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Curr Biol ; 30(2): 196-208.e8, 2020 01 20.
Artículo en Inglés | MEDLINE | ID: mdl-31902720

RESUMEN

The widespread availability of energy-dense, rewarding foods is correlated with the increased incidence of obesity across the globe. Overeating during mealtimes and unscheduled snacking disrupts timed metabolic processes, which further contribute to weight gain. The neuronal mechanism by which the consumption of energy-dense food restructures the timing of feeding is poorly understood. Here, we demonstrate that dopaminergic signaling within the suprachiasmatic nucleus (SCN), the central circadian pacemaker, disrupts the timing of feeding, resulting in overconsumption of food. D1 dopamine receptor (Drd1)-null mice are resistant to diet-induced obesity, metabolic disease, and circadian disruption associated with energy-dense diets. Conversely, genetic rescue of Drd1 expression within the SCN restores diet-induced overconsumption, weight gain, and obesogenic symptoms. Access to rewarding food increases SCN dopamine turnover, and elevated Drd1-signaling decreases SCN neuronal activity, which we posit disinhibits downstream orexigenic responses. These findings define a connection between the reward and circadian pathways in the regulation of pathological calorie consumption.


Asunto(s)
Dopamina/fisiología , Transducción de Señal , Núcleo Supraquiasmático/fisiología , Aumento de Peso/fisiología , Animales , Ingestión de Alimentos , Conducta Alimentaria , Expresión Génica , Masculino , Ratones , Ratones Endogámicos C57BL , Distribución Aleatoria , Receptores de Dopamina D1/genética , Receptores de Dopamina D1/metabolismo , Recompensa , Aumento de Peso/genética
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