The impact of various antiplatelet strategies on the incidence of gouty arthritis in hospitalized patients with acute cerebral infarction.

OBJECTIVES: 1.To explore the incidence of concurrent gouty arthritis (GA) during hospitalization in patients with different subtypes of acute stroke. 2.To investigate disparities in acute cerebral infarction patients with coexisting GA undergoing various antiplatelet strategies. MATERIALS AND METHODS: Data from acute stroke patients admitted to the Affiliated Panyu Central Hospital of Guangzhou Medical University, from January 2019 to December 2021, underwent screening. The incidence of GA in acute stroke patients of various subtypes were analyzed. Subsequently, we divided cerebral infarction cases into three cohorts based on distinct antiplatelet therapies: the aspirin group, the dual antiplatelet therapy group (DAPT，aspirin plus clopidogrel), and the clopidogrel group. Investigate disparities in acute cerebral infarction patients with coexisting GA undergoing various antiplatelet strategies. RESULTS: A total of 12,381 patients with acute stroke were screened in this study. The incidence of GA in various subtypes of acute stroke was as follows: cerebral infarction (3.56 %, n = 9890), TIA (1.81 %, n = 443), cerebral hemorrhag (0.64 %, n = 1713), and SAH (0.30 %, n = 335). The incidence of GA in patients with ischemic stroke is higher than that of hemorrhagic stroke (χ2 = 49.258, p<0.001). No significant differences were observed in the incidence of GA among three different antiplatelet therapy groups. But there was marginal statistical difference in the incidence of GA between the aspirin group and the DAPT group (P = 0.051), as well as between the clopidogrel group and the DAPT group (P = 0.059). CONCLUSIONS: The incidence of GA in patients with ischemic stroke is higher than that of hemorrhagic stroke. No significant differences were observed in the incidence of GA in acute cerebral infarction across various antiplatelet Strategies. The marginal statistical difference in the incidence of GA between the single antiplatelet group and the DAPT group requires further investigation.

Genomic Insights into the First Emergence of blaNDM-5-Carrying Carbapenem-Resistant Salmonella enterica Serovar London Strain in China.

Carbapenem-resistant Salmonella enterica (S. enterica) pose a significant threat to public health, causing gastroenteritis and invasive infections. We report the first emergence of a carbapenem-resistant S. enterica serovar London strain, A132, carrying the blaNDM-5 gene in China. Whole-genome sequencing and bioinformatics analysis assigned A132 to be ST155, a multidrug-resistant clone frequently reported in China. The strain A132 exhibited resistance to multiple antibiotics, with 20 acquired antibiotic resistance genes (ARGs) identified, predominantly located on the IncFIB plasmid (pA132-1-NDM). Notably, the blaNDM-5 gene was located within an IS26 flanked-class 1 integron-ISCR1 complex, comprising two genetic cassettes. One cassette is the class 1 integron, which may facilitate the transmission of the entire complex, while the other is the blaNDM-5-containing ISCR1-IS26-flanked cassette, carrying multiple other ARGs. Genbank database search based on the blaNDM-5-carrying cassette identified a similar genetic context found in transmissible IncFIA plasmids from Escherichia coli (p91) and Enterobacter hormaechei (p388) with a shared host range, suggesting the potential for cross-species transmission of blaNDM-5. To our knowledge, this is the first reported case of Salmonella serovar London ST155 harboring blaNDM-5 gene. Phylogenetic analysis indicated a close relationship between A132 and eight S. London ST155 strains isolated from the same province. However, A132 differed by carrying the blaNDM-5 gene and four unique ARGs. Given the high transmissibility of the F-type plasmid harboring blaNDM-5 and 18 other ARGs, it is imperative to implement vigilant surveillance and adopt appropriate infection control measures to mitigate the threat to public health.

Urolithin A Prevents Sleep-deprivation-induced Neuroinflammation and Mitochondrial Dysfunction in Young and Aged Mice.

