Effects of age, period, and cohort on mortality by prostate cancer among men in the state of Acre, in the Brazilian Western Amazon. / Efeitos de idade, período e coorte na mortalidade por câncer de próstata em homens no estado do Acre, oeste Amazônico brasileiro.

The present study aimed to analyze the effects of age, time period, and birth cohort on the temporal evolution of mortality rates due to prostate cancer in men from the state of Acre, Brazil, in the period of 1990 to 2019. This is an ecological study in which the temporal trend was evaluated by the joinpoint method, estimating the annual percentage variations of the mortality rates. The age-period-birth cohort effects were calculated by using the Poisson Regression method, using estimation functions. The mortality rates showed an increase of 2.20% (95%CI: 1.00-3.33) in the period studied, tended to increase with age. A relative risk (RR) of 0.67 (95%CI: 0.59-0.76) was observed between 2005 and 2009, 0.76 (95%CI: 0.67-0.87) from 2005 on, and 1.44 (95%CI: 1.25-1.68) from 2015 on. The cohorts from 1910 to 1924 presented a risk reduction (RR < 1), when compared to the reference cohort (1935). Regarding the time period, the creation of public policies and the establishment of guidelines are suggested as factors which may have contributed to more access to diagnosis, in consonance with the cohort effect. These findings can contribute to a better understanding of the epidemiological scenario of prostate cancer in regions that are more vulnerable in terms of socioeconomic conditions.

O objetivo foi analisar os efeitos de idade, período e coorte de nascimento na evolução temporal da mortalidade por câncer de próstata em homens no estado do Acre, no período de 1990 a 2019. Trata-se de um estudo ecológico de tendência temporal, que foi avaliada pelo método de joinpoint, estimando as variações percentuais anuais das taxas de mortalidade. Os efeitos idade-período-coorte de nascimento foram calculados pelo modelo de regressão de Poisson, utilizando as funções estimáveis. A taxa de mortalidade apresentou incremento de 2,20% (IC95%: 1,00-3,33) no período estudado. A mortalidade aumentou com a idade. Foi observado risco relativo (RR) de 0,67 (IC95%: 0,59-0,76) entre 2005 e 2009, de 0,76 (IC95%: 0,67-0,87) a partir de 2005 e de 1,44 (IC95%: 1,25-1,68) a partir de 2015. As coortes de 1910 a 1924 apresentaram redução do risco (RR < 1) quando comparadas à coorte de referência (1935). Quanto ao período, sugere-se que a instituição de políticas públicas e o estabelecimento de diretrizes podem ter auxiliado para maior acesso ao diagnóstico, em consonância com o efeito de coorte. Esses achados contribuem para melhor compreensão do cenário epidemiológico do câncer de próstata em regiões com condições socioeconômicas mais vulneráveis.

Blood levels of metallic chemical element exposure patterns and associated factors in a population living in an Industrial District in Brazil.

AIM: to estimate the level of metallic chemical elements in the population living in the Steel company vicinity in Santa Cruz, Rio de Janeiro, Brazil; and estimate the association between exposure to the Steel company and the blood metals concentrations patterns. METHOD: A cross-sectional study was carried out on 463 individuals aged 18+ years old residing 1+ years in the Steel company vicinity. Mg, Be, Co, Ba, Ni, Cd, Al, and Pb were assessed in blood by DRC-ICP-MS. Metallic chemical element concentration patterns were obtained by exploratory factor analysis in the studied population. Exposure was set as the distance (Km) from each participant's residence to the Steel company in Santa Cruz, georeferenced by GPS. The outcome was set as the positive factor loadings in the factor analysis, including Mg and Be (Factor-1), Co, Ba, and Ni (Factor-2), Cd, Al, and Pb (Factor-4). Crude and adjusted OR, and their respective 95 %CI, were estimated to explore associations between independent variables and the exposures to metallic elements positively associated with the factors using polychotomous logistic regression. RESULTS: A reduction of 19 % was found between each km distance from the residence and the Steel company and P50 concentration of Cd, Al, and Pb (ORP50=0.81; 95 %CI:0.67-0.97), after adjusting by age, sex, and smoking. No statistically significant associations were observed for the distance from residences and the Steel company, after adjusting for age, gender, having a domestic vegetable garden and chewing gum for Mg and Be concentrations (Factor-1) (ORP50=0.84; 95 %CI:0.70-1.01; ORP75=1.10; 95 %CI:0.91-1.34); nor for Co, Ba and Ni (Factor-2) blood concentrations(ORP50=1.10; 95 %CI:0.91-1.33; ORP75=1.03; 95 %CI:0.84-1.26), in the adjusted analysis. CONCLUSIONS: For each Km distance from residences to the Steel company, a 19 % reduction in the risk of Cd, Al, and Pb blood concentration was observed in the population living in Santa Cruz, Rio de Janeiro, Brazil.

Influence of non-pharmacological methods on duration of labor: a systematic review / A influência de métodos não farmacológicos na duração do parto: uma revisão sistemática

Abstract The article aims to verify the influence of MNFs on the duration of the birth process. A systematic review was carried out in the MEDLINE, Web of Science and LILACS databases, through a combination of terms that cover the topic addressed, from 1996 to 2021/April. The Excel spreadsheet was used to collect data to extract information regarding each selected article, in turn, data analysis included the evaluation and classification of quality, reliability and risk of bias, thus, the following tools were used: Cochrane RoB 2, Checklist and Newcastle-Ottawa Scale. Warm bath, walking, exercises with a birthing ball, breathing techniques, supine position, acupuncture, acupressure and water birth reduced labor time. While spontaneous pushing, massage and immersion baths prolonged labor. Non-pharmacological methods capable of reducing the duration of labor were hot/warm shower, walking, birth ball exercises, breathing techniques, maternal mobility, dorsal position, acupuncture, acupressure and water birth, as well. associated applied techniques such as hot/warm bath, ball exercises and lumbosacral massage, as well as immersion bath, ball exercises, aromatherapy, vertical postures and maternal mobility with alternating vertical postures, shortened the birth time.

