1.
Cancer Sci
; 103(4): 626-31, 2012 Apr.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22212856
RESUMEN
The so-called "seed and soil" hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to "selected" sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy?