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1.
Histopathology ; 42(5): 498-502, 2003 May.
Artículo en Inglés | MEDLINE | ID: mdl-12713628

RESUMEN

AIMS: The differentiation of benign pleural conditions from malignant mesothelioma may be difficult, especially with a small biopsy. We have tested the hypothesis that assessment of the cell cycle status is of value in the histopathological diagnosis of such biopsies, by comparing 33 malignant mesotheliomas with 36 cases of reactive mesothelial hyperplasia and reactive pleural fibrosis. METHODS AND RESULTS: Biopsies were investigated for proliferative status by immunostaining for a novel antibody, MCM2, all of which showed nuclear expression of MCM2 at higher frequency than Ki67 (P < 0.0001). Counts in areas of maximum tumour staining showed significantly higher labelling indices (LIMax) in epithelioid and sarcomatoid mesotheliomas compared with reactive mesothelial hyperplasia and reactive pleural fibrosis (P < 0.0001 for both). Average counts (LIAve) revealed a significant increase in epithelioid mesothelioma compared with reactive mesothelial hyperplasia (P < 0.0001). CONCLUSION: We consider MCM2 to be a useful adjunct in the differential diagnosis of malignant mesothelioma.


Asunto(s)
Ciclo Celular , Epitelio/patología , Mesotelioma/patología , Pleura/patología , Neoplasias Pleurales/patología , Biomarcadores de Tumor/metabolismo , Biopsia , Recuento de Células , Diagnóstico Diferencial , Fibrosis/patología , Humanos , Hiperplasia/patología , Técnicas para Inmunoenzimas , Antígeno Ki-67/metabolismo , Mesotelioma/metabolismo , Componente 2 del Complejo de Mantenimiento de Minicromosoma , Proteínas Nucleares/metabolismo
4.
J Clin Pathol ; 55(7): 499-502, 2002 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-12101193

RESUMEN

BACKGROUND: There is current heightened public interest in issues surrounding death certification and necropsy. The present study was initiated to determine the accuracy of death certification in providing a correct diagnosis in a series of adult deaths occurring in hospital, all of which were followed by a necropsy. METHOD: We examined a series of 440 consecutive adult hospital necropsies performed at Addenbrooke's Hospital, without prior knowledge of the cause of death on the death certificate. The major causes of death at necropsy were subdivided on the basis of organ systems and subsequently compared with the cause of death stated on the death certificate. RESULTS: There were 448 stated causes of death on the death certificates, compared with 508 causes recorded at necropsy. The overall sensitivity of the death certificate in predicting an individual cause of death was 0.47, with sensitivities ranging from 0.90 in the neurological system to 0.28 in the cardiovascular system, and the sensitivity for all malignant causes of death was 0.65. No significant overall differences were noted in respiratory, gastrointestinal, malignant, and "other" systems when comparing causes of death on the death certificate with those at necropsy. CONCLUSIONS: There is a substantial discrepancy between the diagnosis given on death certificates compared with that at hospital necropsy. This paper discusses the importance of clinicopathological concordance and emphasises the importance of the necropsy in death certification.


Asunto(s)
Autopsia , Certificado de Defunción , Hospitales/normas , Adulto , Anciano , Anciano de 80 o más Años , Causas de Muerte , Inglaterra , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Sensibilidad y Especificidad
5.
J Clin Pathol ; 55(7): 551-3, 2002 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-12101210

RESUMEN

This report describes a case of mucinous carcinoma and Müllerian metaplasia arising within an appendiceal duplication cyst found incidentally during an emergency Caesarian section. Intestinal duplication cysts are rare and although there are occasional reports of malignant transformation, this is the first case where Müllerian metaplasia was found concurrently with a malignancy. There was no previous history of endometriosis and no other abnormalities were found at surgery. Treatment included surgical excision. The patient is alive and well two years after removal of the cyst.


Asunto(s)
Adenocarcinoma Mucinoso/patología , Neoplasias del Apéndice/patología , Apéndice/patología , Quistes/patología , Conductos Paramesonéfricos/patología , Complicaciones Neoplásicas del Embarazo/patología , Adulto , Femenino , Humanos , Metaplasia , Embarazo
6.
J Endocrinol Invest ; 22(4): 262-5, 1999 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-10342359

RESUMEN

The prevalence of thyroid nodules is increased in patients with Cushing's disease, but the possibility of an association between thyroid and adrenal nodules in other patient groups has not been formally tested. We have evaluated the co-existence of thyroid and adrenal nodules in retrospective and prospective autopsy studies. Retrospective (83 autopsies) and prospective (29 autopsies) blinded studies of thyroid and adrenal gland histopathology were performed by two experienced histopathologists in unselected autopsies. The presence of nodules, defined as areas of tissue having discrete edges within the gland parenchyma seen as a step difference between the cells or architecture adjacent to the nodule, was determined for each gland. No association was found between the presence of adrenal and thyroid nodules in either the retrospective or prospective studies (p>0.2 for both). In the retrospective study, 23% of specimens had thyroid nodules and 28% adrenal nodules. In the prospective study, 24% of specimens had thyroid nodules and 7% adrenal nodules. The proportion of patients with adrenal nodules in the prospective study was significantly less than that in the retrospective study. In conclusion, thyroid and adrenal nodules are frequent autopsy findings in the general population but we have found no evidence of a relationship between the occurrence of nodules in these glands.


Asunto(s)
Enfermedades de las Glándulas Suprarrenales/patología , Glándulas Suprarrenales/patología , Nódulo Tiroideo/complicaciones , Nódulo Tiroideo/patología , Enfermedades de las Glándulas Suprarrenales/complicaciones , Anciano , Distribución de Chi-Cuadrado , Femenino , Humanos , Masculino , Persona de Mediana Edad , Tamaño de los Órganos , Estudios Prospectivos , Estudios Retrospectivos , Método Simple Ciego , Glándula Tiroides/patología
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