Caesarean section and risk of type 1 diabetes.

AIMS/HYPOTHESIS: Delivery by Caesarean section continues to rise globally and has been associated with the risk of developing type 1 diabetes and the rate of progression from pre-symptomatic stage 1 or 2 type 1 diabetes to symptomatic stage 3 disease. The aim of this study was to examine the association between Caesarean delivery and progression to stage 3 type 1 diabetes in children with pre-symptomatic early-stage type 1 diabetes. METHODS: Caesarean section was examined in 8135 children from the TEDDY study who had an increased genetic risk for type 1 diabetes and were followed from birth for the development of islet autoantibodies and type 1 diabetes. RESULTS: The likelihood of delivery by Caesarean section was higher in children born to mothers with type 1 diabetes (adjusted OR 4.61, 95% CI 3.60, 5.90, p<0.0001), in non-singleton births (adjusted OR 4.35, 95% CI 3.21, 5.88, p<0.0001), in premature births (adjusted OR 1.91, 95% CI 1.53, 2.39, p<0.0001), in children born in the USA (adjusted OR 2.71, 95% CI 2.43, 3.02, p<0.0001) and in children born to older mothers (age group >28-33 years: adjusted OR 1.19, 95% CI 1.04, 1.35, p=0.01; age group >33 years: adjusted OR 1.80, 95% CI 1.58, 2.06, p<0.0001). Caesarean section was not associated with an increased risk of developing pre-symptomatic early-stage type 1 diabetes (risk by age 10 years 5.7% [95% CI 4.6%, 6.7%] for Caesarean delivery vs 6.6% [95% CI 6.0%, 7.3%] for vaginal delivery, p=0.07). Delivery by Caesarean section was associated with a modestly increased rate of progression to stage 3 type 1 diabetes in children who had developed multiple islet autoantibody-positive pre-symptomatic early-stage type 1 diabetes (adjusted HR 1.36, 95% CI 1.03, 1.79, p=0.02). No interaction was observed between Caesarean section and non-HLA SNPs conferring susceptibility for type 1 diabetes. CONCLUSIONS/INTERPRETATION: Caesarean section increased the rate of progression to stage 3 type 1 diabetes in children with pre-symptomatic early-stage type 1 diabetes. DATA AVAILABILITY: Data from the TEDDY study ( https://doi.org/10.58020/y3jk-x087 ) reported here will be made available for request at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repository (NIDDK-CR) Resources for Research (R4R) ( https://repository.niddk.nih.gov/ ).

Two roads leading to the same evaluative conditioning effect? Stimulus-response binding versus operant conditioning.

Evaluative Conditioning (EC) refers to changes in our liking or disliking of a stimulus due to its pairing with other positive or negative stimuli. In addition to stimulus-based mechanisms, recent research has shown that action-based mechanisms can also lead to EC effects. Research, based on action control theories, has shown that pairing a positive or negative action with a neutral stimulus results in EC effects (Stimulus-Response binding). Similarly, research studies using Operant Conditioning (OC) approaches have also observed EC effects. The aim of the present study is to directly compare EC effects elicited by two different response-based approaches - S-R bindings and OC. To this end, participants were randomly assigned to an S-R binding procedure and an OC procedure. EC effects were measured in conditions and compared. Implications for EC theory are discussed.

The Functional Self.

Current research describes a particular component of the self-concept that influences a wide variety of cognitive processes while it depicts a rather basic component of the self-concept. However, this minimal self seems to be anything but simple; in fact, it seems to be highly functional. Based on previous findings on newly formed self-associations, we put the postulated functionality of this minimal self to another test by retesting its protection mechanisms against negative content. In a pilot experiment, we did not find an overall reduction of negative self-assignments against neutral self-assignments. However, the results indicated an initial difference (as hypothesized) between negative and neutral self-assignments, which decreases over the course of the experiment. We put this interactive effect of valence and block to test in our main experiment, which replicated the data pattern of the pilot experiment. In sum, the results indicate a mandatory integration of stimuli into the self-concept and also a reduction of the integration due to negative valence, thereby supporting a robust protection mechanism.

The Influence of Cognitive Load on Distractor-Response Bindings.

Binding theories postulate an integration of stimulus and response features into temporary episodic traces or event files. In general, in the visual binding literature, attention is considered to be necessary to feature binding, and a higher cognitive load can lead to worse performance. On the other hand, in stimulus-response binding theories, central attention is not regarded as necessary in binding effects. A possible discrepancy between the visual feature binding findings and the findings in stimulus-response binding studies could lie in the amount of central load implemented, whereas another discrepancy was related to a specific type of process that was manipulated. In the present study, load was manipulated in three levels, such as no load, low load, and high load, and the binding effects were tested under each condition. Load was manipulated by using a secondary task, which was to be carried out simultaneously with the primary task. Additionally, the influence of targeting different working memory processes (maintenance and updating) was examined by varying the time point of the presentation of the secondary task. The results indicate that, under high load, binding effects are observed if memory contents are merely maintained, but not observed when memory contents are actively updated.

