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Objective: Comprehensive evaluation of lisedexamfetamine dimesylate (LDX) alone and in combination with topiramate (TPM) was done for treatment of binge eating disorder (BED) in adults aged 18-55 years. Methods: In the present randomized clinical trial study, 93 patients were selected by convenience sampling method and were allocated to two groups of 48 and 45 using the permuted block randomization method. This study was conducted from January to September 2022 in Shiraz, Iran. Patients received LDX (n = 48) or LDX plus TPM. Average dose of LDX was 37.5 mg/day and 38 mg/day in the first and second group respectively. The second group (n = 45) also received TPM with average dose of 77.7 mg/day. Results: Twelve weeks treatment caused significant higher mean reduction in level of triglyceride (73.68 vs. 58.97 respectively, p = 0.024), low density lipo-protein (LDL) (9.66 vs. 5.16 respectively, p < 0.001) and body mass index (5.48 vs. 3.41 respectively, p < 0.001) with TPM plus LDX and also greater significant improvement (p < 0.001) in binge eating scale compared to use of LDX alone. Combination therapy with TPM and LDX had better tolerability and lower adverse events such as insomnia (p < 0.001), paresthesia (p = 0.001), confusion (p = 0.035) and ataxia (p = 0.009) compared to monotherapy in BED. Conclusion: The combinative treatment was more effective than single drug in terms of higher tolerability, safety and causing lesser adverse events for BED patients. However, more studies with larger samples are needed.
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Experimental data on flow patterns and pressure drop in two-phase gas-liquid flows through a packed bed obtained aboard the International Space Station (ISS) are analyzed in the limit of low flow rates. Four distinct flow regimes (dispersed bubble, pulse, elongated or large bubble, and gas continuous) are observed and the transition boundaries are identified by a change in the slope of the pressure gradient versus flow rate. It is found that the pressure drop is a function of flow history with the relative magnitude of the hysteresis decreasing with increasing gas or liquid flow rates. Pressure drop (or friction factor) correlations are presented for each of the flow regimes. The capillary or interfacial contribution to the pressure gradient is found to be dominant in the gas channeling regime but comparable to the viscous contribution in the large bubble regime. Preliminary data indicating the slow accumulation of the gas in the bed in the large bubble regime over a longer time period and the intermittent nature of this regime are also presented.
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Objective: Religious coping is known as one of the successful manners to cure depressed infertile women; however, research findings show that demographic factors (e.g., education level) have played an important role on the relationship between depression and religious coping scores. The goal of this study is to measure the influence of age, job status, and education level on both scores within Iranian infertile women. Method : In this cross sectional study, 1000 women (mean age, 35.96; range, 26-45), who are recruited from different hospitals of Shiraz (Iran), are selected via multistage cluster sampling method. The reliability and validity of the translated versions of the questionnaires have been confirmed. The correlation coefficient (Spearman method), adjusted linear regression coefficient, and ordinal regression coefficient of demographic features with the depression scores/levels (minimal, mild, moderate, and severe) and religious coping scores are determined. Results: A significant negative correlation is found between depression and religious compatibility scores in 1000 infertile women (ρ = -0.318, P = 0.000). In addition, the results have implied the existence of a significant correlation and linear relationship between religious coping and age and job status (P < 0.05). Furthermore, both correlation and ordinal regression of depression intensity with both job status and education level are found to be statistically meaningful (P < 0.05). Conclusion: The negative correlation between religious coping and depression scores has implied the positive role of religious coping in protecting infertile women from depression, especially among employed women. Nevertheless, the correlation of religious coping with education level is not strong enough due to the nonuniform distribution of variables through their range.
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OBJECTIVES: Diagnosis of the psychiatric diseases is a bit challenging at the first interview due to this fact that qualitative criteria are not as accurate as quantitative ones. Here, the objective is to classify schizophrenic patients from the healthy subject using a quantitative index elicited from their electroencephalogram (EEG) signals. METHODS: Ten right handed male patients with schizophrenia who had just auditory hallucination and did not have any other psychotic features and ten age-matched right handed normal male control participants participated in this study. The patients used haloperidol to minimize the drug-related affection on their EEG signals. Electrophysiological data were recorded using a Neuroscan 24 Channel Synamps system, with a signal gain equal to 75K (150 xs at the headbox). According to the observable anatomical differences in the brain of schizophrenic patients from controls, several discriminative features including AR coefficients, band power, fractal dimension, and approximation entropy (ApEn) were chosen to extract quantitative values from the EEG signals. RESULTS: The extracted features were applied to support vector machine (SVM) classifier that produced 88.40% accuracy for distinguishing the two groups. Incidentally, ApEn produces more discriminative information compare to the other features. CONCLUSION: This research presents a reliable quantitative approach to distinguish the control subjects from the schizophrenic patients. Moreover, other representative features are implemented but ApEn produces higher performance due to complex and irregular nature of EEG signals.
