Effect of long COVID-19 syndrome on health-related quality of life: a cross-sectional study.

Purpose: This study aimed to assess the association of anxiety, headache, and insomnia on the QoL of patients with long COVID-19. Methods: We conducted a cross-sectional survey between August 2020 and March 2023. A total of 200 participants were eligible, 53 were excluded and 147 patients with long COVID were included. QoL was evaluated across eight domains using the 36-Item Short Form Health Survey (SF-36). Standardized protocols including the Beck Anxiety Inventory (BAI) (n = 103), Pittsburgh Sleep Quality Index (PSQI) (n = 73), and Migraine Disability Assessment (MIDAS) (n = 67) were also used. Results: Participants with sleep disorders had significantly lower Vitality (p < 0.001). Participants with anxiety disorders had significantly lower Vitality (p = 0.001), poorer Mental Health (p = 0.008), and more severe Bodily Pain (p = 0.008). Participants with headache had significantly lower Vitality (p = 0.032), poorer Mental Health (p = 0.036), and poorer Physical Functioning (p = 0.016). Participants with both headache and anxiety had significantly lower Vitality (p = 0.005) and Mental Health (p = 0.043) domain scores. Correlation analysis revealed that higher scores for anxiety, sleep disorder, and headache were independently correlated with poorer QoL across various domains. The presence of sleep disorder was associated with a fourfold increase in risk of experiencing diminished Vitality (odds ratio [OR]4.47; 95% CI 1.01-19.69; p = 0.048). Conclusion: Participants with anxiety, sleep, and headache disorders tended to have a worse QoL. The Vitality and Mental Health domains were the most adversely affected in patients with long COVID. Sleep disorders were associated with a fourfold increase in the risk of poor Vitality.

Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.

Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere (n = 150) and severe (n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19.

Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α.

The cGAS-STING pathway appears to contribute to dysregulated inflammation during coronavirus disease 2019 (COVID-19); however, inflammatory factors related to long COVID are still being investigated. In the present study, we evaluated the association of cGAS and STING gene expression levels and plasma IFN-α, TNF-α and IL-6 levels with COVID-19 severity in acute infection and long COVID, based on analysis of blood samples from 148 individuals, 87 with acute COVID-19 and 61 in the post-COVID-19 period. Quantification of gene expression was performed by real-time PCR, and cytokine levels were quantified by ELISA and flow cytometry. In acute COVID-19, cGAS, STING, IFN-α, TNF-α, and IL-6 levels were higher in patients with severe disease than in those with nonsevere manifestations (p < 0.05). Long COVID was associated with elevated cGAS, STING and IFN-α levels (p < 0.05). Activation of the cGAS-STING pathway may contribute to an intense systemic inflammatory state in severe COVID-19 and, after infection resolution, induce an autoinflammatory disease in some tissues, resulting in long COVID.

Photodynamic therapy for nodular basal cell carcinoma up to 5mm located on high-risk area: Effectiveness and long-term follow-up results.

SIGNIFICANCE: Response rates evaluation of photodynamic therapy (PDT) for nodular basal cell carcinoma (BCC) treatment located on high-risk and low-risk areas of the face. APPROACH: Two groups of nodular BCC were selected, debulked, and received 20% methyl aminolevulinate (MAL) hydrochloride cream. After 3 h, the first irradiation was performed (20 min, 150 J/cm2). Then, the cream was re-applied, and a second irradiation was performed after 1.5 h (20 min, 150 J/cm2). Clearance at 30 days and recurrence-free survival rate were evaluated. RESULTS: The clearance at 30 days after PDT was 89% for the low-risk area group and 87% for the high-risk group. The recurrence-free survival at 60 months was 82% and 85% for the high-risk and low-risk groups, respectively. CONCLUSIONS: No significant differences were observed between groups nor for clearance at 30 days, nor recurrence-free follow-up. These results make PDT possible option for nodular BCC less than 5 mm located in high-risk areas.

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population.