Sleep deprivation (SD) has reached epidemic proportions worldwide and negatively affects people of all ages. Cognitive impairment induced by SD involves neuroinflammation and mitochondrial dysfunction, but the underlying mechanisms are largely unknown. Urolithin A (UA) is a natural compound that can reduce neuroinflammation and improve mitochondrial health, but its therapeutic effects in a SD model have not yet been studied. Young (3-months old) and aged (12-months old) mice were sleep deprived for 24 h, and UA (2.5 mg/kg or 10 mg/kg) was injected intraperitoneally for 7 consecutive days before the SD period. Immunofluorescent staining, western blotting, and RT-PCR were employed to evaluate levels of proteins involved in neuroinflammation and mitochondrial function. Transmission electron microscope and Golgi-Cox staining were used to evaluate mitochondrial and neuronal morphology, respectively. Finally, contextual fear conditioning and the Morris water maze test were conducted to assess hippocampal learning and memory. In the hippocampus of young (3 months-old) and aged (12 months-old) mice subjected to 24 h SD, pretreatment with UA prevented the activation of microglia and astrocytes, NF-κB-NLRP3 signaling and IL-1ß, IL6, TNF-α cytokine production, thus ameliorating neuroinflammation. Furthermore, UA also attenuated SD-induced mitochondrial dysfunction, normalized autophagy and mitophagy and protected hippocampal neuronal morphology. Finally, UA prevented SD-induced hippocampal memory impairment. Cumulatively, the results show that UA imparts cognitive protection by reducing neuroinflammation and enhancing mitochondrial function in SD mice. This suggests that UA shows promise as a therapeutic for the treatment of SD-induced neurological disorders.

Influence Mechanisms of Community Sports Parks to Enhance Social Interaction: A Bayesian Belief Network Analysis.

Urban green spaces provide multiple ecosystem services to improve human health and well-being. Cultural ecosystem services (CES) are recognized as the most important services for urban residents through the key of social interaction. Researchers commonly acknowledge the function of community sports parks to enhance social interaction. Nevertheless, existing studies generally do not pay enough attention to the influence mechanisms of community sports parks and social interaction, especially the different types of spaces in community sports parks, which could be due to the complex feature of social interaction. This paper selects three community sports parks in Chongqing as the case study, uses BBN to identify the influence mechanisms of three common types of spaces (fitness equipment space, path space, and sports court space) in community sports parks and social interaction, aiming to explore how community sports parks enhance social interaction. The results indicated that sports court space such as basketball court and badminton court enhanced social interaction best; however, the spaces farther away from the park entrances were generally less effective in enhancing interaction. All these three types of sports spaces showed the influence mechanism of "Spatial Factors-Activity Type-Social Interaction", while differences existed in the specific spatial influencing factors. The findings highlight that based on the BBN obtained in this study, the threshold range of spatial factors could be adjusted to enhance the effect of community sports parks on social interaction.

Building a New Framework for Urban Parking Facilities Research with Quality Improvement: The Case of Chongqing, China.

People-oriented development has become the main theme of China's current social development, and the construction of various urban infrastructure has shifted from a focus on functionalism to a continuous pursuit of service quality. As an essential infrastructure for urban transport, urban parking facilities have an impact on pedestrian experience and landscape appearance based on the provision of parking functions. Therefore, this study is oriented to improving the quality of parking facilities, proposes a research framework of parking facilities based on meeting functional demand and service quality, and constructs a quality index to evaluate the quality of parking facilities, which includes three dimensions of evaluation indexes: pedestrian space impact, environmental space impact, and demand matching. By analyzing the current characteristics of urban parking facilities and measuring their quality index (6.5), the study finds that while satisfying the basic function of parking demand, it brings a negative impact on the pedestrian experience and the overall urban landscape appearance of the city. Motivated by this, this study proposes strategies to improve the quality of parking facilities: demand matching, spatial synergy, and environmental design to address parking difficulties, while injecting different ideas for future value orientation of parking facility planning and construction.

Effects and Environmental Features of Mountainous Urban Greenways (MUGs) on Physical Activity.

The role played by urban greenways in supporting physical activity (PA) for public health benefits has been receiving increasing attention. Most studies on this topic have been conducted in plains, whereas studies in mountainous regions have been limited as a result of the complexity of these areas. To address this knowledge gap, this article aims to analyze the effects of the environmental features for a mountainous urban greenway (MUG) on PA, leading to better support for greenway practice in mountainous areas. A volunteered geographic information (VGI) method was applied through the mobile app KEEP to collect 1314 valid records of PA including its density (total PA distance per unit area within the buffer zone) and attributes (distance, duration and speed) in the Yuzhong Peninsula, Chongqing, China. Similar to those of the studies conducted in the plains, our results showed that PA density was affected by the MUG and its surrounding environment. The key environmental features included residential density, open-space POI, the slope, the transportation-MUG (T-MUG) ratio and the recreational-MUG (R-MUG) ratio. For the PA attributes, the MUG showed stronger effects than the surrounding environment. The key environmental features included the slope and type of MUG, of which the former was negatively associated with distance and speed. The T-MUG ratio was positively related to duration and speed, while the R-MUG ratio was positively related to duration and distance. No association was found between livelihood (L-MUG) and PA. Hence, to support both the PA density and attributes, the environmental qualities for recreation and the types of R-MUGs should be given more consideration in practice.

