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Sci Rep ; 13(1): 20216, 2023 11 18.
Artículo en Inglés | MEDLINE | ID: mdl-37980443

RESUMEN

The presynaptic release apparatus can be specialized to enable specific synaptic functions. Habituation is the diminishing of a physiological response to a frequently repeated stimulus and in Aplysia, habituation to touch is mediated by a decrease in transmitter release from the sensory neurons that respond to touch even after modest rates of action potential firing. This synaptic depression is not common among Aplysia synaptic connections suggesting the presence of a release apparatus specialized for this depression. We found that specific splice forms of ApCaV2, the calcium channel required for transmitter release, are preferentially used in sensory neurons, consistent with a specialized release apparatus. However, we were not able to find a specific ApCaV2 splice uniquely required for synaptic depression. The C-terminus of ApCaV2 alpha1 subunit retains conserved binding to Aplysia rab-3 interacting molecule (ApRIM) and ApRIM-binding protein (ApRBP) and the C-terminus is required for full synaptic expression of ApCaV2. We also identified a splice form of ApRIM that did not interact with the ApCav2 alpha 1 subunit, but it was not preferentially used in sensory neurons.


Asunto(s)
Aplysia , Canales de Calcio , Animales , Canales de Calcio/genética , Canales de Calcio/metabolismo , Aplysia/metabolismo , Células Receptoras Sensoriales/metabolismo , Isoformas de Proteínas/genética , Isoformas de Proteínas/metabolismo , Potenciales de Acción , Transmisión Sináptica/fisiología , Sinapsis/metabolismo , Calcio/metabolismo
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