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1.
PLoS One ; 17(4): e0266111, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35390022

RESUMEN

The progress in translational cancer research relies on access to well-characterized samples from a representative number of patients and controls. The rationale behind our biobanking are explorations of post-zygotic pathogenic gene variants, especially in non-tumoral tissue, which might predispose to cancers. The targeted diagnoses are carcinomas of the breast (via mastectomy or breast conserving surgery), colon and rectum, prostate, and urinary bladder (via cystectomy or transurethral resection), exocrine pancreatic carcinoma as well as metastases of colorectal cancer to the liver. The choice was based on the high incidence of these cancers and/or frequent fatal outcome. We also collect age-matched normal controls. Our still ongoing collection originates from five clinical centers and after nearly 2-year cooperation reached 1711 patients and controls, yielding a total of 23226 independent samples, with an average of 74 donors and 1010 samples collected per month. The predominant diagnosis is breast carcinoma, with 933 donors, followed by colorectal carcinoma (383 donors), prostate carcinoma (221 donors), bladder carcinoma (81 donors), exocrine pancreatic carcinoma (15 donors) and metachronous colorectal cancer metastases to liver (14 donors). Forty percent of the total sample count originates from macroscopically healthy cancer-neighboring tissue, while contribution from tumors is 12%, which adds to the uniqueness of our collection for cancer predisposition studies. Moreover, we developed two program packages, enabling registration of patients, clinical data and samples at the participating hospitals as well as the central system of sample/data management at coordinating center. The approach used by us may serve as a model for dispersed biobanking from multiple satellite hospitals. Our biobanking resource ought to stimulate research into genetic mechanisms underlying the development of common cancers. It will allow all available "-omics" approaches on DNA-, RNA-, protein- and tissue levels to be applied. The collected samples can be made available to other research groups.


Asunto(s)
Neoplasias de la Mama , Carcinoma , Neoplasias Colorrectales , Bancos de Muestras Biológicas , Neoplasias de la Mama/genética , Variación Genética , Humanos , Masculino , Mastectomía , Neoplasias Pancreáticas , Neoplasias Pancreáticas
2.
Materials (Basel) ; 14(16)2021 Aug 09.
Artículo en Inglés | MEDLINE | ID: mdl-34442984

RESUMEN

The numerical simulations of Cu Kα and Cu Kß fluorescence lines induced by Rh X-ray tube and by monoenergetic radiation have been presented. The copper Kß/Kα intensity ratios for pure elements as well as for Ag-Cu alloys have been modeled. The results obtained by use of the FLUKA code, based on the Monte-Carlo approach, have been compared to available experimental and theoretical values. A visible relationship was found between the simulated Kß/Kα intensity ratios and the copper content of the Ag-Cu alloy: as the Cu content increases, the Kß/Kα coefficient decreases. The results can play role in elemental material analysis, especially in archaeometry.

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