Interleukin-6 has been recognized as a major role player in COVID-19 severity, being an important regulator of the cytokine storm. Hence, the evaluation of the influence of polymorphisms in key genes of the IL-6 pathway, namely IL6, IL6R, and IL6ST, may provide valuable prognostic/predictive markers for COVID-19. The present cross-sectional study genotyped three SNPs (rs1800795, rs2228145, and rs7730934) at IL6. IL6R and IL6ST genes, respectively, in 227 COVID-19 patients (132 hospitalized and 95 non-hospitalized). Genotype frequencies were compared between these groups. As a control group, published data on gene and genotype frequencies were gathered from published studies before the pandemic started. Our major results point to an association of the IL6 C allele with COVID-19 severity. Moreover, IL-6 plasmatic levels were higher among IL6 CC genotype carriers. Additionally, the frequency of symptoms was higher at IL6 CC and IL6R CC genotypes. In conclusion, the data suggest an important role of IL6 C allele and IL6R CC genotype on COVID-19 severity, in agreement with indirect evidence from the literature about the association of these genotypes with mortality rates, pneumonia, and heightening of protein plasmatic levels pro-inflammatory driven effects.

Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19.

Introduction: Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, and may influence the synthesis of inflammatory cytokines. This study investigated the association of MBL2 gene polymorphisms with the plasma levels of MBL and inflammatory cytokines in COVID-19. Methods: Blood samples from 385 individuals (208 with acute COVID-19 and 117 post-COVID-19) were subjected to real-time PCR genotyping. Plasma measurements of MBL and cytokines were performed by enzyme-linked immunosorbent assay and flow cytometry, respectively. Results: The frequencies of the polymorphic MBL2 genotype (OO) and allele (O) were higher in patients with severe COVID-19 (p< 0.05). The polymorphic genotypes (AO and OO) were associated with lower MBL levels (p< 0.05). IL-6 and TNF-α were higher in patients with low MBL and severe COVID-19 (p< 0.05). No association of polymorphisms, MBL levels, or cytokine levels with long COVID was observed. Discussion: The results suggest that, besides MBL2 polymorphisms promoting a reduction in MBL levels and therefore in its function, they may also contribute to the development of a more intense inflammatory process responsible for the severity of COVID-19.

Thrombophilia and Immune-Related Genetic Markers in Long COVID.

Aiming to evaluate the role of ten functional polymorphisms in long COVID, involved in major inflammatory, immune response and thrombophilia pathways, a cross-sectional sample composed of 199 long COVID (LC) patients and a cohort composed of 79 COVID-19 patients whose follow-up by over six months did not reveal any evidence of long COVID (NLC) were investigated to detect genetic susceptibility to long COVID. Ten functional polymorphisms located in thrombophilia-related and immune response genes were genotyped by real time PCR. In terms of clinical outcomes, LC patients presented higher prevalence of heart disease as preexistent comorbidity. In general, the proportions of symptoms in acute phase of the disease were higher among LC patients. The genotype AA of the interferon gamma (IFNG) gene was observed in higher frequency among LC patients (60%; p = 0.033). Moreover, the genotype CC of the methylenetetrahydrofolate reductase (MTHFR) gene was also more frequent among LC patients (49%; p = 0.045). Additionally, the frequencies of LC symptoms were higher among carriers of IFNG genotypes AA than among non-AA genotypes (Z = 5.08; p < 0.0001). Two polymorphisms were associated with LC in both inflammatory and thrombophilia pathways, thus reinforcing their role in LC. The higher frequencies of acute phase symptoms among LC and higher frequency of underlying comorbidities might suggest that acute disease severity and the triggering of preexisting condition may play a role in LC development.

Antibody Response to the SARS-CoV-2 Spike and Nucleocapsid Proteins in Patients with Different COVID-19 Clinical Profiles.

The first case of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in Brazil was diagnosed on February 26, 2020. Due to the important epidemiological impact of COVID-19, the present study aimed to analyze the specificity of IgG antibody responses to the S1, S2 and N proteins of SARS-CoV-2 in different COVID-19 clinical profiles. This study enrolled 136 individuals who were diagnosed with or without COVID-19 based on clinical findings and laboratory results and classified as asymptomatic or as having mild, moderate or severe disease. Data collection was performed through a semistructured questionnaire to obtain demographic information and main clinical manifestations. IgG antibody responses to the S1 and S2 subunits of the spike (S) protein and the nucleocapsid (N) protein were evaluated using an enzyme-linked immunosorbent assay (ELISA) according to the manufacturer's instructions. The results showed that among the participants, 87.5% (119/136) exhibited IgG responses to the S1 subunit and 88.25% (120/136) to N. Conversely, only 14.44% of the subjects (21/136) displayed S2 subunit responses. When analyzing the IgG antibody response while considering the different proteins of the virus, patients with severe disease had significantly higher antibody responses to N and S1 than asymptomatic individuals (p ≤ 0.0001), whereas most of the participants had low antibody titers against the S2 subunit. In addition, individuals with long COVID-19 showed a greater IgG response profile than those with symptomatology of a short duration. Based on the results of this study, it is concluded that levels of IgG antibodies may be related to the clinical evolution of COVID-19, with high levels of IgG antibodies against S1 and N in severe cases and in individuals with long COVID-19.

Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome.

The duration and severity of COVID-19 are related to age, comorbidities, and cytokine synthesis. This study evaluated the impact of these factors on patients with clinical presentations of COVID-19 in a Brazilian cohort. A total of 317 patients diagnosed with COVID-19 were included; cases were distributed according to clinical status as severe (n=91), moderate (n=56) and mild (n=170). Of these patients, 92 had acute COVID-19 at sample collection, 90 had already recovered from COVID-19 without sequelae, and 135 had sequelae (long COVID syndrome). In the acute COVID-19 group, patients with the severe form had higher IL-6 levels (p=0.0260). In the post-COVID-19 group, there was no significant difference in cytokine levels between groups with different clinical conditions. In the acute COVID-19 group, younger patients had higher levels of TNF-α, and patients without comorbidities had higher levels of TNF-α, IL-4 and IL-2 (p<0.05). In contrast, patients over age 60 with comorbidities had higher levels of IL-6. In the post-COVID-19 group, subjects with long COVID-19 had higher levels of IL-17 and IL-2 (p<0.05), and subjects without sequelae had higher levels of IL-10, IL-6 and IL- 4 (p<0.05). Our results suggest that advanced age, comorbidities and elevated serum IL-6 levels are associated with severe COVID-19 and are good markers to differentiate severe from mild cases. Furthermore, high serum levels of IL-17 and IL-2 and low levels of IL-4 and IL-10 appear to constitute a cytokine profile of long COVID-19, and these markers are potential targets for COVID-19 treatment and prevention strategies.

Atenção, regulação e vigilância / Attention, regulation and surveillance

Relato de experiências das unidades da Secretaria de Estado da Saúde de Goiás, no período de 2019 a 2022. Relata sobre a regionalização dos serviços de saúde, processo que possibilita a definição de recortes espaciais para fins de planejamento, organização e gestão de redes de ações e serviços de saúde. Discorre sobre o financiamento da Atenção Primária em Saúde, a estruturação da Rede Estadual de Policlínicas, o planejamento da alta hospitalar responsável ou desospitalização, os avanços e equipes especializadas em saúde mental

Report on the experiences of the units of the State Department of Health of Goiás, from 2019 to 2022. It reports on the regionalization of health services, a process that allows the definition of spatial cuts for planning, organization and management of action networks and health services. Discusses the financing of Primary Health Care, the structuring of the State Network of Polyclinics, the planning of responsible hospital discharge or dehospitalization, advances and specialized teams in mental health

Mobile application for the evaluation and planning of nursing workload in the intensive care unit.

OBJECTIVE: In this study, we present an application type software which employs the Nursing Activities Score (NAS), a management tool for measuring nursing workload prospectively. METHOD: The system was developed in two modules: WEB (controlled from an Internet browser) for data administration using Java Script; and APP (operated from a smartphone or tablet device) for data acquisition using Hypertext Preprocessor (PHP). White and black box tests were performed in the software. RESULTS: A software was developed with an interface that allows the calculation of the scale score by the same professional who provided assistance, generating reports to help nursing management. The functional test was successfully performed using the Android operational system. CONCLUSION: The efficiency of the software was demonstrated by the functional test and the main innovations brought herein are the prospective use and the generation of management reports, which can contribute positively by improving nursing quality and safety in the intensive care unit.

Integrating environmental variables by multivariate ordination enables the reliable estimation of mineland rehabilitation status.