Resumo O objetivo do artigo é verificar a influência dos MNFs na duração do processo de parto. Realizou-se uma revisão sistemática nas bases de dados MEDLINE, Web of Science e LILACS, por meio da combinação de termos que contemple a temática abordada, no período de 1996 a 2021/abril. Utilizou-se para coleta de dados a planilha Excel para extração de informações referentes a cada artigo selecionado, por sua vez, a análise dos dados compreendeu a avaliação e classificação da qualidade, confiabilidade e risco de viés, assim, utilizou-se como ferramentas: Cochrane RoB 2, Checklist e Escala de Newcastle-Ottawa. Reduziram o tempo de trabalho de parto banho morno, caminhada, exercícios com bola de parto, técnicas respiratórias, decúbito dorsal, acupuntura, acupressão e parto na água. Enquanto empurrões espontâneos, massagem e banho de imersão prolongaram o trabalho de parto. Os métodos não farmacológicos capazes de reduzir a duração do trabalho de parto foram banho de chuveiro quente/morno, caminhada, exercícios com bola de parto, técnicas de respiração, mobilidade materna, posição dorsal, acupuntura, acupressão e parto na água, também encurtaram o tempo de parto técnicas aplicadas associadas como banho quente/morno, exercícios com bola e massagem lombossacral, assim como banho de imersão, exercícios com bola, aromaterapia, posturas verticais e mobilidade materna com posturas verticais alternadas.

Influence of non-pharmacological methods on duration of labor: a systematic review.

The article aims to verify the influence of MNFs on the duration of the birth process. A systematic review was carried out in the MEDLINE, Web of Science and LILACS databases, through a combination of terms that cover the topic addressed, from 1996 to 2021/April. The Excel spreadsheet was used to collect data to extract information regarding each selected article, in turn, data analysis included the evaluation and classification of quality, reliability and risk of bias, thus, the following tools were used: Cochrane RoB 2, Checklist and Newcastle-Ottawa Scale. Warm bath, walking, exercises with a birthing ball, breathing techniques, supine position, acupuncture, acupressure and water birth reduced labor time. While spontaneous pushing, massage and immersion baths prolonged labor. Non-pharmacological methods capable of reducing the duration of labor were hot/warm shower, walking, birth ball exercises, breathing techniques, maternal mobility, dorsal position, acupuncture, acupressure and water birth, as well. associated applied techniques such as hot/warm bath, ball exercises and lumbosacral massage, as well as immersion bath, ball exercises, aromatherapy, vertical postures and maternal mobility with alternating vertical postures, shortened the birth time.

Efeitos de idade, período e coorte na mortalidade por câncer de próstata em homens no estado do Acre, oeste Amazônico brasileiro / Effects of age, period, and cohort on mortality by prostate cancer among men in the state of Acre, in the Brazilian Western Amazon

Resumo O objetivo foi analisar os efeitos de idade, período e coorte de nascimento na evolução temporal da mortalidade por câncer de próstata em homens no estado do Acre, no período de 1990 a 2019. Trata-se de um estudo ecológico de tendência temporal, que foi avaliada pelo método de joinpoint, estimando as variações percentuais anuais das taxas de mortalidade. Os efeitos idade-período-coorte de nascimento foram calculados pelo modelo de regressão de Poisson, utilizando as funções estimáveis. A taxa de mortalidade apresentou incremento de 2,20% (IC95%: 1,00-3,33) no período estudado. A mortalidade aumentou com a idade. Foi observado risco relativo (RR) de 0,67 (IC95%: 0,59-0,76) entre 2005 e 2009, de 0,76 (IC95%: 0,67-0,87) a partir de 2005 e de 1,44 (IC95%: 1,25-1,68) a partir de 2015. As coortes de 1910 a 1924 apresentaram redução do risco (RR < 1) quando comparadas à coorte de referência (1935). Quanto ao período, sugere-se que a instituição de políticas públicas e o estabelecimento de diretrizes podem ter auxiliado para maior acesso ao diagnóstico, em consonância com o efeito de coorte. Esses achados contribuem para melhor compreensão do cenário epidemiológico do câncer de próstata em regiões com condições socioeconômicas mais vulneráveis.

Abstract The present study aimed to analyze the effects of age, time period, and birth cohort on the temporal evolution of mortality rates due to prostate cancer in men from the state of Acre, Brazil, in the period of 1990 to 2019. This is an ecological study in which the temporal trend was evaluated by the joinpoint method, estimating the annual percentage variations of the mortality rates. The age-period-birth cohort effects were calculated by using the Poisson Regression method, using estimation functions. The mortality rates showed an increase of 2.20% (95%CI: 1.00-3.33) in the period studied, tended to increase with age. A relative risk (RR) of 0.67 (95%CI: 0.59-0.76) was observed between 2005 and 2009, 0.76 (95%CI: 0.67-0.87) from 2005 on, and 1.44 (95%CI: 1.25-1.68) from 2015 on. The cohorts from 1910 to 1924 presented a risk reduction (RR < 1), when compared to the reference cohort (1935). Regarding the time period, the creation of public policies and the establishment of guidelines are suggested as factors which may have contributed to more access to diagnosis, in consonance with the cohort effect. These findings can contribute to a better understanding of the epidemiological scenario of prostate cancer in regions that are more vulnerable in terms of socioeconomic conditions.

Stomach cancer incidence trends in selected Latin America countries: Age, period, and birth-cohort effects.

BACKGROUND: to explore the age, period, and birth-cohort effects on stomach cancer incidence trends during 3 decades in selected Latin American countries. METHODS: a time-trend study was performed using Cancer Incidence in Five Continents data from high-quality population-based cancer registries(PBCRs) in Latin American countries. Crude and age-standardized incidence rates(ASRIs) were calculated. Time trends in ASRIs were assessed using the average annual percentage change(AAPC). Age-period-cohort effects were estimated by Poisson regression for individuals aged between 20 and 79 years with stomach cancer informed by PBCRs from 1983 to 2012 in Cali(Colombia); from 1982 to 2011 in Costa Rica; and from 1988 to 2012 for Goiania(Brazil) and Quito(Ecuador). The goodness-of-fit model was tested using the deviance of the models. RESULTS: a decrease in age-standardized incidence rates was observed for both genders in all populations covered by PBCRs, except for young men from Cali(AAPC 3.89 95 %IC: 1.32-7.29). The age effect was statistically significant in all areas, and the curve slope reached peaks in the older age groups. The cohort effect was observed in all PBCRs. Regarding the period effect, an increased ratio rate was observed for both genders in Costa Rica(1997-2001 women RR 1.11 95 %CI: 1.05-1.17; men RR 1.12 95 %CI: 1.08-1.17) and Goiânia(2003-2007 women RR 1.21 95 %CI: 1.08-1.35; men RR 1.09 95 %CI: 1.01-1.20), while Quito(1998-2002 women RR 0.89 95 %CI: 0.81-0.98; men RR 0.86 95 %CI: 0.79-0.93) presented a decrease. CONCLUSION: the present study showed a decreasing gastric cancer trend for over the past 30 years with gender and geographic variations. Such a decrease seems to be mainly a result of cohort effects, suggesting that the economic market opening process led to changes in the risk factor exposures over successive generations. These geographic and gender variations may reflect cultural/ethnic/gender differences and differences in dietary and smoking rate patterns. However, an increased incidence was observed for young men in Cali, and additional studies are needed to determine the cause of the increasing incidence in this group.

