All-fiber polarization-maintaining mode-locked laser operated at 980 nm.

For the first time, to the best of our knowledge, we present an all-fiber polarization-maintaining passively mode-locked picosecond laser operated at 980 nm. The laser cavity had a ring configuration with a semiconductor saturable absorber mirror as a mode-locking element. As an active medium, we used a specially designed cladding-pumped Yb-doped fiber with reduced cladding-to-core diameter ratio. The laser was self-starting and operated in the net cavity normal dispersion regime, where a spectral profile of the gain medium acted as a filter element. By intracavity spectral filtering, we achieved about 40 dB dominance of the signal wavelength at 980 nm over 1 µm emission in a highly stable picosecond pulsed regime. The corresponding simulation was performed to extend the knowledge about laser operation.

Author Correction: The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The light-oxygen effect in biological cells enhanced by highly localized surface plasmon-polaritons.

Here at the first time we suggested that the surface plasmon-polariton phenomenon which it is well described in metallic nanostructures could also be used for explanation of the unexpectedly strong oxidative effects of the low-intensity laser irradiation in living matters (cells, tissues, organism). We demonstrated that the narrow-band laser emitting at 1265 nm could generate significant amount of the reactive oxygen species (ROS) in both HCT116 and CHO-K1 cell cultures. Such cellular ROS effects could be explained through the generation of highly localized plasmon-polaritons on the surface of mitochondrial crista. Our experimental conditions, the low-intensity irradiation, the narrow spectrum band (<4 nm) of the laser and comparably small size bio-structures (~10 µm) were shown to be sufficient for the plasmon-polariton generation and strong laser field confinement enabling the oxidative stress observed.

Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c nude mouse model involves activation of the cell antioxidant system.

Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.