistoquímica , Neoplasias Cutáneas/secundario , Neoplasias Cutáneas/cirugíaRESUMEN
A 65-year-old Japanese man presented with a dome-shaped nodule, the base of which was contiguous with a dull brown plaque, on the left leg. After local excision of the cutaneous lesion and left inguinal lymph node dissection, several dermal and subcutaneous nodules developed successively on the left lower extremity. Hematoxylin-eosin staining of the primary cutaneous lesion demonstrated uniform neoplastic cells arranged in a trabecular pattern extending from the dermis to subcutis. Mitotic figures were abundant. Although the overlying epidermis was substantially intact, the Merkel cells had invaded the epidermis, resulting in Pautrier-like microabscesses. The hyperplastic epidermis adjacent to the nodule consisted of abnormally growing atypical keratinocytes. The enlarged left inguinal lymph node and successive secondary nodules contained Merkel cells similar to those in the primary nodule. Immunohistochemically, most tumor cells were positive for CAM5.2, synaptophysin, chromogranin A, CD56 and vimentin. The tumor cells in the left inguinal lymph node were positive for CAM5.2, synaptophysin and cytokeratin 20 but negative for CM2B4, and less than 1% of the cells expressed programmed cell death ligand 1. The patient was treated with avelumab, which showed significant efficacy against the in-transit recurrence. Two months later, all nodules had disappeared completely. We describe a case of in-transit recurrence of Merkel cell carcinoma that was associated histologically with Bowen's disease and was successfully treated with avelumab. Although accumulation of additional cases is needed, avelumab therapy may be a useful treatment for in-transit recurrence of Merkel cell carcinoma.
Asunto(s)
Anticuerpos Monoclonales/administración & dosificación , Enfermedad de Bowen/terapia , Carcinoma de Células de Merkel/terapia , Recurrencia Local de Neoplasia/tratamiento farmacológico , Neoplasias Cutáneas/terapia , Anciano , Anticuerpos Monoclonales Humanizados , Enfermedad de Bowen/patología , Carcinoma de Células de Merkel/patología , Procedimientos Quirúrgicos Dermatologicos , Esquema de Medicación , Humanos , Infusiones Intravenosas , Pierna , Masculino , Piel/patología , Neoplasias Cutáneas/patología , Resultado del TratamientoAsunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Leucemia-Linfoma Linfoblástico de Células Precursoras B/diagnóstico , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/tratamiento farmacológico , Biopsia , Dermoscopía , Cara , Femenino , Humanos , Lactante , Leucemia-Linfoma Linfoblástico de Células Precursoras B/tratamiento farmacológico , Leucemia-Linfoma Linfoblástico de Células Precursoras B/patología , Piel/diagnóstico por imagen , Piel/patología , Neoplasias Cutáneas/patología , Resultado del TratamientoAsunto(s)
Carcinoma Basocelular/patología , Carcinoma de Apéndice Cutáneo/diagnóstico , Neoplasias de las Glándulas Sudoríparas/diagnóstico , Glándulas Sudoríparas/patología , Anciano , Biomarcadores de Tumor/análisis , Carcinoma Basocelular/diagnóstico , Carcinoma de Apéndice Cutáneo/patología , Dermoscopía , Femenino , Humanos , Metaplasia/diagnóstico por imagen , Metaplasia/patología , Nariz , Neoplasias de las Glándulas Sudoríparas/patología , Glándulas Sudoríparas/diagnóstico por imagenAsunto(s)
Melanoma/diagnóstico , Nevo Pigmentado/diagnóstico , Nitrato de Plata , Neoplasias Cutáneas/diagnóstico , Coloración y Etiquetado/métodos , Adulto , Dermoscopía , Diagnóstico Diferencial , Femenino , Pie , Humanos , Melaninas/análisis , Melanoma/patología , Nevo Pigmentado/patología , Nevo Pigmentado/cirugía , Piel/diagnóstico por imagen , Piel/patología , Neoplasias Cutáneas/patología , Neoplasias Cutáneas/cirugíaRESUMEN