Caracterização dos Casos de Câncer de Cavidade Oral e Faringe da Região Norte do Brasil, 2012-2015 / Characterization of Oral Cavity and Pharyngeal Cancer Cases in Northern Brazil, 2012-2015 / Caracterización de Casos de Cáncer de Cavidad Oral y Faringe en el Norte de Brasil, 2012-2015

Introdução: O câncer de cavidade oral e faringe é um problema de saúde pública, apresentando elevadas taxas de incidência e mortalidade. Objetivo: Caracterizar o perfil clínico-epidemiológico e os atrasos no diagnóstico e tratamento de casos atendidos nas unidades de referência da Região Norte do Brasil. Método: Estudo descritivo dos casos de câncer de cavidade oral e faringe registrados nas bases de dados dos Registros Hospitalares de Câncer (RHC) de 2012 a 2015. Foram analisados os intervalos entre a primeira consulta e o diagnóstico, e o diagnóstico e o tratamento. As variáveis contínuas foram avaliadas por meio de medidas de tendência central e de dispersão. As diferenças entre proporções nas variáveis categóricas foram avaliadas pelo teste qui-quadrado, considerando-se o nível de significância de 5%. Resultados: Entre os homens, os casos de orofaringe foram mais incidentes (19,2%) e nas mulheres os mais incidentes (16,3%) de outras partes e partes não especificadas da língua. A maior parte dos casos era de homens, cor parda, >60 anos, sem cônjuge, com escolaridade até o nível fundamental. O carcinoma de células escamosas foi o mais comum. Com relação ao tempo, 69,6% dos casos que chegaram ao hospital sem diagnóstico e sem tratamento foram diagnosticados até 30 dias após a primeira consulta, e 67,8% dos casos receberam o primeiro tratamento em até 60 dias. Conclusão: A maioria dos casos analisados apresentou tempo de diagnóstico dentro do prazo recomendado, porém foi observado que os casos com diagnóstico e sem tratamento demoraram mais de 60 dias

Introduction: Oral cavity and pharyngeal cancer is a public health problem with high incidence and mortality rates. Objective: To characterize the clinical-epidemiological profile and delays in diagnosis and treatment of cases of oral cavity and pharyngeal cancer treated in reference units in Brazil's North Region. Method: Descriptive study of oral cavity and pharyngeal cancer registered in the Hospital-based Cancer Registry (HBCR) in the North Region from 2012 to 2015. The intervals between the 1st consultation and diagnosis and diagnosis and treatment were analyzed. Continuous variables were evaluated using measures of central tendency and dispersion. Differences between proportions in categorical variables were assessed using the chi square test, considering a significance level of 5%. Results: Among men, cases of oropharynx were more incidents (19.2%) and in women, the most incidents (16.3%) were from other parts and unspecified parts of the tongue. Most of the cases were males, brown, >60 years old, without spouse and elementary education. Squamous cell carcinoma was the most common. 69.6% of cases that arrived at the hospital without diagnosis and without treatment were diagnosed within 30 days after the 1st consultation and 67.8% of cases received the 1st treatment within 60 days. Conclusion: Most of the cases analyzed were diagnosed within the recommended timeframe. However, cases with diagnosis and without treatment took more than 60 days

Introducción: El cáncer de cavidad oral y faringe es un problema de salud pública, con altas tasas de incidencia y mortalidad. Objetivo: Caracterizar el perfil clínico-epidemiológico y las demoras en el diagnóstico y tratamiento de los casos de cáncer de cavidad oral y faringe atendidos en unidades de referencia del Norte de Brasil. Método: Se realizó un estudio descriptivo de los casos analíticos de cáncer de cavidad oral y faringe registrados en las bases de datos del Registros Hospitalarios de Cáncer (RHC) en la Región Norte de 2012 a 2015. Se analizaron los intervalos entre la primera consulta y el diagnóstico y diagnóstico y tratamiento. Las variables continuas se evaluaron mediante medidas de tendencia central y dispersión. Las diferencias entre proporciones en variables categóricas se evaluaron mediante la prueba chi cuadrado, considerando un nivel de significancia del 5%. Resultados: Entre los hombres, los casos de orofaringe fueron más incidentes (19,2%) y entre las mujeres los de otras partes y partes no especificadas del idioma fueron los más incidentes (16,3%). La mayoría de los casos fueron del sexo masculino, moreno, >60 años, sin pareja, con educación hasta el nivel elemental. El carcinoma de células escamosas fue el más común. En cuanto al tiempo, el 69,6% de los casos que llegaron al hospital sin diagnóstico y sin tratamiento fueron dentro de los 30 días posteriores a la primera consulta y el 67,8% de los casos recibieron el 1er tratamiento dentro de los 60 días. Conclusión: La mayoría de los casos analizados presentaron tiempo de diagnóstico dentro del período recomendado. Sin embargo, se observó que los casos con diagnóstico y sin tratamiento demoran más de 60 días

Axillary surgical approach in T1-T2N0M0 clinical breast cancer staging: Survival in a women's hospital cohort in Rio de Janeiro

The concerns regarding the prognosis and quality of life of patients with early breast cancer staging without lymph node involvement have increased, especially with regard to the axillary surgical approach. The aim of the present study was to determine overall survival and disease-free survival according to the axillary surgical approach. Methods: Retrospective cohort study of 827 women with clinical T1-T2N0M0 diagnosis attended at the Cancer Hospital III of the Brazilian National Cancer Institute, from January 2007 to December 2009, with a follow-up period of 60 months. Data were obtained from the Hospital Registry of Cancer through the medical records. Results: 683 women underwent sentinel lymph node biopsy and 144 underwent sentinel lymph node biopsy followed by axillary lymphadenectomy. After 5 years of follow-up, considering adjustment, it was observed overall survival (96.2% vs 93.6%; HR 0.98; 95%CI 0.42­2.29) and disease-free survival (93.7% vs 91.2%; HR 0.78; 95%CI 0.39­1.48) similar among patients undergoing either one or the other approach. In patients with micrometastasis, both overall (93.3%) and diseasefree survival (100%) were higher in women who underwent only sentinel lymph node biopsy compared to those who underwent this procedure followed by axillary lymphadenectomy (OS: 87.5%; DFS: 90,7%), albeit not statistically significant.

