Characteristics and outcomes of pediatric oncology patients at risk for guardians declining transfusion of blood components.

BACKGROUND: Transfusion of blood products is a necessary part of successful delivery of myelosuppressive regimens in pediatric cancer. There is a paucity of literature characterizing outcomes or management of pediatric patients with cancer when transfusion is declined. AIMS: The objective of this paper is to describe the clinical characteristics, care, and outcomes of patients with cancer at risk for declining transfusion. METHODS AND RESULTS: A retrospective cohort of patients aged 0-21 years with cancer managed at Children's Healthcare of Atlanta between 2006 and 2020 and with ICD-9 codes indicating risk of "transfusion refusal" or Jehovah's witness (JW) religion was identified. Demographics, disease, and management were abstracted. Descriptive statistics were performed to examine associations with transfusion receipt. Among 35 eligible patients identified as at risk for declining transfusion, 89% had primary guardians who identified as JW, and 45.7% identified as Black, non-Hispanic. Only 40% of guardians actively declined transfusion. Transfusion recipients had significantly lower hemoglobin (g/dl) and platelet counts (1000/µl) at initial presentation (9.6 vs. 11.9, p < .002 and 116.0 vs. 406.5, p = .001, respectively) and at nadir (5.9 vs. 8.7, p < .001 and ≤ 10 vs. 154, p < .001, respectively) than non-recipients. Legal intervention was required in 36.4% of those who ultimately received a transfusion. CONCLUSION: Among pediatric cancer patients whose medical record initially indicated a preference for no transfusion, 60% of guardians accepted blood products when prescribed for oncology care. Guidelines for systematic management and transfusion sparing approaches are needed to honor guardian's preferences when possible yet while maintaining equitable cancer outcomes in this population.

CDE and non-CDE dietitians' knowledge of exercise and content of exercise programs for older adults with type 2 diabetes.

OBJECTIVE: To study differences between non-certified diabetes educator registered dietitians (non-CDE-RDs) and certified diabetes educator registered dietitians (CDE-RDs) in the design and content of programs to promote physical activity in older adults with type 2 diabetes. DESIGN: The Exercise Teaching Questionnaire was used to assess knowledge of and promotion of physical activity. SETTING AND PARTICIPANTS: Surveys were sent to CDE-RDs and non-CDE-RDs in Florida, California, and Texas. Ninety-four CDE-RDs and 73 non-CDE-RDs completed the study. MAIN OUTCOME MEASURES: The independent variable was CDE status. The dependent variables were knowledge, design, content, and total exercise scores. ANALYSIS: Two-way ANOVA's tested for Knowledge, Design, and Content scores by RD status and one of the following: years practicing in diabetes education, state, and practice setting. RESULTS: The exercise Knowledge, Design and Content scores were significantly (P < .001) higher in the CDE-RDs compared to those of the non-CDE-RDs. CONCLUSIONS AND IMPLICATIONS: The results of this study indicate that education and experience play a key role in the design and content of programs to promote physical activity in older adults. Therefore, the results raise the question of the role the dietitian and nutrition educator should play in the promotion of physical activity in older adults.