Despite the wide variety of variables commonly employed to measure the success of rehabilitation, the assessment and subsequent definition of indicators of environmental rehabilitation status are not simple tasks. The main challenges are comparing rehabilitated sites with target ecosystems as well as integrating individual environmental and eventually collinear variables into a single tractable measure for the state of a system before effective indicators that track rehabilitation may be modeled. Furthermore, a consensus is lacking regarding which and how many variables need to be surveyed for a reliable estimation of rehabilitation status. Here, we propose a multivariate ordination to integrate variables related to ecological processes, vegetation structure, and community diversity into a single estimation of rehabilitation status. As a case, we employed a curated set of 32 environmental variables retrieved from nonrevegetated, rehabilitating and reference sites associated with iron ore mines from the Urucum Massif, Mato Grosso do Sul, Brazil. By integrating this set of environmental variables into a single estimation of rehabilitation status, the proposed multivariate approach is straightforward and able to adequately address collinearity among variables. The proposed methodology allows for the identification of biases towards single variables, surveys or analyses, which is necessary to rank environmental variables regarding their importance to the assessment. Furthermore, we show that bootstrapping permitted the detection of the minimum number of environmental variables necessary to achieve reliable estimations of the rehabilitation status. Finally, we show that the proposed variable integration enables the definition of case-specific environmental indicators for more rapid assessments of mineland rehabilitation. Thus, the proposed multivariate ordination represents a powerful tool to facilitate the diagnosis of rehabilitating sites worldwide provided that sufficient environmental variables related to ecological processes, diversity and vegetation structure are gathered from nonrehabilitated, rehabilitating and reference study sites. By identifying deviations from predicted rehabilitation trajectories and providing assessments for environmental agencies, this proposed multivariate ordination increases the effectiveness of (mineland) rehabilitation.

Perfil epidemiológico de pacientes com câncer de pulmão em um hospital público de referência oncológica do estado do Pará. / Epidemiologic profile of patients with lung cancer in public hospital of oncologic reference of state of Pará

Objetivo: traçar o perfil epidemiológico dos pacientes com diagnóstico de câncer de pulmão tratados no Hospital Ophir Loyola, na cidade de Belém-Pará. Método: estudo do tipo transversal, exploratório e descritivo, com coleta de dados em prontuários, tendo como critérios de inclusão o diagnóstico de câncer de pulmão, pacientes de ambos os sexos, sem limite de idade, atendidos de janeiro de 2010 a dezembro de 2011 e critérios de exclusão os pacientes não residentes ou não procedentes do Estado do Pará e prontuários com dados incompletos. A coleta de dados foi desenvolvida através de ficha de protocolo pré-elaborada pelos pesquisadores. A pesquisa foi realizada na Divisão de Arquivo Médico e Estatístico (DAME) do Hospital Ophir Loyola, sendo os dados analisados através de estatística descritiva. Resultados: observou-se que a maioria dos pacientes era do sexo masculino (72, 22%), sendo a maior procedência do interior do Estado (58%). A faixa etária de maior frequência de câncer de pulmão foi entre 61 a 70 anos de idade (35,56%). O subtipo histológico de maior frequência foi o carcinoma escamoso (37,22%), seguido do adenocarcinoma (31,67%). Da amostra total 94,44% dos carcinomas pulmonares eram do tipo primário. Em relação a sobrevida e mortalidade no período da pesquisa houve sobrevida de 52,78% e mortalidade de 47,22%. Conclusão: os dados obtidos permitiram caracterizar o perfil epidemiológico do câncer de pulmão na região estudada, servindo como base de dados para estudos epidemiológicos futuros e como subsídio para a implementação de políticas públicas preventivas na região norte do país.

Revista Paraense de Medicina - V.28 (1) janeiro-março 2014 60Objective: trace the epidemiological profile of the patients with lung cancer diagnosis treated in the hospital Ophir Loyola, in the city of Belém-Pará. Methods: performs cross-sectional, exploratory and descriptive study, through data gathering of medical records of 180 patients, having as inclusion criterion the lung cancer diagnosis, patients of both genders, without age limit, treated during the period of January of 2010 to December of 2011 and as exclusion criterion the patients that don?t live or aren?t from the Pará State and incomplete medical records data, with more than two missing variables. The data gathering was developed through protocol record pre-prepared by the researchers. The Research was realized in the Division of statistical and Medical files (DSMF) of the Hospital Ophir Loyola, with data being analyzed by descriptive statistics. Results: was observed that most part of the patients were males (72,22%), being the highest origin from the State interior (58%). The age group with the highest lung cancer incidence was around 61 to 70 years old (35,56%). The histological subtype with the highest incidence was the squamous cell carcinoma (37,22%), followed by the adenocarcinoma (31,67%). Of the total sample 94,44% of the lung carcinomas belonged to the primary type. Relative to the survival and mortality during the period of the research there was survival of 52,78% and mortality of 47,22%. Conclusion: the obtained data allowed to characterize the epidemiological profile of lung cancer in the studied region, serving as data base for future epidemiological studies and as subsidy for the implementation of preventive public politics in the northern region of the Country.