The influence of stress on distractor-response bindings.

Stimuli and responses that occur in close temporal contiguity are bound to each other and stored in short-term episodic traces or event files. A repetition of any of the features within an event file results in the retrieval of the entire event file and can influence responding. Along with task-relevant features, event files also contain task-irrelevant features, which are also bound to responses - distractor-response binding. In the present study, the distractor-response binding effect was examined under stress. Stress was induced via a Cold Pressor Test (CPT) and was manipulated between subjects. Distractor-response binding effects were measures at pre- and post-intervention. The CPT produced reliable effects on cortisol measurements and subjective ratings, however, no difference in the distractor-response binding effects between the groups was observed. Results are discussed against the background of the inconsistent results in the literature with respect to stimulus-response binding and stress.

Perturbation of the right prefrontal cortex disrupts interference control.

Resolving cognitive interference is central for successful everyday cognition and behavior. The Stroop task is a classical measure of cognitive interference. In this task, participants have to resolve interference on a trial-by-trial basis and performance is also influenced by the trial history, as reflected in sequence effects. Previous neuroimaging studies have associated the left and right prefrontal cortex with successful performance in the Stroop task. Yet, the causal relevance of both regions for interference processing remains largely unclear. We probed the functional relevance of the left and right prefrontal cortex for interference control. In three sessions, 25 healthy participants received online repetitive transcranial magnetic stimulation (rTMS) over the left and right dorsolateral prefrontal cortex, and sham stimulation over the vertex. During each session, participants completed a verbal-response Stroop task. Relative to sham rTMS and rTMS over the left prefrontal cortex, rTMS over the right prefrontal cortex selectively disrupted the Stroop sequence effect (i.e., the congruency sequence effect; CSE). This effect was specific to sequential modulations of interference since rTMS did not affect the Stroop performance in the ongoing trial. Our results demonstrate the functional relevance of the right dorsolateral prefrontal cortex for the processing of interference control. This finding points towards process-specific lateralization within the prefrontal cortex. The observed process- and site-specific TMS effect provides new insights into the neurophysiological underpinnings of Stroop task performance and more general, the role of the prefrontal cortex in the processing of interference control.

The official soundtrack to "Five shades of grey": Generalization in multimodal distractor-based retrieval.

When responding to two events in a sequence, the repetition or change of stimuli and the accompanying response can benefit or interfere with response execution: Full repetition leads to benefits in performance while partial repetition leads to costs. Additionally, even distractor stimuli can be integrated with a response, and can, upon repetition, lead to benefits or interference. Recently it has been suggested that not only identical, but also perceptually similar distractors retrieve a previous response (Singh et al., Attention, Perception, & Psychophysics, 78(8), 2307-2312, 2016): Participants discriminated four visual shapes appearing in five different shades of grey, the latter being irrelevant for task execution. Exact distractor repetitions yielded the strongest distractor-based retrieval effect, which decreased with increasing dissimilarity between shades of grey. In the current study, we expand these findings by conceptually replicating Singh et al. (2016) using multimodal stimuli. In Experiment 1 (N=31), participants discriminated four visual targets accompanied by five auditory distractors. In Experiment 2 (N=32), participants discriminated four auditory targets accompanied by five visual distractors. We replicated the generalization of distractor-based retrieval - that is, the distractor-based retrieval effect decreased with increasing distractor-dissimilarity. These results not only show that generalization in distractor-based retrieval occurs in multimodal feature processing, but also that these processes can occur for distractors perceived in a different modality to that of the target.

The role of location in the organization of bindings within short-term episodic traces.

Binding theories postulate short-term episodic traces within which stimulus and response features are integrated. These episodic traces can influence actions by facilitating or interfering with responding. Although the existence of such short-term episodic traces has been well documented, the role of location and the organization of bindings within the episodic traces is still not quite clear. While some theories suggest a key role for location, others do not. Similarly, some theories and empirical findings suggest the existence of object representations within episodic traces, while other theories suggest that bindings are purely binary, that is, consisting of only two features, and that no hierarchical bindings or object representations exist. The aim of the present study was to take a closer look at how bindings are organized within episodic traces: more specifically, the role of location in the organization of bindings was examined. Bindings were tested under two conditions; with varying spatial location of the stimuli (Experiment 1), and with a constant location of the stimuli (Experiment 2). The results suggest that when location varies, bindings are organized in an object-filelike structure within episodic traces, and when location is constant, bindings are binary in nature. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

David and Goliath-size does matter: size modulates feature-response binding of irrelevant features.

Stimulus and response features are integrated together in episodic traces. A repetition of any of the features results in the retrieval of the entire episodic trace, including the response features. Such S-R bindings have been suggested to account for different priming effects like repetition priming, negative priming and so on. Previous studies on repetition priming have found priming effects to be size invariant. The present study examines whether the size invariance in previous priming studies was due to the absence of size-response binding. In two experiments, size was varied orthogonally to the response, either without varying any other stimulus features (Experiment 1) or while varying another stimulus feature (Experiment 2). A significant size-response binding effect was observed in Experiment 1 but not in Experiment 2. The results suggest that size is involved in feature-response binding and can retrieve the response upon repetition. However, this retrieval is extinguished if another stimulus feature is varied simultaneously. The results are discussed against the background of S-R binding as the mechanism underlying repetition priming.