To Create a Safe and Healthy Place for Children: The Associations of Green Open Space Characteristics With Children's Use.

Green open space (GOS) is an important outdoor resource for the well-being of children by providing places for physical activity (PA), especially in the highly urbanized environment. The COVID-19 lockdowns have made children have more sedentary time than before due to less access to public places. This article aims to examine the associations of GOS characteristics (environmental and surrounding) and children's use (visitation and PA pattern) to provide evidence for promoting their PA during the pandemic. This study employed the method of GPS positioner, accelerometer, and survey to measure the children's actual use in GOS. A total of 179 children participated in the study and 10 GOSs were selected. The children were provided with the accelerometers and GPS positioners to track their walking steps, duration, and locations. The environmental characteristics and 1 km buffer of the selected GOSs were explored as extended study area. Results showed that 49.16% of children reported more visitations than before the pandemic, and 48.60% of them preferred to go on weekdays during the pandemic. Both environmental and surrounding characteristics could affect the visitation pattern. The size (p < 0.000), residential ratio (p < 0.000), and intersection density (p < 0.000) were found as the factors significantly associated with visitation pattern. The children's PA pattern was mainly associated with the environmental characteristics of size (p < 0.000), sports, and playground proportion (p < 0.000). The locations of children's PA were mainly around square, playground, sheltered place, and waterside areas. COVID-19 has transformed the children's use of GOS, as well as their relationship with GOS. The large GOS was more likely to promote PA and its use by the children. The environmental and surrounding characteristics of GOS could affect their use pattern, whereas their PA pattern was mainly associated with the environmental characteristics. The findings suggest that GOS characteristics could be an effective solution to respond the challenge from the pandemic, and promote their visitation and PA.

The Study on Spatial Elements of Health-Supportive Environment in Residential Streets Promoting Residents' Walking Trips.

Residents' walking trips are a kind of natural motion that promotes health and wellbeing by modifying individual behavior. The purpose of this study was to evaluate the major influence of the spatial elements of a health-supportive environment on residents' walking trips. This study analyzes residents' walking trips' elements based on the spatiotemporal characteristics of walking trips, as well as the spatial elements of a health-supportive environment in residential streets based on residential health needs. To obtain the spatial elements that promote residents' walking trips and to build an ordered logistic regression model, two methods-a correlation analysis and a logistic regression analysis-were applied to analyze the elements of residents' walking trips as well as the spatial elements of a health-supportive environment in residential streets by means of SPSS software, using on-site survey results of ten residential streets and 2738 pieces of research data. The research showed that the nine kinds of spatial elements that significantly affect residents' walking trips are density of pedestrian access, density of bus routes, near-line rate of roadside buildings, average pedestrian access distance, square area within a 500 m walking distance, distance to the nearest garden, green shade ratio, density of street intersections, and the mixed proportion of differently aged residential buildings. In order to construct a spatial environment that promotes walking trips, it is necessary to improve the convenience of residents' walking trips, to increase the safety of roadside buildings and pedestrian access, to expand the comfort of "getting out to the nature", and to enrich the diversity of different architectural styles and street density.

[Moxibustion therapy is superior to manual acupuncture in the treatment of perimenopausal insomnia: a randomized controlled trial].

OBJECTIVE: To compare the clinical effect of manual acupuncture and moxibustion therapies in the treatment of perimenopausal insomnia (PMI). METHODS: A total of 60 outpatients with PMI were randomly and equally divided into an acupuncture group (29 cases) and a moxibustion group (28 cases). Acupoints Zhongwan (CV12), Xiawan (CV10), Qihai (CV6) and Guanyuan (CV4) were employed in these two groups. For acupuncture group, filiform needles were inserted slowly into these acupoints and twirled mildly for a while, and then retained for 30 min. When moxibustion performed, the ignited moxa-cone was applied to the same 4 acupoints, with 7 cones for each acupoint. The treatment was conducted once daily for 10 consecutive days, suspended for 2 days, then another 10 days' treatment followed. The Pittsburgh Sleep Quality Index (PSQI) scale (7 items: subjective sleep quality, sleep latency, duration of sleep, habitual sleep efficiency, sleep disturbance, use of sleeping medications, and daytime dysfunction, 0－3 points per item, 0－21 points in total) was used to evaluate the patient's sleep quality. The clinical therapeutic effect was also assessed according to the sleep rate (＝sleep duration/total duration from spin-in to wake-up×100%). The contents of serum follicular stimulating hormone (FSH), estradiol (E2) and luteinizing hormone (LH) were detected using radioimmunoassay. RESULTS: After treatment, the total score of PSQI and the score of each item were all significantly reduced in the two groups relevant to their own pre-treatment (P<0.01). The scores of sleep latency, sleep disturbance and daytime dysfunction were comparable between the two groups (P>0.05), but the total score, and scores of sleep quality, sleep duration, sleep efficiency, and use of sleeping medication were significantly lower in the moxibustion group than in the acupuncture group (P<0.05). Of the 29 and 28 cases in the acupuncture and moxibustion groups, 6 (20.69%) and 11 (39.29%) were cured, 7 (24.14%) and 9 (32.14%) experienced marked improvement, 9(31.03%) and 5 (17.86%) were effective, and 7(24.14%) and 3 (10.71%) ineffective, with the total effective rate being 75.86% and 89.29%, respectively. The therapeutic effect of moxibustion was obviously superior to that of acupuncture treatment (P<0.05). After the treatment, the levels of serum FSH and LH were significantly decreased (P<0.01), and that of E2 was significantly increased in both groups (P<0.01). The levels of FSH and E2 in the moxibustion group were obviously improved than those of the acupuncture group (P<0.05). CONCLUSION: Both acupuncture and moxibustion can relieve the sleep quality of patients with PMI, which may be associated with their effect in regulating serum hormone levels. The therapeutic effect of moxibustion is superior to that of acupuncture.