Time trends in colorectal cancer incidence in four regions of Latin America: 1983-2012.

This study aimed to assess time trends in colorectal cancer incidence from 1983 to 2012 in Latin America. This was an ecological time-series study whose population consisted of individuals aged 20 years or older diagnosed with colorectal cancer. Data from population-based cancer registries in Cali (Colombia), Costa Rica, Goiânia (Brazil), and Quito (Ecuador), were used for rates estimation, while time trends estimations were proceeded by the Joinpoint Regression Program. The study showed an increase in colorectal cancer incidence in men and women in Cali (2.8% and 3.2%, respectively), Costa Rica (3.1% and 2.1%, respectively), and Quito (2.6% and 1.2%, respectively), whereas in Goiânia, only women showed an increase in colorectal cancer rates (3.3%). For colon cancer, we observed an increasing trend in incidence rates in men and women in Cali (3.1% and 2.9%, respectively), Costa Rica (3.9% and 2.8%, respectively), and Quito (2.9% and 1.8%). For rectal cancer, we observed an increasing trend in incidence in men and women in Cali (2.5% and 2.6%, respectively), Costa Rica (2.2% and 1%, respectively), and Goiânia (5.5% and 4.6%, respectively), while in Quito only men showed an upward trend (2.8%). The study found increases in colorectal cancer, colon cancer, and rectal cancer in four Latin America regions. This findings reflect lifestyle, such as dietary changes, following the economic opening, and the prevalence variations of colorectal cancer risk factors by sex and between the four studied regions. Finally, the different strategies adopted by regions for colorectal cancer diagnosis and screening seem to influence the observed variation between anatomical sites.

[Exposure to metals in the adult population living in industrial areas: a systematic review of the literature]. / Exposição a metais em população adulta residente em áreas industriais: revisão sistemática da literatura.

This study aimed to review studies of human biomonitoring (HBM) that evaluated exposure to lead (Pb), cadmium (Cd), mercury (Hg), nickel (Ni), arsenic (As) and manganese (Mn) in adults living close to industrial areas. A systematic review of studies was selected, without initial date limit through to December 2017, from the MEDLINE and BVS databases. Original studies in English, Portuguese or Spanish conducted among the adult population using blood and/or urine as biomarkers were included. The articles were evaluated according to methodological criteria, including studies with comparison groups and/or probabilistic sampling. Of the 28 studies selected, 54% were conducted in Europe, 36% in Asia, 7% in North America and 4% in Africa. Foundries, metal works and steel mills were the most frequently studied. Urine and blood were used in 82% and 50% of studies, respectively. The elements most investigated were Cd, Pb and As. Despite using heterogeneous methodologies, the results revealed higher metal concentrations, especially from As and Hg in general, than in the comparison group. This review highlights the need for more rigorous methodological studies of HBM, stressing the importance of public health vigilance among populations exposed to toxic metals, especially in developing countries.

Este artigo objetivou revisar os estudos de biomonitoramento humano (BMH) que avaliaram a exposição a chumbo (Pb), cádmio (Cd), mercúrio (Hg), níquel (Ni), arsênio (As) e manganês (Mn) em adultos residentes próximo a áreas industriais. Realizou-se uma revisão sistemática, sem limite de data inicial até dezembro de 2017, utilizando a base de dados da MEDLINE e a BVS. Foram incluídos estudos originais em inglês, português ou espanhol, com uso de sangue e/ou urina como biomarcador. Os artigos foram avaliados pelos critérios metodológicos, incluindo-se estudos com grupo de comparação e/ou amostragem probabilística. Dos 28 estudos incluídos, 54% foram realizados na Europa, 36% na Ásia, 7% na América do Norte e 4% na África. Fundições, metalúrgicas e siderúrgicas foram as indústrias mais estudadas. Urina e sangue foram usados em 82% e 50% dos estudos, respectivamente. Os elementos mais investigados foram Cd, Pb e As. Embora com metodologias heterogêneas, em geral, os estudos observaram maiores concentrações de metais em expostos, especialmente As e Hg, do que nos grupos de comparação. Esta revisão evidencia a necessidade de estudos de BMH com maior rigor metodológico, reforçando a importância da vigilância em saúde de populações expostas a metais tóxicos, sobretudo nos países em desenvolvimento.

Breastfeeding patterns and factors associated with early weaning in the Western Amazon.

OBJECTIVE: To characterize breastfeeding patterns in the first six months of life and factors associated with early weaning in a birth-cohort in Rio Branco, state of Acre. METHODS: This is a prospective study with all babies born between April and June 2015. The mothers were interviewed soon after birth and between 6 and 15 months postpartum. At hospital discharge, breastfeeding was defined as exclusively (EBF), and breastfeeding (BF). In the follow-up, breastfeeding patterns were exclusive breastfeeding (EBF), predominant breastfeeding (PBF), and breastfeeding (BF). The interruption of breastfeeding in the first six months was classified as early weaning. The Kaplan Meier method (log-rank: 95%) was used to estimate the conditional probability of change in breastfeeding pattern, and early weaning risk. Crude and adjusted proportional Cox regression models, and their respective 95% confidence intervals (95%CI), were used to analyze the factors associated with early weaning. RESULTS: The study included 833 infants in EBF (95.4%) and BF (4.6%) at hospital discharge. During the first six months of life, the infant likely discharged in EBF remaining in EBF, becoming PBF, and BF, were respectively 16.4%, 32.3%, and 56.5%. The weaning likely at six months was statistically higher for infants discharged in BF (47.4%) when compared with those discharged in EBF (26%). Factors associated with early weaning were BF at hospital discharge (HR = 1.82; 95%CI 1.06-3.11), no mother cross-breastfeeding (HR = 2.50; 95%CI 1.59-3.94), pacifier use (HR = 6.23; 95%CI 4.52-8.60), less than six months of breastfeeding intention (HR = 1.93; 95%CI 1.25-2.98), lack of breastfeeding in the first hour of life (HR = 1.45; 95%CI 1.10-1.92), and pregnancy alcohol consumption (HR = 1.88; 95%CI 1.34-2.90). CONCLUSION: Compared to infants in EBF, those in BF at hospital discharge were more likely to wean. Public health efforts should prioritize EBF at hospital discharge, promote breastfeeding in the first hour of life, and prevent alcohol consumption risks during pregnancy, cross-breastfeeding and pacifier use.