Binding abstract concepts.

Binding theories assume that a stimulus and the response made to it are bound together in an event file (Hommel et al., Behav Brain Sci 24(05):849-937, 2001). Such bindings can occur even after single encounters. If the stimulus or parts of its features are repeated within the time frame in which the event file is still intact, the previously integrated response is retrieved. Stimulus-response binding can exist at a perceptual, conceptual or a response selection level (Henson et al., Trends Cogn Sci 18(7):376-384, 2014). The current experiments test whether the observed binding of concepts with responses can be extended from concrete to abstract concepts (detailedness) and whether abstract concepts can retrieve the previous response, in the absence of perceptual repetition. In the present experiment participants responded to a target feature (colour) while the detailedness of the stimulus was irrelevant to the task. The results showed a significant interaction of response relation and detailedness relation, even in the absence of perceptual repetition. This interaction is interpreted as evidence for response-retrieval due to abstract concept repetition. Thus, our data suggest a broader impact of binding mechanism on performance as even abstract concepts can be integrated into event-files and later modulate behaviour.

May I have your attention please: Binding of attended but response-irrelevant features.

The feature codes of stimuli and responses can be integrated, and if a stimulus is repeated it can retrieve the previously integrated response. Furthermore, even irrelevant features can be integrated and, upon repetition, retrieve the response. Yet the role of attention in feature integration and retrieval is not clearly understood. Some theories assume a central role of attention (e.g., Logan, 1988; Treisman & Gelade, 1980), but other studies have shown no influence of attention on feature binding (e.g., Hommel, 2005). In the present experiments the effect of attention on the integration of two different response-irrelevant features of the same stimulus was examined. In two experiments, participants responded to the color (response feature) of word stimuli, while two irrelevant features of the words (word type and valence) were systematically varied. Participants' attention was directed to either one or the other of the response-irrelevant features by asking participants to report that feature at the end of the trial. Feature-response binding effects in the color task were observed to be stronger for the attended response-irrelevant feature. These results indicate that feature binding is not only very flexible but also sensitive to the distribution of attention. It is also automatic, in the sense that as long as attention is available, feature binding occurs irrespective of the task-specific demands.

Disentangling inhibition-based and retrieval-based aftereffects of distractors: Cognitive versus motor processes.

Selective attention refers to the ability to selectively act upon relevant information at the expense of irrelevant information. Yet, in many experimental tasks, what happens to the representation of the irrelevant information is still debated. Typically, 2 approaches to distractor processing have been suggested, namely distractor inhibition and distractor-based retrieval. However, it is also typical that both processes are hard to disentangle. For instance, in the negative priming literature (for a review Frings, Schneider, & Fox, 2015) this has been a continuous debate since the early 1980s. In the present study, we attempted to prove that both processes exist, but that they reflect distractor processing at different levels of representation. Distractor inhibition impacts stimulus representation, whereas distractor-based retrieval impacts mainly motor processes. We investigated both processes in a distractor-priming task, which enables an independent measurement of both processes. For our argument that both processes impact different levels of distractor representation, we estimated the exponential parameter (τ) and Gaussian components (µ, σ) of the exponential Gaussian reaction-time (RT) distribution, which have previously been used to independently test the effects of cognitive and motor processes (e.g., Moutsopoulou & Waszak, 2012). The distractor-based retrieval effect was evident for the Gaussian component, which is typically discussed as reflecting motor processes, but not for the exponential parameter, whereas the inhibition component was evident for the exponential parameter, which is typically discussed as reflecting cognitive processes, but not for the Gaussian parameter. (PsycINFO Database Record

Five shades of grey: Generalization in distractor-based retrieval of S-R episodes.

Binding theories assume that a stimulus and a response made to it are bound together, as in the case of the theory of event coding, in an event file (Hommel, Müsseler, Aschersleben, & Prinz, Behavioral and Brain Sciences, 24(05), 849-937, 2001). This binding occurs after even a single encounter with the stimulus and the response. Repeating any part of the event file will cause the entire file to be retrieved. However not only are relevant stimuli bound with responses but even irrelevant stimuli that co-occur with the target can be bound with the response, and repeating such a distractor will result in the event file being retrieved. Yet previous studies focused on retrieval effects due to repetition of the same distractor. In this experiment we analysed whether perceptually similar distractors still influence actions due to distractor-based retrieval of responses. Thirty-one participants responded to the shape of the stimulus while ignoring the luminance (5 different shades of grey). The similarity of the stimulus luminance between two consecutive trials influenced response times on response repetition trials. Response repetition effects were particularly facilitated with exact repetitions of the irrelevant feature luminance, and the strength of this effect diminished with increasing dissimilarity of luminance in a linear fashion. We conclude that response-retrieval effects due to distractor bindings follow the rules of generalization, as discussed in the conditioning literature.