Interaction Effect of Psoriasis and Cancer on the Risk of All-Cause Mortality: A Prospective Cohort Study of NHANES Data.

Background: The relationship between psoriasis, cancer, and mortality has been reported in observational studies. Considering the high heterogeneity in systematic review and meta-analysis and inconsistent results in previous studies, the association between psoriasis, cancer, and mortality warrants more investigation. The primary objective of this study was to explore the joint impact of psoriasis and cancer on mortality in a representative cohort of adults residing in the United States. Methods: We analysed comprehensive data obtained from the National Health and Nutrition Examination Study conducted during the periods of 2003-2006 and 2009-2014. Multivariable logistic regression analyses were performed to assess the relationship between psoriasis and cancer. The vital status of participants was tracked until 31 December 2019. A four-level variable combining information on psoriasis and cancer was created, and survival probability was evaluated using the Kaplan-Meier curve and Cox regression analysis. Hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated to analyse the association between psoriasis/cancer and all-cause mortality. Results: In total, this study included 15,234 participants, among whom 418 had psoriasis and 1213 had cancer. The findings from the logistic regression analyses indicated a heightened risk of cancer among individuals with psoriasis in comparison to those without psoriasis. Moreover, the risk of skin cancer was higher in participants with psoriasis compared to those without psoriasis. Compared with individuals without cancer and psoriasis, the all-cause mortality HRs were 1.25 (95% CI: 0.87-1.78) for individuals with psoriasis only, 1.48 (95% CI: 1.20-1.82) for participants with cancer only, and 2.28 (95% CI: 1.12-4.63) for individuals with both psoriasis and cancer. Conclusion: The results of our study demonstrated a noteworthy and positive correlation between psoriasis, cancer, and all-cause mortality. These findings indicate that individuals who have both psoriasis and cancer face an increased likelihood of mortality.

Clinical Features and Skin Microbiome of Tinea Scrotum: An Observational Study of 113 Cases in China.

BACKGROUND: The scrotum is considered as an uncommon site for tinea, hence there is a lack of knowledge about the clinical characteristics, pathogenic agents and the skin microbiome changes of tinea scrotum. OBJECTIVE: We sought to analyze the clinical features, pathogenic agents and skin microbiome of tinea scrotum. METHODS: A two-center prospective observational study was carried out in outpatient dermatology clinics in Zhejiang, China, from September 2017 to September 2019. The diagnosis of tinea scrotum was confirmed by direct microscopy. Clinical and mycological data were collected. The composition of microbial communities of patients with tinea scrotum was analyzed and compared with healthy controls. RESULTS: A total of 113 patients with tinea scrotum were included. Tinea scrotum was either presented with isolated lesions (9/113, 8.0%) or accompanied by tinea of other sites (104/113, 92.0%). Tinea cruris was detected in 101 cases (89.38%). Fungal culture was positive in 63 cases, among which Trichophyton rubrum was grown in 60 cases (95.2%) and Nannizzia gypsea was cultured in 3 cases (4.8%). The skin microbiome in scrotum lesions from 18 patients showed increased abundance of Trichophyton compared with 18 healthy individuals, while Malassezia was decreased. No significant difference in bacterial diversity was found. CONCLUSIONS: Tinea scrotum was often companied by superficial fungal infections of other skin sites, with tinea cruris being the most common condition. Instead of N. gypsea, T. rubrum was the most frequently identified pathogen for tinea scrotum. In general, tinea scrotum exhibited changes in the fungal communities of the skin with increased Trichophyton and decreased Malassezia abundance.

Prevalence of Dermatitis and Superficial Fungal Infection of the Hands in Seafood Workers: An Investigation from Food Markets in Ningbo, China.

OBJECTIVE: Seafood workers have high risks of hand skin diseases. The purpose of this survey is to study the prevalence of occupational hand skin diseases in this population. METHODS: From March 2018 to October 2018, seafood workers in two food markets in Ningbo, China were investigated. Fungal microscopy and cultures from lesions on the hands and nails were performed. A community-based investigation of hand skin diseases was performed as a control group. RESULTS: One handred and eleven of 135 (82.2%) seafood workers in two food markets in Ningbo were taken into the investigation. The prevalence of hand dermatitis was 50.5% (56/111) in seafood workers, which is significantly higher than that of the control group (7.43%, p<0.001). It was found that the incidence of superficial fungal infection of the hands in seafood workers was much higher than that in community residents (26.1% vs 2.7%, p<0.001). Without wearing waterproof gloves, longer working time per day, longer history of seafood work increased the risk of hand dermatitis, instead of candidial infection of the hands and nails. CONCLUSION: Hand skin diseases are highly prevalent in seafood workers in Ningbo, a city in eastern China. This public health problem should be addressed in this population.