RESUMEN
PURPOSE: Iatrogenic ureteral strictures (US) after endoscopic treatment for urolithiasis represent a significant healthcare concern. However, high-quality evidence on the risk factors associated with US is currently lacking. We aimed to develop a consensus statement addressing the definition, risk factors, and follow-up management of iatrogenic US after endoscopic treatment for urolithiasis. METHODS: Utilizing a modified Delphi method, a steering committee developed survey statements based on a systematic literature review. Then, a two-round online survey was submitted to 25 experts, offering voting options to assess agreement levels. A consensus panel meeting was held for unresolved statements. The predetermined consensus threshold was set at 70%. RESULTS: The steering committee formulated 73 statements. In the initial survey, consensus was reached on 56 (77%) statements. Following in-depth discussions and refinement of 17 (23%) statements in a consensus meeting, the second survey achieved consensus on 63 (86%) statements. This process underscored agreement on pivotal factors influencing US in endoscopic urolithiasis treatments. CONCLUSIONS: This study provides a comprehensive list of categorized risk factors for US following endoscopic urolithiasis treatments. The objectives include enhancing uniformity in research, minimizing redundancy in outcome assessments, and effectively addressing risk factors associated with US. These findings are crucial for designing future clinical trials and guiding endoscopic surgeons in mitigating the risk of US.
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Técnica Delphi , Obstrucción Ureteral , Ureteroscopía , Urolitiasis , Humanos , Urolitiasis/cirugía , Factores de Riesgo , Ureteroscopía/efectos adversos , Obstrucción Ureteral/cirugía , Obstrucción Ureteral/etiología , Constricción Patológica , Complicaciones Posoperatorias/etiología , Enfermedad Iatrogénica , Internacionalidad , ConsensoRESUMEN
PURPOSE: We aimed to accurately determine ureteral stricture (US) rates following urolithiasis treatments and their related risk factors. METHODS: We conducted a systematic review and meta-analysis following the PRISMA guidelines using databases from inception to November 2023. Studies were deemed eligible for analysis if they included ≥ 18 years old patients with urinary lithiasis (Patients) who were subjected to endoscopic treatment (Intervention) with ureteroscopy (URS), percutaneous nephrolithotomy (PCNL), or shock wave lithotripsy (SWL) (Comparator) to assess the incidence of US (Outcome) in prospective and retrospective studies (Study design). RESULTS: A total of 43 studies were included. The pooled US rate was 1.3% post-SWL and 2.1% post-PCNL. The pooled rate of US post-URS was 1.9% but raised to 2.7% considering the last five years' studies and 4.9% if the stone was impacted. Moreover, the pooled US rate differed if follow-ups were under or over six months. Patients with proximal ureteral stone, preoperative hydronephrosis, intraoperative ureteral perforation, and impacted stones showed higher US risk post-endoscopic intervention with odds ratio of 1.6 (P = 0.05), 2.6 (P = 0.009), 7.1 (P < 0.001), and 7.47 (P = 0.003), respectively. CONCLUSIONS: The overall US rate ranges from 0.3 to 4.9%, with an increasing trend in the last few years. It is influenced by type of treatment, stone location and impaction, preoperative hydronephrosis and intraoperative perforation. Future standardized reporting and prospective and more extended follow-up studies might contribute to a better understanding of US risks related to calculi treatment.
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Litotricia , Complicaciones Posoperatorias , Ureteroscopía , Urolitiasis , Humanos , Ureteroscopía/efectos adversos , Factores de Riesgo , Urolitiasis/cirugía , Urolitiasis/epidemiología , Complicaciones Posoperatorias/epidemiología , Complicaciones Posoperatorias/etiología , Litotricia/efectos adversos , Litotricia/métodos , Constricción Patológica , Nefrolitotomía Percutánea/efectos adversos , Nefrolitotomía Percutánea/métodos , Obstrucción Ureteral/etiología , Obstrucción Ureteral/cirugíaRESUMEN
OBJECTIVE: Current interventional guidelines refer to the cumulative stone diameter to choose the appropriate surgical modality (ureteroscopy [URS], extracorporeal shockwave lithotripsy [ESWL] and percutaneous nephrolithotomy [PCNL]). The stone volume (SV) has been introduced recently, to better estimate the stone burden. This review aimed to summarize the available methods to evaluate the SV and its use in urolithiasis treatment. MATERIAL AND METHODS: A comprehensive review of the literature was performed in December 2022 by searching Embase, Cochrane and Pubmed databases. Articles were considered eligible if they described SV measurement or the stone free rate after different treatment modalities (SWL, URS, PCNL) or spontaneous passage, based on SV measurement. Two reviewers independently assessed the eligibility and the quality of the articles and performed the data extraction. RESULTS: In total, 28 studies were included. All studies used different measurement techniques for stone volume. The automated volume measurement appeared to be more precise than the calculated volume. In vitro studies showed that the automated volume measurement was closer to actual stone volume, with a lower inter-observer variability. Regarding URS, stone volume was found to be more predictive of stone free rates as compared to maximum stone diameter or cumulative diameter for stones >20â¯mm. This was not the case for PCNL and SWL. CONCLUSIONS: Stone volume estimation is feasible, manually or automatically and is likely a better representation of the actual stone burden. While for larger stones treated by retrograde intrarenal surgery, stone volume appears to be a better predictor of SFR, the superiority of stone volume throughout all stone burdens and for all stone treatments, remains to be proven. Automated volume acquisition is more precise and reproducible than calculated volume.
