1.
Chem Commun (Camb)
; 60(6): 706-709, 2024 Jan 16.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38108130
RESUMEN
Herein we introduce 3-vinyl-1,2,4-triazines derivatives as dual-reactive linkers that exhibit selectivity towards cysteine and specific strained alkynes, enabling conjugate addition and inverse electron-demand Diels-Alder (IEDDA) reactions. This approach facilitates site-selective bioconjugation of biologically relevant peptides, followed by rapid and highly selective reactions with bicyclononyne (BCN) reagents.