Time trends in colorectal cancer incidence in four regions of Latin America: 1983-2012 / Tendências temporais na incidência do câncer colorretal em quatro regiões da América Latina: 1983-2012 / Tendencias temporales en la incidencia del cáncer colorrectal en cuatro regiones latinoamericanas: 1983-2012

Abstract: This study aimed to assess time trends in colorectal cancer incidence from 1983 to 2012 in Latin America. This was an ecological time-series study whose population consisted of individuals aged 20 years or older diagnosed with colorectal cancer. Data from population-based cancer registries in Cali (Colombia), Costa Rica, Goiânia (Brazil), and Quito (Ecuador), were used for rates estimation, while time trends estimations were proceeded by the Joinpoint Regression Program. The study showed an increase in colorectal cancer incidence in men and women in Cali (2.8% and 3.2%, respectively), Costa Rica (3.1% and 2.1%, respectively), and Quito (2.6% and 1.2%, respectively), whereas in Goiânia, only women showed an increase in colorectal cancer rates (3.3%). For colon cancer, we observed an increasing trend in incidence rates in men and women in Cali (3.1% and 2.9%, respectively), Costa Rica (3.9% and 2.8%, respectively), and Quito (2.9% and 1.8%). For rectal cancer, we observed an increasing trend in incidence in men and women in Cali (2.5% and 2.6%, respectively), Costa Rica (2.2% and 1%, respectively), and Goiânia (5.5% and 4.6%, respectively), while in Quito only men showed an upward trend (2.8%). The study found increases in colorectal cancer, colon cancer, and rectal cancer in four Latin America regions. This findings reflect lifestyle, such as dietary changes, following the economic opening, and the prevalence variations of colorectal cancer risk factors by sex and between the four studied regions. Finally, the different strategies adopted by regions for colorectal cancer diagnosis and screening seem to influence the observed variation between anatomical sites.

Resumo: O estudo teve como objetivo avaliar as tendências temporais na incidência do câncer colorretal entre 1983 e 2012 na América Latina. Este é um estudo ecológico de séries temporais com uma população de indivíduos com 20 anos ou mais, diagnosticados com câncer colorretal. Foram usados os dados dos registros de câncer de base populacional de Cáli (Colômbia), Costa Rica, Goiânia (Brasil) e Quito (Equador) para estimar taxas, enquanto as estimativas das tendências temporais foram realizadas com o software Joinpoint Regression Program. O estudo mostrou um aumento na incidência do câncer colorretal em homens e mulheres em Cáli (2,8% e 3,2%, respectivamente), Costa Rica (3,1% e 2,1%, respectivamente) e Quito (2,6% e 1,2%, respectivamente). Em Goiânia, somente as mulheres mostraram um aumento na incidência do câncer colorretal (3,3%). Para o câncer de cólon, houve uma tendência crescente na incidência em homens e mulheres em Cali (3,1% e 2,9%, respectivamente), Costa Rica (3,9% e 2,8%, respectivamente) e Quito (2,9% e 1,8%). Para o câncer retal, houve uma tendência crescente na incidência em homens e mulheres em Cali (2,5% e 2,6%, respectivamente), Costa Rica (2,2% e 1%, respectivamente) e Goiânia (5,5% e 4,6%, respectivamente), enquanto em Quito somente os homens mostraram tendência crescente (2,8%). O estudo encontrou aumentos no câncer colorretal, câncer de cólon e câncer retal em quatro regiões latino-americanas. Os achados refletem mudanças no estilo de vida, como mudanças de dieta, após a abertura econômica, e variações na prevalência de fatores de risco para câncer colorretal de acordo com gênero e entre as quatro regiões estudadas. Finalmente, as diferentes estratégias adotadas pelas regiões para o diagnóstico e triagem do câncer colorretal parecem influenciar a variação observada entre os sítios anatômicos.

Resumen: El objetivo fue evaluar las tendencias temporales en la incidencia del cáncer colorrectal, de 1983 a 2012, en Latinoamérica. Se trata de un estudio ecológico de series temporales, cuya población consistió en individuos con 20 años de edad, diagnosticados con cáncer colorrectal. Para las tasas de estimación se utilizaron los datos provenientes de los registros de cáncer de base poblacional en: Cali (Colombia), Costa Rica, Goiânia (Brasil), y Quito (Ecuador), mientras que las estimaciones en las tendencias temporales se obtuvieron mediante el software Joinpoint Regression Program. El estudio mostró un incremento en la incidencia de cáncer colorrectal en hombres y mujeres en Cali (2.8% y 3.2%, respectivamente), Costa Rica (3.1% y 2.1%, respectivamente), y Quito (2.6% y 1.2%, respectivamente). En Goiânia, solo las mujeres mostraron un incremento en las tasas de cáncer colorrectal (3.3%). Para el cáncer de colon, hubo una tendencia creciente en las tasas de incidencia en hombres y mujeres en Cali (3.1% y 2.9%, respectivamente), Costa Rica (3.9% y 2.8%, respectivamente), y Quito (2.9% y 1.8%). En el caso del cáner rectal, hubo una tendencia creciente en la incidencia en hombres y mujeres en Cali (2.5% y 2.6%, respectivamente), Costa Rica (2.2% y 1%, respectivamente), y Goiânia (5.5% y 4.6%, respectivamentre), mientras en Quito solo los hombres mostraron una tendencia creciente (2.8%). El estudio encontró incrementos en cáncer colorrectal, cáncer de colon, y cáncer rectal en cuatro regiones de Latinoamérica. Los resultados reflejan un estilo de vida con cambios en la dieta, que siguió a la apertura económica, así como variaciones en la prevalencia de los factores de riesgo de cancer colorrectal por sexos y entre las cuatro regiones estudiadas. Finalmente, las diferentes estrategias adoptadas por las regiones para el diagnóstico del cáncer colorrectal y su pruebas de cribado parece que influencian la variación observada entre los sitios anatómicos donde surge.