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Cálculos Renales , Litotricia , Nefrolitotomía Percutánea , Urolitiasis , Humanos , Cálculos Renales/cirugía , Litotricia/métodos , Ureteroscopía/métodos , Urolitiasis/terapiaRESUMEN
INTRODUCTION AND OBJECTIVES: As well established flexible ureteroscopy (RIRS). There is still no evidence if gender can have any influence on the outcomes and complication when performing. This study aims to evaluate the role that gender has in performing flexible ureteroscopy from a large series of patients. METHODS: This study retrospectively analyzed patients who underwent RIRS for renal stones from January 2018 to August 2021 within the multicentric FLEXOR registry. Demographics, stone characteristics, perioperative findings, results and complications were analyzed and compared between gender groups. RESULTS: A total of 6669 patients were included, 66.1% were male and 33.9% were female. Stone characteristics was comparable between groups. Female patients had significant higher fever and positive urine culture rates (12% vs. 8% and 37% vs. 34%). Also, females had a slight longer hospital stay (3.8 vs. 3.5 days; Pâ¯<â¯0.001) and more residual fragments after the procedure (23.03% vs. 20.97 (Pâ¯=â¯0.032). Overall complications were slightly significantly higher in women (15.74% vs. 14% (Pâ¯=â¯0.042)) mainly at the expense of fever rates (6.9% vs. 5.7%) whereas the risk of sepsis was similar in both groups. A multivariate analysis showed that larger stone size, multiple and lower pole stones seem to have a negative impact in the incidence of residual stones and complications. CONCLUSION: Our real life global study reflects that female gender may have a correlation with a slightly increased residual fragment rate and overall low grade complications. However, women can safely be treated with RIRS with no increased the rate of sepsis with appropriate care.
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Cálculos Renales , Sepsis , Humanos , Masculino , Femenino , Ureteroscopía/efectos adversos , Ureteroscopía/métodos , Estudios Retrospectivos , Cálculos Renales/cirugía , UreteroscopiosRESUMEN
OBJECTIVE: To determine the relation between ureteral stone impaction and ureteral stricture formation and associated factors. MATERIAL AND METHODS: We retrospectively analyzed the medical records of all patients who underwent endoscopic ureteral stone surgery for impacted ureteral stone at three academic institutions in Turkey, United Kingdom and Spain between June 2019 and January 2022. Examined parameters included patient demographics, stone side, size and localization, time between initiation of symptoms and surgery, type of ureteroscopy (rigid/flexible), presence of nephrostomy or double-J stent prior to URS, intraoperative complications (avulsion/perforation, stone-free status, number of procedures required for stone-free status, postoperative imaging results. RESULTS: A total of 41 patients whom 25 were male and 16 were female, from 3 institutions were included the study. The mean age of the patients was 48.2⯱â¯13.5 years. The median largest diameter of the stones was 9â¯mm (IQR: 8â¯mm). Total 14 (34.1%) patients developed ureteral strictures following ureteroscopy. There was no difference between patients who developed ureteral strictures and patients who did not developed strictures in terms of stone laterality, stone location, hydronephrosis and multiplicity, pâ¯=â¯0.58, pâ¯=â¯0.14, pâ¯=â¯0.79 and pâ¯=â¯0.31. Patients who developed ureteral strictures had a higher rate of preoperative urinary diversion such as nephrostomy or DJS, pâ¯=â¯0.000. CONCLUSION: Interruption of urine passage through ureter via urinary diversion such as nephrostomy or DJS stent prior to ureteral stone surgery might lead ureteral stricture formation in the postoperative period.