Leguminosae no Pantanal de Barão de Melgaço, Mato Grosso, Brasil / Leguminosae in the Pantanal of Barão de Melgaço, Mato Grosso, Brazil

O Pantanal brasileiro é constituído por onze sub-regiões, sendo uma delas a do Pantanal de Barão de Melgaço, localizado ao nordeste da bacia sedimentar quaternária. Considerando que Leguminosae é apontada como uma das famílias mais abundantes na região do Pantanal, este trabalho teve por objetivo apresentar uma lista dos táxons de Leguminosae ocorrentes no Pantanal de Barão de Melgaço, município de Barão de Melgaço, estado do Mato Grosso. Para as espécies são fornecidas informações sobre o hábito e tipo de vegetação. Um total de 40 táxons foi registrado, pertencendo a 23 gêneros. A maioria das espécies são árvores e ocorrem essencialmente nas formações ciliares. Este estudo aponta, dentre as espécies encontradas, dois novos registros para o estado do Mato Grosso, que são: Aeschynomene evenia C. Wright ex Sauvalle e Pterocarpus villosus (Benth.) Benth.

The Brazilian Pantanal is composed of eleven sub-regions, one of them the Pantanal of Barão de Melgaço, located northeast of the Quaternary sedimentary basin. Considering that Leguminosae is identified as one of most abundant families in the Pantanal region, this study aimed to present a list of taxa of Leguminosae taxa occurring in the Pantanal of Barão de Melgaço, municipality of Barão de Melgaço, Mato Grosso state. Information about the habit and vegetation type are provided for all the species. A total of 40 táxons were recorded and its belong to 23 genera. Most species are tree and occur primarily in riparian vegetation. This study shows, among the species reported, two new records for the Mato Grosso state, that are: Aeschynomene evenia C. Wright ex Sauvalle and Pterocarpus villosus (Benth.) Benth.

Leguminosae do município de Poconé, Pantanal de Poconé, Mato Grosso, Brasil / Leguminosae at Poconé, Pantanal of Poconé, Mato Grosso, Brazil

Este trabalho apresenta o levantamento florístico de Leguminosae do município de Poconé, localizado no Pantanal de Poconé, Mato Grosso, Brasil, entre as coordenadas 16° 00´-17° 38´ S e 55° 59´ 46"-57º 38´ 38" W. Coletas assistemáticas de espécimes de Leguminosae foram feitas entre 2007 e 2009 e o material tombado no Herbário UFMT. Na área de estudo, Leguminosae está representada por 54 gêneros e 99 espécies e duas variedades, sendo 12 gêneros e 29 espécies e duas variedades pertencentes à subfamília Caesalpinioideae, 12 gêneros e 19 espécies pertencentes à subfamília Mimosoideae, e 30 gêneros e 51 espécies à Papilionoideae. Senna foi o gênero mais expressivo (7 ssp.), seguido por Bauhinia e Desmodium (5), Chamaecrista, Inga e Mimosa (4), Copaifera, Crotalaria, Discolobium, Indigofera e Stylosanthes (3), Aeschynomene, Albizia, Andira, Eriosema, Galactia, Hymenaea, Machaerium, Phanera, Pterodon, Sesbania, Vigna e Zornia (2), e os demais gêneros com uma espécie cada. Houve um acréscimo de 30 espécies não citadas previamente para a região do Pantanal. Dentre as espécies registradas podemos salientar o primeiro registro para o município e estado de Chamaecrista mucronata (Spreng.) H.S. Irwin & Barneby.