Breastfeeding patterns and factors associated with early weaning in the Western Amazon / Padrões de amamentação e fatores associados ao desmame precoce na Amazônia ocidental

ABSTRACT OBJECTIVE: To characterize breastfeeding patterns in the first six months of life and factors associated with early weaning in a birth-cohort in Rio Branco, state of Acre. METHODS: This is a prospective study with all babies born between April and June 2015. The mothers were interviewed soon after birth and between 6 and 15 months postpartum. At hospital discharge, breastfeeding was defined as exclusively (EBF), and breastfeeding (BF). In the follow-up, breastfeeding patterns were exclusive breastfeeding (EBF), predominant breastfeeding (PBF), and breastfeeding (BF). The interruption of breastfeeding in the first six months was classified as early weaning. The Kaplan Meier method (log-rank: 95%) was used to estimate the conditional probability of change in breastfeeding pattern, and early weaning risk. Crude and adjusted proportional Cox regression models, and their respective 95% confidence intervals (95%CI), were used to analyze the factors associated with early weaning. RESULTS: The study included 833 infants in EBF (95.4%) and BF (4.6%) at hospital discharge. During the first six months of life, the infant likely discharged in EBF remaining in EBF, becoming PBF, and BF, were respectively 16.4%, 32.3%, and 56.5%. The weaning likely at six months was statistically higher for infants discharged in BF (47.4%) when compared with those discharged in EBF (26%). Factors associated with early weaning were BF at hospital discharge (HR = 1.82; 95%CI 1.06-3.11), no mother cross-breastfeeding (HR = 2.50; 95%CI 1.59-3.94), pacifier use (HR = 6.23; 95%CI 4.52-8.60), less than six months of breastfeeding intention (HR = 1.93; 95%CI 1.25-2.98), lack of breastfeeding in the first hour of life (HR = 1.45; 95%CI 1.10-1.92), and pregnancy alcohol consumption (HR = 1.88; 95%CI 1.34-2.90). CONCLUSION: Compared to infants in EBF, those in BF at hospital discharge were more likely to wean. Public health efforts should prioritize EBF at hospital discharge, promote breastfeeding in the first hour of life, and prevent alcohol consumption risks during pregnancy, cross-breastfeeding and pacifier use.

RESUMO OBJETIVO: Caracterizar os padrões de amamentação nos primeiros seis meses de vida e fatores associados ao desmame precoce numa coorte de nascidos vivos em Rio Branco, Acre. MÉTODOS: Estudo prospectivo com nascidos vivos entre abril e junho de 2015. As entrevistas com as mães ocorreram logo após o nascimento e entre 6 e 15 meses pós-parto. Na alta hospitalar, o aleitamento foi definido em exclusivo (AME) e materno (AM). No seguimento, os padrões de amamentação foram AME, aleitamento materno predominante (AMP) e AM. A interrupção da amamentação nos primeiros seis meses foi classificada como desmame precoce. Utilizou-se o método de Kaplan Meier (log-rank: 95%) para estimar a probabilidade condicional de mudança no padrão de amamentação e risco de desmame. Os fatores associados ao desmame e seus intervalos de confiança de 95% (IC95%) foram analisados pela regressão proporcional de Cox bruta e ajustada. RESULTADOS: Participaram do estudo 833 lactentes que na alta hospitalar estavam em AME (95,4%) e AM (4,6%). A probabilidade do lactente em AME na alta hospitalar permanecer em AME, ou se tornar AMP ou AM, aos seis meses, foi de 16,4%, 32,3% e 56,5% respectivamente. A probabilidade de desmame aos seis meses foi estaticamente maior para lactentes em AM na alta hospitalar (47,4%) em comparação com aqueles em AME (26%). Mostraram-se associados ao desmame precoce: o AM na alta hospitalar (HR = 1,82; IC95% 1,06-3,11), ausência de amamentação cruzada praticada pela mãe (HR = 2,50; IC95% 1,59-3,94), usar chupeta (HR = 6,23; IC95% 4,52-8,60), pretender amamentar por menos de seis meses (HR = 1,93; IC95% 1,25-2,98), não amamentar na primeira hora de vida (HR = 1,45; IC95% 1,10-1,92) e consumir álcool na gestação (HR = 1,88; IC95% 1,34-2,90). CONCLUSÃO: Comparados aos lactentes em AME, aqueles em AM, na alta hospitalar, apresentaram maior probabilidade de desmame. Esforços em saúde pública devem priorizar o AME na alta hospitalar, promover amamentação na primeira hora de vida e orientar sobre os riscos do consumo de álcool na gestação, amamentação cruzada e uso de chupeta.

Gene-Environment Interaction between Arg72Pro SNP and Selected Environmental Exposures among Brazilian Women Diagnosed with Benign Breast Disease.

BACKGROUND: Benign breast disease (BBD) is a factor strongly associated with breast cancer worldwide. Arg72Pro SNP association with breast cancer is controversial due to the suggestion that environmental factors are required to modulate such risk. There are no studies evaluating these environmental interactions of the aforementioned SNP within BBD. AIM: To determine the frequency of SNP Arg72Pro in a cohort of women diagnosed with BBD; and to investigate gene-environmental interactions with environmental factors. RESULTS: The genotype frequency was 44.6% for Arg/Pro, 39.3% for Arg/Arg genotype, and 16.3% for Pro/Pro homozygote. Gene-environment interaction analysis shows that when Arg/Arg is considered as reference, there is an ORinteraction with Arg/Pro and fabric exposure (OR=1.90;95%CI:1.04,3.48), solvents (OR=2.21;95%CI:1.01,4.83) and chlorine, bleaches, disinfectants, and liquid wax exposure (OR=2.52;95%CI:1.07,5.91). Analysis with Pro/Pro genotype as the reference showed an interaction between alcohol consumption and recessive model (OR=1.58;95%CI:1.00,2.51). Gene-environmental interactions were observed too between exposure to hair dyes, straighteners or relaxers and Arg/Arg (OR=3.26;95%CI:1.21,8.82). CONCLUSION: The Arg/Pro genotype was the most frequent in the BBD cohort. When compared with the Arg/Arg genotype, the presence of Arg/Pro genotype and solvents, fabric and cleaning products exposure increased the risk of BBD. When compared with Pro/Pro genotype, there were interactions between recessive model with alcohol consumption and exposure to hair products on the risk of BBD.

P53 Expression in benign Breast Disease Development: A Systematic Review.

BACKGROUND: Benign breast disease (BBD) is one of main breast cancer risk factors. Dysfunctions on p53 protein, which has a genome protective role, have been related to breast cancer developments. However, its role on BBD development is still unclear. METHODS: A systematic review of literature was proceeded according to PRISMA-P guidelines. PubMed, BVS, MEDLINE and Scholar Google were used as databases, complemented by a manual search in articles references.  Articles searches were conducted from May to July 2019 and publications in English, Spanish and Portuguese were selected. P53 expression was set as outcome among women with BBD and were included only articles with good quality according STROBE tools. Data concerning p53 expression frequencies were independently extracted by two review authors, and eligible articles were synthesized. RESULTS: From 12 studies selected for this review, the majority analyzed p53 expression in non-proliferative lesions and general p53 expressions ranged from 0 to 100%. P53 expression was more frequently observed in cases series studies (91.7%) and in studies conducted in Occidental Europe (41.7%). P53 expression was more frequent among tissues with fibrocystic disease (22.5%) and fibroadenoma (22.5%). CONCLUSION: When compared with all breast tissues types, benign breast disease corresponds to 34.39% of p53 expression. Second outcomes were not evaluated because the heterogeneity observed in selected studies. In addition, more studies considering ethnicity and benign breast disease classification should also be considered for further analysis.

