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1.
Sci Total Environ ; 928: 172198, 2024 Jun 10.
Artículo en Inglés | MEDLINE | ID: mdl-38580114

RESUMEN

Pedestrian spaces adjacent to arterial roads are characterized by the dominance of traffic noise alongside various human activities. Research on the impact of traffic noise on the soundscape evaluation of pedestrian spaces has not considered human activities spatial contexts. To address this research gap, the present study constructed auditory environments for pedestrian spaces in the contexts of commuting, residential, and commercial activities. A total of seven auditory environments were subjected to laboratory auditory evaluations, including perceived dominance of sound source, acoustic comfort, and perceived affective quality of the soundscape. The results indicated that in pedestrian spaces with constant traffic noise, the presence of significant human activity sounds led to a decreased perceived dominance of traffic noise and an increased acoustic comfort, despite the higher acoustic energy. Thus, pedestrian spaces with a variety of human activity received better soundscape evaluations. The elements that reflected the human activities spatial contexts, including the types and intensity of human activities, played a crucial role in soundscape evaluations. Better acoustic comfort was reported in pedestrian spaces characterized by low-intensity residential activities and high-intensity commercial activities. Additionally, pedestrian spaces with more intense activities offered an actively engaging soundscape. The findings can provide reference for a more accurate evaluation of the soundscape in pedestrian spaces and guide the soundscape design of pedestrian environments.


Asunto(s)
Ruido del Transporte , Peatones , Humanos , Actividades Humanas , Adulto , Acústica , Sonido
2.
Front Psychol ; 12: 707477, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34335421

RESUMEN

In communities, outdoor activity space is utilized most often by older adults and children, and the soundscape is very important for its quality. For different community planning modes, such as gated and open communities, focus should be on different soundscape enhancement strategies for outdoor spaces. In this paper, typical samples of activity spaces in a gated community and in an open community were used. The comparison was conducted through soundscape evaluation including an analysis of the dominance of various sound sources, noise annoyance, and the perceptual dimensions of soundscape. The results showed that noise annoyance in the gated community was significantly lower than in the open community, although the noise level was of no significance between the two communities. The community planning mode moderated the relationships among the soundscape perception parameters between the gated and open communities. To reduce noise annoyance in the gated communities, each sound source should be considered; in open communities, traffic noise only should be considered. In a gated community, adding natural sounds to reduce noise annoyance may be a feasible intervention; in an open community, this is not necessary. Besides, there was no relationship between noise annoyance and Eventfulness in an open community, indicating that noise annoyance was insufficient to explain the complex sound environment of the community. China's community planning will gradually shift from a gated community to an open community, making the soundscape of outdoor activity spaces likely to change dramatically in the future. The findings will help urban designers and managers to adopt targeted strategies to improve the soundscape and quality of life of community-dwelling older adults and children.

3.
Mar Drugs ; 16(11)2018 Oct 23.
Artículo en Inglés | MEDLINE | ID: mdl-30360574

RESUMEN

Five new acylated aminooligosaccharides (1⁻5), together with one known related analogue (6), were isolated from Streptomyces sp. HO1518. Their structure was identified by extensive spectroscopic analysis, including 1D and 2D NMR data and high resolution electrospray ionization mass spectrometry (HRESIMS), and by comparison with those reported in the literature. All of the new compounds showed more promising porcine pancreatic α-amylase (PPA) inhibitory activities than the clinical drug acarbose, indicating them as potential pharmaceutical drug leads toward type II diabetes.


Asunto(s)
Inhibidores de Glicósido Hidrolasas/química , Inhibidores de Glicósido Hidrolasas/farmacología , Oligosacáridos/química , Oligosacáridos/farmacología , alfa-Amilasas Pancreáticas/antagonistas & inhibidores , Streptomyces/química , Animales , Secuencia de Carbohidratos , Proliferación Celular/efectos de los fármacos , Inhibidores de Glicósido Hidrolasas/aislamiento & purificación , Oligosacáridos/aislamiento & purificación , Porcinos
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