A Deep Learning Filter that Blocks Phishing Campaigns Using Intelligent English Text Recognition Methods.

Most of the sophisticated attacks in the modern age of cybercrime are based, among other things, on specialized phishing campaigns. A challenge in identifying phishing campaigns is defining a classification of patterns that can be generalized and used in different areas and campaigns of a different nature. Although efforts have been made to establish a general labeling scheme in their classification, there is still limited data labeled in such a format. The usual approaches are based on feature engineering to correctly identify phishing campaigns, exporting lexical, syntactic, and semantic features, e.g., previous phrases. In this context, the most recent approaches have taken advantage of modern neural network architectures to record hidden information at the phrase and text levels, e.g., Long Short-Term Memory (LSTM) and Convolutional Neural Networks (CNNs). However, these models lose semantic information related to the specific problem, resulting in a variation in their performance, depending on the different data sets and the corresponding standards used for labeling. In this paper, we propose to extend word embeddings with word vectors that indicate the semantic similarity of each word with each phishing campaigns template tag. These embedded keywords are calculated based on semantic subfields corresponding to each phishing campaign tag, constructed based on the automatic extraction of keywords representing these tags. Combining general word integrations with vectors is calculated based on word similarity using a set of sequential Kalman filters, which can then power any neural architecture such as LSTM or CNN to predict each phishing campaign. Our experiments use a data indicator to evaluate our approach and achieve remarkable results that reinforce the state-of-the-art.

Cyclo(RGD) peptide-decorated silver nanoparticles with anti-platelet potential for active platelet-rich thrombus targeting.

The development of integrated nanomedicine for prevention and early diagnosis of thrombosis is highly significant. Platelet plays a vital role in thrombotic disorders, offering an ideal target for thromboprophylaxis and imaging of thrombi. We herein fabricated cyclo(RGD) peptide-decorated AgNPs (designated cRGD-AgNPs) for active targeting platelet-rich thrombi. In vitro cytotoxicity and hemolysis assays demonstrated that cRGD-AgNPs have acceptable biocompatibility pattern. Both PEG-AgNPs (non-targeted version) and cRGD-AgNPs can inhibit agonist-mediated platelet aggregation, whereas the latter exhibited significant attenuation on platelet activation and adhesion onto collagen and fibrinogen matrix. Furthermore, the superior binding ability of cRGD-AgNPs with platelet-rich thrombus was demonstrated in static/dynamic condition in vitro. In vivo studies revealed that cRGD-AgNPs could actively target thrombi in a mouse model of carotid artery thrombi with favorable safety. Our results here suggest that cRGD-AgNPs with intrinsic anti-platelet potential might be promising nano theranostics for thromboprophylaxis and active thrombus targeting.

Comparative Study on Viscoelastic Evaluation Methods of Polymer Materials Based on Ultrasonic Method.

Rubber, as a kind of macromolecular material often used in large ships, aviation, aerospace, and other fields, has remarkable viscoelasticity at room temperature. Therefore, it is of great significance to evaluate the viscoelastic properties of polymer composites. In this paper, four kinds of rubber materials are taken as research objects. Based on the principle of ultrasonic detection, the viscoelastic evaluation of the sample materials is carried out through experiments and simulations. On the basis of previous research, the surface reflection method (SRM) and the bottom reflection method (BRM) are compared in depth. First, the spectrum of received signals is analyzed, and the storage elastic modulus, loss elastic modulus, attenuation coefficient and loss tangent value are obtained. Secondly, the results of the BRM and the SRM are compared and analyzed in the frequency domain of -6 dB. The results show that both the SRM and BRM are feasible in the evaluation of the viscoelasticity of the material, and the variation trends observed for the above-mentioned parameters in the effective frequency domain are consistent, especially at the center frequency. Finally, aiming at the mode transformation of the acoustic wave around the ultrasonic sensor, the practical performance of the surface reflection method is optimized by increasing the diameter of the ultrasonic sensor.

Endoscopic biliary drainage management for children with serious cholangitis caused by congenital biliary dilatation.

Congenital biliary dilatation (CBD) is usually associated with complications such as recurrent cholangitis, manifested as abdominal pain, vomiting, and jaundice. If cholangitis cannot be controlled by conservative treatment, a good therapeutic effect can be obtained through percutaneous biliary drainage or open T-tube drainage. We aimed to evaluate our experiences in biliary drainage through endoscopic retrograde cholangiopancreatography in children with cholangitis caused by CBD. From January 2014 to December 2017, 167 children with CBD were treated in our hospital. 17 patients (10.18%) with serious cholangitis caused by CBD underwent ERCP. There were 4 males and 13 females with an age range of 10-120 months (average 56.4 months). Placement of a biliary stent was attempted for biliary drainage through endoscopic retrograde cholangiopancreatography. Of the 17 patients studied, 13 children had jaundice and 15 had elevated aminotransferases. ERCP showed CBD in all patients and a common biliopancreatic duct in 12 of 17 patients (70.6%). Five patients underwent nasobiliary drainage and 12 patients underwent biliary drainage through double pigtail tubes. All patients achieved successful biliary drainage. Postoperative pancreatitis occurred in one patient. Biochemical indicators decreased significantly in 12 patients (70.6%) on the second postoperative day. The average length of hospital stay after surgery was 4.5 (range 3-7) days. No major complications related to ERCP were observed and all children had a good prognosis so far. Endoscopic biliary drainage is a safe, simple, and reliable technique. It can be used to resolve CBD-associated cholangitis, evaluate the biliary tract and pancreatobiliary duct junction, and guide pediatric surgeons to choose the right time and the correct procedure for CBD.

[Construction and primary application of oligonucleotide microarray specialized for pancreatic adenocarcinoma-associated genes].

OBJECTIVE: To investigate the construction of oligonucleotide microarray specialized for pancreatic adenocarcinoma-associated genes and its application. METHODS: Pancreatic cancer related genes were purposely selected, and oligonucleotide microarray was prepared by spotting oligonucleotide probes onto glass slides coated with APS-PDC. Total RNA were extracted from frozen tissues with TRIzol method according to the manufacturer's protocol, and purified with QIAGEN RNeasy Kit. Labeled cDNA targets for hybridizations were synthesized by reverse transcription from control- and cancer-total RNA samples in the presence of Cy5-dCTP and Cy3-dCTP, respectively. The labeled probes were hybridized with oligonucleotide microarray for 16 h to 18 h. Hybridized microarray was scanned by Agilent laser scanner, and the acquired image was analyzed by Imagene3.0 software. The intensity ratio of Cy3 and Cy5 were calculated. To confirm the expression profiles of these genes, quantitative reverse transcription-PCR (Q RT-PCR) was carried out with CDC25B and TUSC3 genes. The product of PCR were quantitated by comparative Ct method. RESULTS: The signal of microarray hybridization was clear, and the images had a lower background and higher signal-noise ratio. The signal of positive control spots were uniform, and spots of negative control and blank signal were fairly low. In comparison with normal pancreas, 24 differential expressed genes were identified, which included 17 up-regulated and 7 down-regulated genes. The results of Q RT-PCR demonstrated that the expression of CDC25B and TUSC3 in pancreatic cancer were increased and decreased respectively, which consistent with microarray hybridization. CONCLUSIONS: The oligonucleotide microarray specialized for pancreatic cancer are desirable for its specialty, flexibility and sensitivity, which can simultaneously and parallelly detect multiple pancreatic cancer-associated genes. In contrast to normal pancreatic tissues, the genes expression profile are different significantly in pancreatic cancer.