[Social, demographic, and health policies history of indigenous peoples from the state of Acre, Brazil]. / Histórico social, demográfico e de saúde dos povos indígenas do estado do Acre, Brasil.

The historical trajectory experienced by Brazilian Amerindians population lead to a complex social issues, which are expressed by a lack of health service access and socioeconomic disparities. Such reality is translated into a higher level of poverty, lower education level and worse health profile, as compared to non-indigenous counterparts. The current health policies for indigenous population in Brazil could not overcome the lack of specialized care access. thus, fragmented and unplanned health care still persist, with distortions in the process of social control. Therefore, increased morbidity and mortality rates, unequal health care access, lack of continuity of care, and administrative barriers are still frequent among Brazilian Amerindians. The indigenous peoples from the State of Acre, located in the Western Brazilian Amazon, reflects the situation of greater vulnerability among all the indigenous populations from the North Region of Brazil, sharing worse health outcomes as compared to the rest of the country. Thus, the purpose of this narrative review is to characterize the history of the Indian population in Brazil and the State of Acre, according to demographic, epidemiological and health policies.

A trajetória histórica vivenciada pelos povos indígenas no Brasil coadunou numa complexa situação social que se estende com precariedade e evidentes disparidades traduzidas em pior perfil de pobreza, escolaridade e de saúde em relação a outros segmentos da sociedade nacional. As políticas de saúde direcionadas para os povos indígenas não conseguiram até a atualidade superar as lacunas do cuidado especializado, persistindo a atenção fragmentada e emergencial, manutenção de péssimo quadro de morbimortalidade, iniquidades de acesso aos serviços de saúde, elevada descontinuidade do cuidado, barreiras administrativas e distorções no processo de controle social. O Estado do Acre, localizado na Amazônia Ocidental brasileira, reflete o quadro de maior vulnerabilidade dos povos indígenas da Região Norte, que compartilham piores resultados de saúde quando comparados com o restante do país. O objetivo do presente artigo de revisão narrativa da literatura consiste em caracterizar o histórico dos povos indígenas do Acre, segundo aspectos sociodemográficos, epidemiológicos e de políticas de saúde no contexto brasileiro.

Histórico social, demográfico e de saúde dos povos indígenas do estado do Acre, Brasil / Social, demographic, and health policies history of indigenous peoples from the state of Acre, Brazil

Resumo A trajetória histórica vivenciada pelos povos indígenas no Brasil coadunou numa complexa situação social que se estende com precariedade e evidentes disparidades traduzidas em pior perfil de pobreza, escolaridade e de saúde em relação a outros segmentos da sociedade nacional. As políticas de saúde direcionadas para os povos indígenas não conseguiram até a atualidade superar as lacunas do cuidado especializado, persistindo a atenção fragmentada e emergencial, manutenção de péssimo quadro de morbimortalidade, iniquidades de acesso aos serviços de saúde, elevada descontinuidade do cuidado, barreiras administrativas e distorções no processo de controle social. O Estado do Acre, localizado na Amazônia Ocidental brasileira, reflete o quadro de maior vulnerabilidade dos povos indígenas da Região Norte, que compartilham piores resultados de saúde quando comparados com o restante do país. O objetivo do presente artigo de revisão narrativa da literatura consiste em caracterizar o histórico dos povos indígenas do Acre, segundo aspectos sociodemográficos, epidemiológicos e de políticas de saúde no contexto brasileiro.

Abstract The historical trajectory experienced by Brazilian Amerindians population lead to a complex social issues, which are expressed by a lack of health service access and socioeconomic disparities. Such reality is translated into a higher level of poverty, lower education level and worse health profile, as compared to non-indigenous counterparts. The current health policies for indigenous population in Brazil could not overcome the lack of specialized care access. thus, fragmented and unplanned health care still persist, with distortions in the process of social control. Therefore, increased morbidity and mortality rates, unequal health care access, lack of continuity of care, and administrative barriers are still frequent among Brazilian Amerindians. The indigenous peoples from the State of Acre, located in the Western Brazilian Amazon, reflects the situation of greater vulnerability among all the indigenous populations from the North Region of Brazil, sharing worse health outcomes as compared to the rest of the country. Thus, the purpose of this narrative review is to characterize the history of the Indian population in Brazil and the State of Acre, according to demographic, epidemiological and health policies.

Family history of breast cancer and risk of benign breast diseases: an integrative literature review

Introduction: Some benign breast diseases (BBD) can determine an increased risk of developing breast cancer. Environmental factors related to lifestyle and family history of breast cancer may be associated with BBD development. However, the effect of family history of breast cancer on the risk of benign breast diseases is still unclear. Objective: To evaluate the association between family history of breast cancer and benign breast diseases. Methods: This is an integrative review that selected observational studies in different databases to analyze the association between BBD and family history of breast cancer, considering the different classification criteria for both benign diseases and family history. All studies were published between 1977 and 2016. A total of 13 studies were selected, among which ten are case-control and case-cohort studies; and three are cohort studies. Most studies received high or moderate quality classification according to the Newcastle-Ottawa assessment scale. Results: Family history of breast cancer was associated with the development of proliferative lesions and the presence of atypia, and it was more closely related to the development of benign diseases in young women, with a tendency to decrease with advancing age. Conclusion: Studies suggest there may be an association between family history of breast cancer and benign breast diseases; nevertheless, no statistically significant results were found in many case-control studies, and more robust prospective research is necessary to further clarify this association.

Characterization of women with cervical cancer assisted at Inca by histological type.

OBJECTIVE: To determine the distribution of sociodemographic, reproductive, clinical and lifestyle habits in the cohort of women diagnosed with cervical cancer, assisted at Inca between 2012 and 2014, according to the histological type. METHODS: Retrospective observational study of a hospital cohort of 1,004 women diagnosed with cervical cancer. Data were obtained from the Inca hospital cancer registry, physical and electronic records. RESULTS: The most frequent histological type was squamous cell carcinoma (83.9%). Approximately 70% of the women aged more than 40 years. The study includes non-white women (67.4%), with less than 8 years of education (51.9%), with onset of sexual activity up to 16 years of age (40.7%), who were pregnant before (95.5%), with more than one pregnancy (82.9%), and more than two children (52.7%); 45.8% of the women were smokers or former smokers. Cervical adenocarcinoma was positively associated with earlier staging (IA-IIA) (OR = 1.79; 95%CI 1.03-3.13), as well as women with ≥ 12 years of education (OR = 6.30; 95%CI 1.97-20,13), who had no children (OR = 3.81; 95%CI 1.20 - 12,08) or who had up to two children (OR = 1.74; 95%CI 1.05 - 2,87). CONCLUSIONS: The difference between histological types is highlighted, suggesting that women with cervical adenocarcinoma may represent a distinct clinical entity of cervical neoplasia, which may require different approaches from those used in squamous cell carcinoma.