Identifying Key Drivers of Return Reversal with Dynamical Bayesian Factor Graph.

In the stock market, return reversal occurs when investors sell overbought stocks and buy oversold stocks, reversing the stocks' price trends. In this paper, we develop a new method to identify key drivers of return reversal by incorporating a comprehensive set of factors derived from different economic theories into one unified dynamical Bayesian factor graph. We then use the model to depict factor relationships and their dynamics, from which we make some interesting discoveries about the mechanism behind return reversals. Through extensive experiments on the US stock market, we conclude that among the various factors, the liquidity factors consistently emerge as key drivers of return reversal, which is in support of the theory of liquidity effect. Specifically, we find that stocks with high turnover rates or high Amihud illiquidity measures have a greater probability of experiencing return reversals. Apart from the consistent drivers, we find other drivers of return reversal that generally change from year to year, and they serve as important characteristics for evaluating the trends of stock returns. Besides, we also identify some seldom discussed yet enlightening inter-factor relationships, one of which shows that stocks in Finance and Insurance industry are more likely to have high Amihud illiquidity measures in comparison with those in other industries. These conclusions are robust for return reversals under different thresholds.

The history, hotspots, and trends of electrocardiogram.

The electrocardiogram (ECG) has broad applications in clinical diagnosis and prognosis of cardiovascular disease. Many researchers have contributed to its progressive development. To commemorate those pioneers, and to better study and promote the use of ECG, we reviewed and present here a systematic introduction about the history, hotspots, and trends of ECG. In the historical part, information including the invention, improvement, and extensive applications of ECG, such as in long QT syndrome (LQTS), angina, and myocardial infarction (MI), are chronologically presented. New technologies and applications from the 1990s are also introduced. In the second part, we use the bibliometric analysis method to analyze the hotspots in the field of ECG-related research. By using total citations and year-specific total citations as our main criteria, four key hotspots in ECG-related research were identified from 11 articles, including atrial fibrillation, LQTS, angina and MI, and heart rate variability. Recent studies in those four areas are also reported. In the final part, we discuss the future trends concerning ECG-related research. The authors believe that improvement of the ECG instrumentation, big data mining for ECG, and the accuracy of diagnosis and application will be areas of continuous concern.

The highly-cited Electrocardiogram-related articles in science citation index expanded: characteristics and hotspots.

We used bibliometric analysis methodology in the expanded Science Citation Index to identify highly-cited electrocardiogram (ECG)-related articles with total citations (TC2012) exceeding 100 from the publication year to 2012. Web of Science search tools were used to identify the highly-cited articles. The aspects analyzed for highly cited publications included effect of time on citation analysis, journals and Web of Science categories, number of authors per publication, originating institutions and countries, total citation and total citation per year life cycles of articles (C2012) and research hotspots. Results showed that a total of 467 electrocardiogram-related publications were regarded as the highly-cited publications. TC2012 ranged from 101 to 2879, with 215 as the average number of citations. No highly-cited publications have emerged yet during the first two years of the present 2010 Decade. All 11 countries and institutions originating highly-cited ECG-related publications were developed countries, USA in 9 of them. Four subject categories were identified as hotspots by total citations TC2012 and C2012: atrial fibrillation, long QT syndrome, angina and myocardial infarction, and risk factor analysis and health evaluation.