This paper presents a floristic survey of Leguminosae at Poconé township, situated in Pantanal of Poconé, Mato Grosso State, Brazil, among 16° 00´-17° 38´ S and 55° 59´ 46"-57º 38´ 38" W. Unsystematic collects of specimens of Leguminosae were done between 2007 and 2009 and the material was deposited in the UFMT Herbarium. In the study area, Leguminosae is represented by 54 genera and 99 species and two varieties, of which 12 genera and 29 species and two varieties belongs to the subfamily Caesalpinioideae, 12 genera and 19 species to subfamily Mimosoideae, and 30 genera and 51 species to subfamily Papilionoideae. Senna was the most expressive genus (7 spp.), followed by Bauhinia and Desmodium (5), Chamaecrista, Inga and Mimosa (4), Copaifera, Crotalaria, Discolobium, Indigofera and Stylosanthes (3), Aeschynomene, Albizia, Andira, Eriosema, Galactia, Hymenaea, Machaerium, Phanera, Pterodon, Sesbania, Vigna and Zornia (2), while the other ones presents only one species each. An increase of 30 species not cited to Pantanal region. Amongst the species that have been registered we can emphasize Chamaecrista mucronata (Spreng.) H.S. Irwin & Barneby as a first record to Poconé and Mato Grosso State.

Diagnósticos de enfermagem identificados em pacientes no período pré­ operatório de cirurgias cardíacas / Nursing diagnoses identified in pre-surgical of cardiac surgery patients

Objetivos: descrever os títulos dos Diagnósticos de Enfermagem (DE) identificados em pacientes no período préoperatório de cirurgia cardíaca, categorizá-los de acordo com os domínios da NANDA e classificá-los de acordo com as Necessidades Humanas Básicas (NHB). Metodologia: trata-se de uma pesquisa bibliográfica realizada na biblioteca virtual em saúde. Para a busca, foram utilizados os limites: trabalhos publicados no período de 2001 a 2009, faixa etária adulto, meia idade, idoso e idoso acima de 80 anos, na espécie humana, nos idiomas português, inglês e espanhol. Foram realizadas seis estratégias de busca. Resultados: foram identificados 34 títulos diagnósticos nas publicações. Estes foram categorizados em doze domínios da NANDA e classificados de acordo com as NHB, havendo um predomínio nas necessidades psicobiológicas (77%), seguida das psicossociais (20%) e psicoespirituais (3%). Conclusão: foram identificados 34 títulos de diagnósticos de enfermagem em pacientes no pré-operatório de cirurgia cardíaca. Houve predomínio de problemas relacionados com a esfera biológica, o que sugere uma maior preocupação destes profissionais com os aspectos fisiológicos em decorrência da gravidade da doença e do procedimento cirúrgico.(AU)

A atenção em saúde bucal para DST/HIV/AIDS na rede municipal de Belo Horizonte: diagnóstico loco-regional

Estudo sobre a situação e qualidade do atendimento odontológico aos portadores de DST/HIV/AIDS, no SUS da rede Municipal de Belo Horizonte.

Avaliação físico-química de méis de Apis mellifera L., 1758 (Hymenoptera, Apidae) produzidos na Paraíba, Brasil / Physico-chemical evaluation of honeys of Apis mellifera L. 1758 (Hymenoptera, Apidae) produced in Paraíba, Brazil

Assim como os demais estados do Nordeste, a Paraíba também apresenta potencial apícola devido as suas condições de vegetação e ambientais favoráveis. (...) Este trabalho contribui para a identificação das diferenças e semelhanças entre os locais e época de produção do mel no período de dezembro de 2004 a novembro de 2005. Realizou-se análise de umidade, cinzas, ºBrix, sacarose, açúcares redutores, acidez (meq/kg) e pH, submetendo-se os resultados à análise de componentes principais. Os valores médios de umidade (18,75 por cento), ºBrix (80,11), açúcares redutores (79,63 por cento), sacarose (5,92 por cento), cinzas (1,52 por cento), acidez (33,92 meq/kg), pH (3,94) apresentam-se dentro do estabelecido pela legislação vigente.

