RESUMEN
The experimental model of synchronous multiple primary malignant tumors (MPMT) was created. B16/F10 melanoma (0.5 ml of suspension diluted 1:20 in saline) and sarcoma 45 (0.5 million tumor cells in 0.5 ml saline) were simultaneously subcutaneously inoculated to male BALB/c nude mice. In the model of synchronous MPMT, the tumors appeared faster by 2.4 times and had greater volumes: melanoma by 2.2 times and sarcoma by 3.2 times; melanoma metastasized into sarcoma in 71.4% cases; the survival of mice with MPMT was lower. The altered dynamics of malignant growth in the MPMT model is based on the mutual influence of tumors, which results in the exchange of "structural information".
Asunto(s)
Neoplasias Pulmonares/patología , Melanoma Experimental/patología , Trasplante de Neoplasias/métodos , Neoplasias Primarias Múltiples/patología , Enfermedades de Inmunodeficiencia Primaria/patología , Neoplasias Cutáneas/patología , Animales , Línea Celular Tumoral , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/inmunología , Masculino , Melanoma Experimental/genética , Melanoma Experimental/inmunología , Ratones , Ratones Endogámicos BALB C , Ratones Desnudos , Neoplasias Primarias Múltiples/genética , Neoplasias Primarias Múltiples/inmunología , Enfermedades de Inmunodeficiencia Primaria/genética , Enfermedades de Inmunodeficiencia Primaria/inmunología , Ratas , Neoplasias Cutáneas/genética , Neoplasias Cutáneas/inmunologíaRESUMEN
A method for diagnostics of systolic function of the right ventricle of the heart in patients with cardiovascular disease is proposed. Its application expands possibilities for detecting disorders of the discharge RV function using a conventional pulsed wave Doppler ultrasonography.
