RESUMEN
We report the case of a giant lipoma of the quadrigeminal cistern in a 30-year-old female patient with headache, nausea, vomiting, and phono and photophobia. Despite the large size of the tumor, conservative treatment was chosen. Intracranial lipomas are rare benign tumors commonly associated with congenital anomalies, and their origin is related to an incorrect embryonic development. The diagnosis is made mainly by cranial computed tomographyand magnetic resonance imaging. The treatment of lipoma can be surgical or conservative, and there is no single treatment for the different patients' cases.
Relatamos o caso de um lipoma gigante de cisterna quadrigeminal em uma paciente de 30 anos, do sexo feminino, com cefaleia, náusea, fono e fotofobia, no qual se optou pelo tratamento conservador. Os lipomas intracranianos são tumores benignos raros comumente associados a anomalias congênitas, e sua origem relaciona-se ao mau desenvolvimento embrionário. A investigação diagnóstica é feita predominantemente através da tomografia computadorizada e ressonância nuclear magnética do crânio, e não existe um tratamento único para os diferentes quadros dos pacientes.
RESUMEN
Algorithms can have several purposes in the clinical practice. There are different scales for causality imputation in DILI (Drug-Induced Liver Injury), but the applicability and validity of these for the HILI (Herb-Induced Liver Injury) evaluation is questionable for some scales. The purpose of the study was to determine the clinical and demographic profile of the patients with HILI, and the main algorithmic scales used in its causality assessment. The methodology was a systematic review of articles in English, Spanish, or Portuguese language, from 1979 to 2019, involving humans, with descriptors related to HILI. Qualitative and quantitative statistical analysis were performed. As a result, from a total of 60 articles, 203 HILI reports were selected: 59.9% were women, similar with other studies, and the average age was 45.8 years. Jaundice was the most frequent symptom and regarding the type of lesion, the hepatocellular was the most frequent. In regard to HILI severity, 3.0% were severe and 7.6% were fatal or required liver transplantation. In 72.3% of the cases, the most used algorithm was RUCAM (Roussel Uclaf Causality Assessment Method). The conclusion of the study is that RUCAM was the most used algorithm for causality assessment in HILI. The patients were predominantly female, jaundice was the main symptom, and HILI is reversible in the majority of cases.