A 34-year-old Japanese man presented with an indolent nodule on the right flank. Computed tomography of the chest and abdomen demonstrated a large nodule measuring 55 mm × 50 mm in the abdominal oblique muscle layer of the right flank, and several small nodules were seen in the muscle layer throughout the body and subcutaneous tissue of the lower abdomen. 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography revealed nodular lesions in the bilateral parotid glands, bilateral cervical lymph nodes and lower lobe of the right lung. Intermittently, ground-glass shadows developed in the bilateral lungs. Histologically, sheet-like nodules in the abdominal oblique muscle layer and parotid gland were composed of large polygonal cells with convoluted nuclei and ample eosinophilic cytoplasm. Several lymphocytes and considerable eosinophils were intermingled. Lung biopsy demonstrated an inflammatory infiltrate of lymphocytes and considerable eosinophils in the alveoli. Immunohistochemically, polygonal cells were positive for S100 protein and CD1a, but negative for langerin and BRAFV600E . Some cells were positive for CD68. Electron microscopy demonstrated histiocytic cells with phagosomes and interdigitating processes. However, no Birbeck granules were observed. Eosinophilia was seen in the peripheral blood. Multifocal nodules and ground-glass shadows gradually diminished following systemic administration of oral prednisolone. We describe a case of indeterminate dendritic cell neoplasm with multifocal involvement of the muscle, subcutis, lymph node and parotid gland accompanied by chronic eosinophilic pneumonia that was successfully treated by systemic steroid therapy. Neither muscular nor parotid indeterminate dendritic cell neoplasms accompanied by eosinophilic pneumonia have been previously reported.
Asunto(s)
Histiocitosis de Células de Langerhans/patología , Células de Langerhans/patología , Músculo Esquelético/patología , Glándula Parótida/patología , Eosinofilia Pulmonar/diagnóstico por imagen , Neoplasias Cutáneas/patología , Adulto , Biopsia , Humanos , Pulmón/diagnóstico por imagen , Pulmón/patología , Ganglios Linfáticos/patología , Masculino , Eosinofilia Pulmonar/complicaciones , Eosinofilia Pulmonar/patología , Neoplasias Cutáneas/complicacionesRESUMEN
A 90-year-old Japanese woman presented with a dome-shaped, dark-red, ulcerated nodule measuring 23 mm × 19 mm × 9 mm on the right side of the nasal root. Histologically, anastomosing cord-like arrays of atypical polygonal keratinocytes exhibiting internal pseudolumina containing detached cells and erythrocytes were observed. Although acantholytic and cohesive areas overlapped, cancer pearls were not detected. The lower epidermis partially demonstrated scattered dyskeratotic and acantholytic keratinocytes with loss of polarity, continuous with an underlying tumor mass. The tumor cells were positive for a variety of cytokeratins, p40 and vimentin. The Ki-67 proliferation index was 50-60%. Both CD31 and CD34 were expressed in reactive blood vessels of the tumor. A local excision margined by 1 mm was performed, followed by X rays and electron beam irradiation. Neither lymph node nor distant metastasis has appeared over the 14 months since the excision. We performed a review of the published work and identified 24 previously reported patients with pseudovascular squamous cell carcinoma of the skin, oral mucosa and vulva to reassess the prognosis of this tumor. In 12 of these patients (50%), sites other than the head and neck were involved. Eight (33%) tumor-associated deaths occurred. It is believed that pseudovascular squamous cell carcinoma has a tendency to develop at morbid skin and mucous membranes sites in organs other than the face and neck and to possess an aggressive clinical behavior.
Asunto(s)
Carcinoma de Células Escamosas/patología , Neoplasias Cutáneas/patología , Anciano de 80 o más Años , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/cirugía , Epidermis/patología , Epidermis/cirugía , Femenino , Humanos , Nariz , Pronóstico , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/mortalidad , Neoplasias Cutáneas/cirugíaRESUMEN
A 45-year-old man was admitted because of necrolytic migratory erythema. A computed tomographic scan of the abdomen revealed a 4.5cm mass in the tail of the pancreas. We performed distal pancreatectomy and splenectomy, and a definitive diagnosis of pancreatic neuroendocrine tumor(WHO class grade 2)was made histopathologically.