1.
Bioorg Med Chem Lett
; 22(21): 6628-31, 2012 Nov 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23025999
RESUMEN
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and selective DPP-4 inhibitors.