RESUMEN
A new diarylhexane, kneglobularone B (1) and two new diarylpropanols, kneglobularols A - B (2 - 3) along with seven known compounds (4 - 10) were isolated and characterized from the roots of Knema globularia. It is the first time to find arylpropyl quinone (4) and isoflavone (8) in Myristicaceae family. In addition, 5 was found for the first time in Knema genus. Their structures were elucidated by UV, IR, MS, 1 D and 2 D NMR techniques. Compound 4 exhibited strong cytotoxicity against the NCI - H187 and MCF - 7 cell lines with IC50 values of 3.08 and 6.68 µg/mL, respectively.
Asunto(s)
Myristicaceae , Plantaginaceae , Línea Celular Tumoral , Humanos , Células MCF-7 , Estructura Molecular , Myristicaceae/química , Extractos Vegetales/química , Raíces de Plantas/químicaRESUMEN
Four new acylphloroglucinol derivatives 1, 3, 5 and 13 were isolated from the fruits of Horsfieldia irya, and in addition, thirteen known compounds were also discovered. All compounds were evaluated for cytotoxicity against HeLa and HCT116 cell lines, as well as normal cells (Vero cells). Compound 13 showed cytotoxicity against HeLa and HCT116 cell lines with IC50 values of 4.53 ± 0.05 and 4.53 ± 0.16 µg/mL, respectively, and showed less activity against normal cells (IC50 = 13.38 ± 0.75 µg/mL). Compound 13 may be useful for the development of anticancer agents. It was found that decanoyl side chain may be necessary for the cytotoxicity. The chemical structures of all isolated compounds were elucidated using spectroscopic methods including 1 D-NMR, 2 D-NMR, MS and IR data.
Asunto(s)
Antineoplásicos Fitogénicos , Myristicaceae , Animales , Antineoplásicos Fitogénicos/farmacología , Chlorocebus aethiops , Frutas , Células HCT116 , Humanos , Estructura Molecular , Células VeroRESUMEN
Two new compounds, dalpulanone (1) and 2-hydroxyisomucronustyrene (2), were isolated from the stems of Dalbergia stipulacea. Fourteen known compounds (3-16) were also isolated. The chemical structures of all isolated compounds were elucidated using spectroscopic methods, including 1D-NMR, 2D-NMR, MS and IR data. Compound 4 displayed the strongest antifungal activity against Pythium insidiosum and had higher activity than the amphotericin-B standard.
Asunto(s)
Antifúngicos/farmacología , Dalbergia , Pythium , Antifúngicos/aislamiento & purificación , Dalbergia/química , Espectroscopía de Resonancia Magnética , Estructura Molecular , Fitoquímicos/aislamiento & purificación , Fitoquímicos/farmacología , Tallos de la Planta/química , Pythium/efectos de los fármacosRESUMEN
A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4'-dihydroxy-(3â³,4â³-dihydro-3â³,4â³-dihydroxy)-2â³,2â³-dimethylpyrano-(5â³,6â³:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer's disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman's method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity.
Asunto(s)
Antioxidantes/farmacología , Inhibidores de la Colinesterasa/farmacología , Flavonoides/farmacología , Rutaceae/química , Acridonas/química , Acridonas/farmacología , Alcaloides/química , Alcaloides/farmacología , Antioxidantes/química , Inhibidores de la Colinesterasa/química , Evaluación Preclínica de Medicamentos/métodos , Flavonoides/química , Isoflavonas/química , Isoflavonas/farmacología , Espectroscopía de Resonancia Magnética , Estructura Molecular , Extractos Vegetales/farmacología , Hojas de la Planta/químicaRESUMEN
A new coumarin, scataccanol (1) and 10 known compounds were isolated from the fruits of Scaevola taccada (Gaertn.) Roxb. All compounds were evaluated for antifungal activity against Pythium insidiosum. Compounds 5 and 7 showed strong antifungal activity with minimum inhibitory concentration values of 5 and 10 µg/mL, respectively. Structural determination of all compounds was accomplished by 1D and 2D-NMR, IR and MS.
Asunto(s)
Antifúngicos/farmacología , Furocumarinas/aislamiento & purificación , Magnoliopsida/química , Pythium/efectos de los fármacos , Frutas/química , Furocumarinas/química , Furocumarinas/farmacología , Espectroscopía de Resonancia Magnética , Espectrometría de Masas , Pruebas de Sensibilidad MicrobianaRESUMEN
Five new compounds, including pteroloterins A-C (1, 3, and 4), 1ß-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 ± 0.18 µM and showed no activity against normal cells.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Fabaceae/química , Terpenos/aislamiento & purificación , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Neoplasias de los Conductos Biliares , Conductos Biliares Intrahepáticos , Línea Celular Tumoral , Colangiocarcinoma , Ensayos de Selección de Medicamentos Antitumorales , Humanos , Concentración 50 Inhibidora , Estructura Molecular , Osteogénesis/efectos de los fármacos , Corteza de la Planta/química , Relación Estructura-Actividad , Terpenos/química , Terpenos/farmacología , TailandiaRESUMEN
Two new compounds, derrivanone (1) and derrischalcone (2), were isolated from the crude hexane extract of the fruits of Derris indica. In addition, 14 known compounds were isolated from the fruits of this plant. Chalcones 2-4 showed strong cytotoxicity against cholangiocarcinoma cell line (M156) and human hepatoma HepG2 cells. In addition, flavanones 15 and 16 exhibited potent and high cytotoxic efficacy.
Asunto(s)
Antineoplásicos/química , Antineoplásicos/toxicidad , Derris/química , Antineoplásicos/uso terapéutico , Neoplasias de los Conductos Biliares/tratamiento farmacológico , Conductos Biliares Intrahepáticos , Línea Celular Tumoral , Chalconas/química , Colangiocarcinoma/tratamiento farmacológico , Flavanonas/química , Flavanonas/toxicidad , Frutas/química , Células Hep G2 , Humanos , Extractos Vegetales/químicaRESUMEN
Four new compounds, microminutin B (1), microminutin C (2), micromarinate (3), and secomicromelin (4) as well as 17 known compounds were isolated from the fruits of Micromelum falcatum. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. P. insidiosum is a fungus-like microorganism for which antifungal agents now available are not effective. The results show that four compounds including secomicromelin (4), 7-methoxy-8-(4'-methyl-3'-furanyl)coumarin (10), micromarin B (17), and isomicromelin (19) could inhibit the mycelia growth of P. insidiosum.
Asunto(s)
Antifúngicos/química , Cumarinas/química , Extractos Vegetales/química , Pythium/efectos de los fármacos , Rutaceae/química , Antifúngicos/aislamiento & purificación , Antifúngicos/farmacología , Cumarinas/aislamiento & purificación , Cumarinas/farmacología , Relación Dosis-Respuesta a Droga , Frutas/química , Espectroscopía de Resonancia Magnética , Pruebas de Sensibilidad Microbiana , Estructura Molecular , Extractos Vegetales/aislamiento & purificación , Extractos Vegetales/farmacología , Pythium/crecimiento & desarrolloRESUMEN
Thirteen compounds were isolated from the stem of Hymenocardia wallichii Tul. A new phenolic compound, wallinol (1), was found in this plant. The other chemical components were squalene (2), stigmasterol (4), homopterocarpin (5), two triterpenes (3 and 13), two benzaldehyde derivatives (6 and 9), three cinnamyl derivatives (7, 11, and 12), a coumarin (8), and a monoglyceride (10). Their structures were elucidated on the basis of spectroscopic methods including IR, HR-ESI-MS, and 1D and 2D NMR data.
