Emotional worlds colliding: A qualitative exploration of the emotional experiences of transgender and cisgender women in romantic relationships during transition.

Relationships in which one partner is transgender are often more complex compared to other LGBQ+ couples, due to the ways in which gender transition prompts changes for each partner and their relationship. Despite the impact of transition on both partners, the relationships of transgender people have been underresearched. This study was guided by symbolic interactionism to explore how transgender and cisgender women in romantic relationships experienced their relationship during their transition process. Constructivist grounded theory was used to analyze interviews with 20 transgender and cisgender participants using group-level analysis. Both groups described their journeys in terms of emotional tensions that ebbed and flowed across time. Participants reflected on how they experienced tensions internally and within their relationships as they worked through change and created meaning from their experiences. Recommendations for research and clinical work are provided, in light of these findings.

Demonstrating Attachment-Based Family Therapy for Transgender and Gender Diverse Youth with Suicidal Thoughts and Behavior: A Case Study.

Suicide is a growing public health issue among adolescents. While the majority of transgender and gender diverse (TGD) youth are healthy, many experience suicidal thoughts and behavior (STB). Due to discrimination and stigma, TGD youth attempt suicide at higher rates then heterosexual, cisgender and even cisgender, LGBQ youth. Despite this vulnerability to suicide, few treatments have been developed and tested for this population. One treatment, attachment-based family therapy (ABFT) has been adapted to work with LGBQ youth and may be promising for TGD adolescents at risk for suicide. This article provides an overview of our ABFT modifications for TGD youth with thoughts of suicide. Specifically, we illustrate how treatment outcomes, in a single case study, relate to processes within clinical treatment tasks. The case study demonstrates the application of these ABFT modifications with a self-identified, gender nonconforming adolescent (who had recently attempted suicide) and his caregivers. Treatment evaluation measures were collected over the course of 24 weeks to illustrate the youth's clinical progress. The youth's suicidal symptoms diminished markedly by the end of treatment. Further, the family reported an increased ability for problem solving and more open communication by treatment conclusion.

El suicidio es un problema de salud pública cada vez mayor entre los adolescentes. Si bien la mayoría de los jóvenes transgénero y de géneros diversos (TGD) son saludables, muchos tienen pensamientos y conductas suicidas. Debido a la discriminación y al estigma, los índices de intento de suicidio en los jóvenes TGD son más altos que en los jóvenes heterosexuales, cisgénero e incluso LGBQ cisgénero. A pesar de esta vulnerabilidad al suicidio, se han desarrollado y se han evaluado pocos tratamientos para esta población. Un tratamiento, la terapia familiar basada en el apego (TFBA), se ha adaptado para trabajar con jóvenes LGBQ y puede ser prometedor para adolescentes TGD en riesgo de suicidio. Este artículo ofrece un resumen de nuestras modificaciones a la TFBA para los jóvenes TGD con pensamientos de suicidio. Específicamente, ilustramos cómo los resultados del tratamiento, en un solo caso práctico, se relacionan con los procesos dentro de las tareas del tratamiento clínico. El caso práctico demuestra la aplicación de estas modificaciones de la TFBA con un adolescente que se identificó como de género no conforme (y que recientemente había intentado suicidarse) y sus cuidadores. Se recopilaron las valoraciones de una evaluación del tratamiento durante el transcurso de 24 semanas para ilustrar el avance clínico del joven. Los síntomas de suicidio del joven disminuyeron notablemente al final del tratamiento. Además, la familia informó una mayor capacidad para resolver problemas y una comunicación más abierta al concluir el tratamiento.

Methylpyrrole inhibitors of BET bromodomains.

An NMR fragment screen for binders to the bromodomains of BRD4 identified 2-methyl-3-ketopyrroles 1 and 2. Elaboration of these fragments guided by structure-based design provided lead molecules with significant activity in a mouse tumor model. Further modifications to the methylpyrrole core provided compounds with improved properties and enhanced activity in a mouse model of multiple myeloma.

A modified yolk biopsy technique improves survivorship of turtle eggs.

Nongenetic maternal contributions, such as steroid hormones, have received much attention in recent years because they have the potential to influence offspring phenotype. Research in oviparous taxa has demonstrated that there is among-species variability in their response to these maternal contributions. However, studies in chelonians and crocodilians have been hampered by the fact that techniques involving egg manipulations that breach the eggshell routinely result in massive egg mortality. In this study, we present an improved yolk manipulation technique that resulted in increased egg survival (in excess of 70% survival) in the red-eared slider turtle (Trachemys scripta) and that may be broadly applicable to other species. By elevating survival to a level on par with other oviparous taxa, this method permits a more thorough exploration of reptilian egg physiology and allows for studies that examine traits in both the egg and the resulting hatchling.