[Cancer mortality among indigenous population in Acre State, Brazil]. / Mortalidade por câncer em populações indígenas no Estado do Acre, Brasil.

The study aimed to estimate cancer mortality among indigenous peoples in Acre State, Brazil. This was a descriptive observational study based on the nominal bank of the Brazilian Mortality Information System for the period from January 1st, 2000, to December 31st, 2012. The study analyzed the distribution death frequencies by sex and age. Standardized mortality ratio (SMR) was calculated taking Goiânia (Goiás State), Acre State, and the North Region of Brazil as the references. A total of 81 deaths were identified, the majority in men (59.3%) and in individuals over 70 years of age. The five main sites in men were stomach, liver, colon and rectum, leukemia, and prostate. The five main sites in women were uterine cervix, stomach, liver, leukemia, and uterus. In indigenous men there was an excess of deaths from stomach cancer compared to the populations of Goiânia (SMR = 2.72; 2.58-2.87), Acre State (SMR = 2.05; 1.94-2.16) and North region (SMR = 3.10; 2.93-3.27). The same was observed for deaths from hepatic cell carcinomas referenced against Goiânia (SMR = 3.89; 3.66-4.14), Acre State (SMR = 1.79; 1.68-1.91), and the North of Brazil (SMR = 4.04; 3.77-4.30). Among indigenous women, there was an excess of cervical cancer in comparison to Goiânia (SMR = 4.67; 4.41-4.93), Acre State (SMR = 2.12; 2.00-2.24), and the North (SMR = 2.60; 2.45-2.75). The estimates show that preventable neoplasms such as cervical cancer and those linked to underdevelopment, such as stomach and liver cancer, account for 49.4% of deaths among indigenous peoples. Compared to the reference population, mortality from liver, stomach, and colorectal cancer and leukemias was more than twice as high in indigenous men; among indigenous women, cervical, stomach, and liver cancer and leukemias were 30% higher.

O objetivo do estudo foi estimar a mortalidade por câncer em povos indígenas no Estado do Acre, Brasil. Trata-se de estudo observacional descritivo, com base no banco nominal do SIM (Sistema de Informações sobre Mortalidade), referente ao período de 1º de janeiro de 2000 a 31 de dezembro de 2012. Foi analisada a distribuição de frequência de óbitos, por sexo e faixa etária, e calculada a RMP (razão de mortalidade padronizada), tendo como referência Goiânia (Goiás), Acre e Região Norte. Foram identificados 81 óbitos, a maioria de homens (59,3%) e acima de 70 anos. As cinco principais localizações em homens foram estômago, fígado, cólon e reto, leucemia e próstata. Nas mulheres, câncer cervical, estômago, fígado, leucemia e útero. Nos homens indígenas houve excesso de óbitos por câncer de estômago quando comparados às populações de Goiânia (RMP = 2,72; 2,58-2,87), Acre (RMP = 2,05; 1,94-2,16) e Região Norte (RMP = 3,10; 2,93-3,27). O mesmo foi observado para óbitos por hepatocarcinomas, tendo por referência Goiânia (RMP = 3,89; 3,66-4,14), Acre (RMP = 1,79; 1,68-1,91) e Região Norte (RMP = 4,04; 3,77-4,30). Dentre as mulheres indígenas, destaca-se o excesso de câncer cervical em relação à Goiânia (RMP = 4,67; 4,41-4,93), Acre (RMP = 2,12; 2,00-2,24) e Região Norte (RMP = 2,60; 2,45-2,75). As estimativas apontam que neoplasias passíveis de prevenção, como câncer cervical, e ligadas ao subdesenvolvimento, como estômago e fígado, corresponderam a cerca de 49,4% dos óbitos entre indígenas. Comparados à população de referência, a mortalidade por câncer de fígado, estômago, colorretal e leucemias foi maior que o dobro entre os homens indígenas; por câncer cervical, estômago, fígado e leucemias esteve acima de 30% entre as mulheres indígenas.

El objetivo del estudio fue estimar la mortalidad por cáncer en pueblos indígenas del estado de Acre. Se trata de un estudio observacional descriptivo, a partir del banco de datos nominal del SIM (Sistema de Información Sobre Mortalidad), referente al período de 01 de enero de 2000 a 31 de diciembre de 2012. Se analizó la distribución de frecuencia de óbitos, por sexo y franja de edad, y se calculó la RMP (razón de mortalidad estandarizada), teniendo como referencia Goiânia-GO, Acre y la región norte. Se identificaron 81 óbitos, la mayoría en hombres (59,3%) y por encima de los 70 años. Los cinco principales focos en hombres fueron: estómago, hígado, colon y recto, leucemia y próstata. En las mujeres, cáncer cervical, estómago, hígado, leucemia y útero. En los hombres indígenas, hubo exceso de óbitos por cáncer de estómago, comparados con las poblaciones de Goiânia (RMP = 2,72; 2,58-2,87), estado de Acre (RMP = 2,05; 1,94-2,16) y región norte (RMP = 3,10; 2,93-3,27). Lo mismo se observó en caso de óbitos por hepatocarcinomas, teniendo por referencia Goiânia (RMP = 3,89; 3,66-4,14), estado de Acre (RMP = 1,79; 1,68-1,91) y región norte (RMP = 4,04; 3,77-4,30). Entre las mujeres indígenas, se destaca el exceso de cáncer cervical, en relación con Goiânia (RMP = 4,67; 4,41-4,93), estado de Acre (RMP = 2,12; 2,00-2,24) y región norte (RMP = 2,60; 2,45-2,75). Las estimativas apuntan a que neoplasias susceptibles de prevención, como la cervical, y vinculadas al subdesarrollo, como la de estómago e hígado, correspondieron a cerca de un 49,4% de los óbitos entre indígenas. Comparados con la población de referencia, la mortalidad por cáncer de hígado, estómago, colorrectal y leucemias fue más que el doble entre los hombres indígenas; por cáncer cervical, estómago, hígado y leucemias estuvo por encima de un 30% entre las mujeres indígenas.