1.
Bioorg Med Chem
; 25(24): 6404-6411, 2017 12 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-29089258
RESUMEN
Synthesized cyclic perylene diimide, cPDI, showed the binding constant of 6.3â¯×â¯106â¯M-1 with binding number of nâ¯=â¯2 with TA-core as a tetraplex DNA in 50â¯mM Tris-HCl buffer (pHâ¯=â¯7.4) containing 100â¯mM KCl using Schatchard analysis and showed a higher preference for tetraplex DNA than for double stranded DNA with over 103 times. CD spectra showed that TA-core induced its antiparallel conformation upon addition of cPDI in the absence or presence of K+ or Na+ ions. The cPDI inhibits the telomerase activity with IC50 of 0.3⯵M using TRAP assay which is potential anti-cancer drug with low side effect.