[Experience in using an autovaccine in treating patients with chronic osteomyelitis]. / Opyt primeneniia autovaktsiny v lechenii bol'nykh khronicheskim osteomielitom.

Autovaccine immunization (AI) of 60 patients with chronic osteomyelitis resulted in 93% success (significant in 43%) in formerly failures both with surgical and medical treatment. The method of manufacturing the autovaccine is described, immunization schemes are given.

[Diagnosis of Campylobacter pylori based on the level of urea in the gastric juice]. / Diagnostika Campylobacter pylori po urovniu mocheviny v zheludochnom soke.

Comparison of urea levels in 3 portions of gastric juice, obtained on an empty stomach, basal, and stimulated, from 28 patients, C. pylori carriers, and 20 patients without C. pylori carriership, has shown that the presence of this bacterium in the gastric mucosa is related not so much with a decrease in the absolute level of urea in the portion collected on an empty stomach but mostly with changes in this parameter in three portions of gastric juice collected in succession. Decreased urea levels in the second portion as against the first one or in the third one as against the two previous ones were detected in 97% of patients with C. pylori carriership. In 100% of patients without C. pylori carriership urea levels in the three portions remained unchanged or were decreasing. The method for measuring urea levels in three portions of gastric juice is recommended for the diagnosis of C. pylori carriership in gastroduodenal diseases.

[Assessment of methods of rapid diagnosis of Campylobacter pylori in duodenal ulcers]. / Otsenka metodov uskorennoi diagnostiki Campylobacter pylori pri iazvennoi bolezni dvenadtsatiperstnoi kishki.

A study of diagnostic value of the Campylobacter pylori test as well as microbiological, bacteriological and biochemical findings in 134 patients with gastroduodenal ulcer and 20 healthy persons indicates that association of the Campylobacter pylori and biochemical tests are reliable and may be recommended for wide use in practical public health.

[Epidemiological study of the associations of Staphylococcus aureus and Pseudomonas aeruginosa in the pulmonology clinic]. / Epidemiologicheskoe izuchenie assotsiatsii Staphylococcus aureus i Pseudomonas aeruginosa v pul'monologicheskoi klinike.

The results of the five-year study of S. aureus and P. aeruginosa associations isolated from the sputa of pulmonological patients are presented. The incidence rate of these bacteria in monocultures and associations is estimated. The results of the phage typing and serotyping of S. aureus and P. aeruginosa strains suggest that the formation of the associations of these organisms occurs mainly due to the tendency of P. aeruginosa hospital strains to associate with S. aureus cultures present in the patients.

[Combined effect of ethonium and antibiotics on Pseudomonas aeruginosa]. / Kombinirovannoe deistvie étoniia s antibiotikami na Pseudomonas aeruginosa.

The combined effect of ethonium and 5 antibiotics belonging to different groups was studied with 30 clinical strains of P. aeruginosa. A 2--8-fold increase in the activity of kanamycin and tetracycline against some strains was observed. The MIC of carbenicillin, polymycin M and cefotaxime was lowered by 2--6 times and with respect to some strains by 16--32 times. The detergent is recommended to be used in combination with some antibiotics in treatment of infections caused by resistant strains of P. aeruginosa.

[Pathogenicity factors of melanin-forming strains of Pseudomonas aeruginosa]. / Faktory patogennosti melaninobrazuiushchikh shtammov Pseudomonas aeruginosa.

The data on the capacity of 50 melanogenic and 50 amelanogenic P. aeruginosa strains to produce hemolysins, gelatinase, caseinase, DNAase, RNAase, lecithinase, elastase, neuraminidase and to form extracellular slime, obtained in the comparative study of these strains in vitro, are presented. Melanogenic P. aeruginosa cultures were found to have a higher lecithinase and neuraminidase activity. The strains incapable of melanogenesis formed slime more frequently. The properties of the strains in respect to other pathogenicity characteristics under study were identical.

[Comparison of the sensitivity of Pseudomonas aeruginosa cultures that synthesize melanin and other pigments to 12 antibiotics and 5-nitro-8-quinolinol]. / Sravnenie chuvstvitel'nosti kul'tur Pseudomonas aeruginosa, sinteziruiushchikh melanin in drugie pigmenty, k 12 antibiotikam i 5-NOK.

Sensitivity of 80 Pseudomonas aeruginosa cultures forming melanin and 80 cultures synthesizing other pigments to amikacin, gentamicin, kanamycin, carbenicillin, levomycetin, monomycin, 5-NOK, polymyxin M, rifampicin, streptomycin, tetracycline, tobramycin and erythromycin was determined. It was found that the cultures of Ps. aeruginosa synthesizing melanin were less resistant to most of the antibiotics that the other representatives of this species.

[Gentamycin activity in combination with etonium in relation to Pseudomonas aeruginosa]. / Aktivnost' gentamitsina v sochetanii s étoniem v otnoshenii Pseudomonas aeruginosa.

Gentamicin is one of the most effective drugs for treatment of infections caused by Ps. aeruginosa. However, isolation of the strains resistant to the antibiotics was not infrequent. It was shown in the experiments with 40 cultures that the activity of gentamicin against Ps. aeruginosa increased approximately 20 times when it was used in combination with ethonium, a derivative of bis-quaternary ammonium compounds.