RESUMEN
Activity of glutathione-dependent antioxidant enzymes (glutathione peroxidase, glutathione reductase, and glutathione transferase) in blood erythrocytes from female Macaca mulatta (6-8 and 20-26 years) was measured during activation of the hypothalamic-pituitary-adrenal system under conditions of acute psychoemotional stress (2-h restraint stress). Glutathione reductase activity increased during stress, depended on the time of day, and strongly correlated with blood corticosteroid level. Circadian variations in stress reactivity of glutathione reductase during aging were accompanied by similar changes in stress reactivity of the hypothalamic-pituitary-adrenal system.
Asunto(s)
Envejecimiento , Antioxidantes/metabolismo , Glutatión/metabolismo , Sistema Hipotálamo-Hipofisario/metabolismo , Sistema Hipófiso-Suprarrenal/metabolismo , Estrés Fisiológico/fisiopatología , Animales , Ritmo Circadiano , Femenino , Glutatión/sangre , Glutatión Peroxidasa/sangre , Glutatión Reductasa/sangre , Glutatión Transferasa/sangre , Haplorrinos , Hidrocortisona/sangre , Restricción Física/efectos adversos , Estrés Fisiológico/etiologíaRESUMEN
Age-specific differences in the reaction of the hypothalamic-pituitary-adrenal system to acute psychoemotional stress (immobilization) was studied in female rhesus macaques aged 6-8 and 20-27 years at different time of the day. The reactivity of the hypothalamic-pituitary-adrenal system during immobilization at 15.00 was lower in old animals, while at 9.00 there were no age-specific differences or the reactivity was higher in old animals.
