Asunto(s)
Ensayos Clínicos como Asunto , Neoplasias del Sistema Nervioso/terapia , Proyectos de Investigación , Resultado del Tratamiento , Ensayos Clínicos como Asunto/métodos , Ensayos Clínicos como Asunto/normas , Ensayos Clínicos como Asunto/estadística & datos numéricos , Supervivencia sin Enfermedad , Humanos , Neoplasias del Sistema Nervioso/diagnóstico , Pronóstico , Calidad de VidaAsunto(s)
Extremidades/cirugía , Recurrencia Local de Neoplasia , Sarcoma , Neoplasias de los Tejidos Blandos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Terapia Combinada , Supervivencia sin Enfermedad , Extremidades/patología , Extremidades/efectos de la radiación , Femenino , Humanos , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia/patología , Recurrencia Local de Neoplasia/radioterapia , Recurrencia Local de Neoplasia/cirugía , Estadificación de Neoplasias , Sarcoma/patología , Sarcoma/radioterapia , Sarcoma/cirugía , Neoplasias de los Tejidos Blandos/patología , Neoplasias de los Tejidos Blandos/radioterapia , Neoplasias de los Tejidos Blandos/cirugía , Resultado del TratamientoRESUMEN
The efficacy of parallel and successive chemoradial treatment of patients with nasopharynx carcinoma was investigated in the radiological center of Burdenko MMCH. The main group consisted of 42 patients, the control group included 44 patients. They were from 21 to 78 years old. 71% of the patients had the 3rd and the 4th stages of the tumor process; 29% had the 1st and the 2nd stages; 68,6% had the metastatic nodal involvement of regional zones. The radial therapy of the locoregional zone was administered by means of the splitting course using the classic method of fractionating a dose up to the total optimal dose of 64-70 Gr. Polychemotherapy consisted of 6 courses cisplatin, farmarubicin, and platinum. Due to the treatment the 5-year survival rate increased from 41,2% to 78,5% (P < 0,001). With the metastatic nodal involvement of regional zones that rate reduced from 83,3% to 72,8% (P > 0,05) in the main group and from 63,8% to 31,9% (P < 0,001) in the control group.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Nasofaríngeas/tratamiento farmacológico , Neoplasias Nasofaríngeas/radioterapia , Adulto , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/efectos adversos , Cisplatino/administración & dosificación , Cisplatino/efectos adversos , Terapia Combinada , Supervivencia sin Enfermedad , Epirrubicina/administración & dosificación , Epirrubicina/efectos adversos , Femenino , Fluorouracilo/administración & dosificación , Fluorouracilo/efectos adversos , Humanos , Masculino , Persona de Mediana Edad , Neoplasias Nasofaríngeas/patología , Metástasis de la Neoplasia , Estadificación de Neoplasias , Dosis de RadiaciónAsunto(s)
Neurofibromatosis/diagnóstico , Adulto , Diagnóstico Diferencial , Genes de Neurofibromatosis 1 , Genes de la Neurofibromatosis 2 , Humanos , Imagen por Resonancia Magnética , Masculino , Mutación , Neoplasias de la Vaina del Nervio/diagnóstico , Neoplasias de la Vaina del Nervio/genética , Neurofibromatosis/genética , Neurofibromatosis 1/diagnóstico , Neurofibromatosis 1/genética , Neurofibromatosis 2/diagnóstico , Neurofibromatosis 2/genéticaRESUMEN
Multiple myeloma (MM) is B-cellular lymphoproliferative disease. We studied 174 patients aged 33-84 with established diagnosis of MM. Among the persons included into analyzed cohort the data about the presence of polyneuropathy at the moment of MM verification were available in 72 (41.4%) persons. Spinal cord involvement due to the various pathogenetic reasons was revealed in 24 (13.8 +/- 2.6%) patients. Compressional alteration was observed in 19 cases and in 5 patients the spinal cord involvement had uncompressional genesis. The connection between the peripheral polyneuropathy and the unfavourable prognosis in MM patients was statistically insignificant. In the patients with spinal cord prelum the probability of lethal outcome within 1 month was 0.26. It is 10 times more than in patients suffering only from peripheral polyneuropathy. Thus polyneuropathy in MM patients occurs in 41.4 +/- 3.7% cases and more often during the III stage of disease. There is a distinct interrelation between the nervous trunk involvement and disease severity. In the structure of polyneuropathy the sensorimotor variant (76.4 +/- 5.0%) prevails. According to our data the spinal cord involvement occurs in 13.8 +/- 2.6% cases.