Características físico-químicas e atividade antimicrobiana de extratos de própolis da Paraíba, Brasil / Physicochemical characteristics and antimicrobial activity of the extracts propolis of the Paraiba, Brazil

Objetivou-se com esta pesquisa analisar a própolis produzida por abelhas Apis mellifera L. no Estado da Paraíba, colhida pelo método de tela plástica, determinando-se a composição físico-química e a atividade antimicrobiana conforme o período de colheita das amostras. Para a determinação físico-química, foram avaliados os teores de umidade, cinzas, resíduos insolúveis, cera, sólidos solúveis, fenóis, flavonóides e índice de oxidação. Para o estudo da atividade antimicrobiana, foram utilizados os microrganismos Candida albicans e Staphylococcus aureus. O teor de umidade, os resíduos insolúveis, as cinzas, os sólidos solúveis, os fenóis, os flavonóides e o índice de oxidação das amostras testadas apresentaram uma variação de 1,0 a 8,6 por cento; 23,5 a 40,4 por cento; 1,1 a 3,3 por cento; 32,0 a 62,5 por cento; 1,0 a 8,1 por cento; 0,04-0,5 por cento e de 14 a 29 segundos, respectivamente. Os extratos etanólicos de própolis não apresentaram inibição ao crescimento dos patógenos testados. Observou-se, também, que a própolis colhida em diferentes épocas do ano, assim como a própolis oriunda de diferentes colméias, apresentaram diferentes valores para a composição bromatológica e bioativa, tendo a própolis amostrada nos períodos de maior precipitação os melhores valores para compostos bioativos.

This study was aimed at analysing the propolis produced in beehive of Apis mellifera L. bee in the state of Paraiba - Brazil. Propolis was collected by the method of plastic screen, determining the physical-chemical composition and antimicrobial activity according to the period of collection of the samples. For the physical-chemical determination, it was assessed the humidity, ashes, insoluble residues, wax, soluble solids, phenols, flavonoids and oxidation index. To study the antimicrobial activity, microorganisms Candida albicans and Staphylococcus aureus were used. The humidity contents, insoluble residues, ashes, soluble solids, phenols, flavonids and index of oxidation of the tested propolis varied from 1.03 to 8.58 percent; 23.47 to 40.38 percent; 1.13 to 3.25 percent; 31.97 to 62.54 percent; 1.01 to 8.13 percent; 0.045-0.52 percent and from 14 to 29 seconds, respectively. None of the etanol extracts of propolis inhibited the growth of bacteria pathogenic. It was also observed that the propolis collected in different times of the year, as well as propolis originated from of different beehives, showed different chemical composition and bioactive and that propolis sampled in periods of greater precipitation had better values of bioactive compounds.

Educação permanente em saúde no desenvolvimento organizacional do serviço de enfermagem da Fundação Santa Casa de Misericórdia do Pará / Permanent education in health in development organizacional of the service of nursing of the Fundação Santa Casa de Misericórdia do Pará

Objetivo: contribuir para formação de profissionais da área de enfermagem no que se refere ao conhecimento e realização de procedimentos técnicos e ao desenvolvimento interpessoal para promover atendimento de qualidade e humanizado. Método: estudo analítico do planejamento organizacional anual dos cursos dirigidos às gerências de enfermagem. Avaliaram-se as reações pelos profissionais participantes, quanto à clareza e objetividade na exposição, ao material de apoio, à comunicação com os participantes e o despertar de interesse dos mesmos e, também, a média de participantes nos cursos. Resultados e conclusões: nas avaliações das reações pelos profissionais do processo, 63,8% dos participantes acharam excelente a clareza e objetividade da exposição; 59% definiram como bom o material de apoio usado nos cursos; 61,5% consideraram excelente a comunicação dos participantes e os assuntos abordados despertaram os interesses de 97,9% com pontuação excelente. Na avaliação quantitativa verificou-se que, durante o período de fevereiro a novembro de 2005, o total de participações foi de 1083 em 28 cursos realizados, em média de 39 participantes por curso.

Objective: to contribute for formation of professionals of the area of nursing as for the knowledge am accomplishment of procedures technician and to the interpersonal development, to promote quality attendancj and humanized. Method: analytical study of the annual organizational planning of the courses directed to the managements of nursing. Results: the evaluations of reactions carried through for the participant professionals had been evaluated. How much to the clarity and objetividad in the exposition, how much to the material of support how much to the communication with the participants and the wakening of interest of the participants. Analyzer, also, the average of participants in the courses. Conclusions: in the evaluations of reactions carried through for the professionals of the process, 63,8% of the participants had found the clarity excellent and objetividad of the exposition, 59% had defined as good the material of used support in the courses, 0,15% had considered excellent the communication of the participants and the boarded subjects despertaram the interests of 97,9% with excellent punctuation. In the quantitative evaluation it was verified that, during the period of February the November of 2005, the participation total was of 1083 in 28 carried through courses, in average of 39 participants fo course.