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Cálculos Ureterales , Obstrucción Ureteral , Urolitiasis , Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Ureteroscopía/efectos adversos , Ureteroscopía/métodos , Constricción Patológica/etiología , Estudios Retrospectivos , Cálculos Ureterales/cirugía , Cálculos Ureterales/complicaciones , Urolitiasis/cirugía , Urolitiasis/complicaciones , Obstrucción Ureteral/etiologíaRESUMEN
INTRODUCTION: Circumcision is the most common surgical procedure in male children in the world and is performed because of cultural, religious or medical reasons. Traditionally, interrupted sutures are used to close the wound, but 2-Octyl cyanoacrylate (2-OCA) tissue glue can be used as an alternative method to close the circumcision wound. OBJECTIVES: To compare the use of 2-OCA with absorbable sutures in circumcision wound closure in prepubescent patients in terms of operative time, complication rate, postoperative pain and cosmetic results. STUDY DESIGN: We retrospectively evaluated 662 circumcision procedures using sutures and 609 procedures using 2-OCA for wound closure in prepubescent boys. All circumcision procedures were performed by 2 surgeons in a single centre. Operative time was collected from the hospital surgical software system. 62% of the patients in the suture group and 59% of the patients in the 2-OCA group presented for a postoperative check-up 6 weeks after the circumcision. Data regarding postoperative pain, need for analgesia, cosmetic satisfaction and the ease of wound care were collected through questionnaires completed by 25% of the boy's parents in the suture group and 53% of the parents in the 2-OCA group. RESULTS: Mean operative time was significantly shorter in the 2-OCA group (13 min) than in the suture group (17 min). Complications were comparable and mostly minor. Reintervention was only required in 3 cases. According to the parents, the degree of postoperative pain and the postoperative need for analgesics was significantly lower in the 2-OCA group. Wounds closed with 2-OCA were easier to care for. The cosmetic results after 1 day, after 1 week and after 1 month in the 2-OCA group were significantly superior than in the suture group, according to the parents' evaluation. DISCUSSION: The use of 2-OCA in circumcision wound closure has been reported before. Previous studies with mainly limited patient numbers report less pain, shorter procedure times and a higher surgeon satisfaction in terms of cosmetic results. This study is the largest study comparing the use of 2-OCA and interrupted sutures in circumcision wound closure. The retrospective character of the study, the lack of a validated questionnaire tool for the cosmetic evaluation and the use of the parent's evaluation are the limitations of this study. CONCLUSION: The use of 2-OCA in circumcision wound closure results in a shorter operative time, in less postoperative pain, in easy postoperative wound care and in excellent cosmesis when compared to interrupted absorbable sutures. 2-OCA is our current technique of choice in circumcision wound closure.
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Circuncisión Masculina/métodos , Cianoacrilatos/uso terapéutico , Dolor Postoperatorio/prevención & control , Adhesivos Tisulares/uso terapéutico , Preescolar , Circuncisión Masculina/efectos adversos , Humanos , Masculino , Tempo Operativo , Satisfacción del Paciente , Estudios Retrospectivos , Técnicas de Sutura , Suturas , Resultado del TratamientoRESUMEN
The success of radio frequency ablation (RFA) into various surgical fields has fueled the interest of the urological community to study its application in small renal masses (SRM). However, some controversies remain regarding its oncologic efficacy. This paper reviews the effects of technical factors and tumor/tissue characteristics on treatment success, discuss the evaluation of treatment success by post-treatment imaging and histopathology, and highlight intermediate term oncologic outcomes of recent, larger RFA series. The authors have performed a Medline database search regarding the treatment of SRM by RFA from 2003 through August 2010. To evaluate technical factors and tissue characteristics influencing treatment success, and the evaluation of treatment success by imaging and histopathology, papers were selected when they provided detailed descriptions on one or more of these items. For the analysis of oncologic outcomes, the selection was limited to series that treated a minimum of 20 patients or a minimum follow-up of 48 months and reported effectiveness based on follow-up imaging. Technical evolutions and correct patient/tumor selection produced increasingly higher success rates with RFA. Even though tumor skipping has been described in preclinical studies and early clinical trials, this does not seem to influence efficacy of the procedure. Indeed, a 8.7% retreatment rate exists. However, accepting this potential downside, final ablative success rate is 94.1% at intermediate term follow-up. Complications after RFA are less frequent and more often minor compared to surgical series. The present analysis reveals that RFA achieves a high intermediate-term ablative success rate when accepting an 8.7% re-ablation rate. Complication rates are low and usually minor. Based on this data, RFA represents an attractive minimal invasive treatment for SRM, especially in the growing elderly patient population with multiple comorbidities. Long-term follow-up data are expected to confirm the role of RFA in the treatment of SRM.