Exploring the correlation and causation between alpha oscillations and one-second time perception through EEG and tACS.

Alpha oscillations have been implicated in time perception, yet a consensus on their precise role remains elusive. This study directly investigates this relationship by examining the impact of alpha oscillations on time perception. Resting-state EEG recordings were used to extract peak alpha frequency (PAF) and peak alpha power (PAP) characteristics. Participants then performed a time generalization task under transcranial alternating current stimulation (tACS) at frequencies of PAF-2, PAF, and PAF+2, as well as a sham condition. Results revealed a significant correlation between PAP and accuracy, and between PAF and precision of one-second time perception in the sham condition. This suggests that alpha oscillations may influence one-second time perception by modulating their frequency and power. Interestingly, these correlations weakened with real tACS stimulations, particularly at higher frequencies. A second analysis aimed to establish a causal relationship between alpha peak modulation by tACS and time perception using repeated measures ANOVAs, but no significant effect was observed. Results were interpreted according to the state-dependent networks and internal clock model.

Comparison of systemic lupus erythematosus patients and healthy individuals in terms of autobiographical memory, mood, and cognitive emotion regulation.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown cause. It affects different organs in the body. Neuropsychiatric manifestations are among the adverse effects of this disease. Considering the importance of neuropsychiatric manifestations, especially memory dysfunction and mood disorders, early neuropsychological evaluation and serious rehabilitation programs are needed. The present study aimed to compare SLE patients and healthy individuals in terms of autobiographical memory, mood, and cognitive emotion regulation. A sample of 30 SLE patients and 30 healthy individuals was selected by the convenience sampling method. The sample was evaluated by tests such as the Autobiographical Memory Test, the Beck Depression Inventory-second edition, and the Cognitive Emotion Regulation Questionnaire. The data were analyzed by the univariate analysis of variance, multivariate analysis of variance, and the Mann-Whitney U tests. The results of the study revealed a significant difference (p < .01) between SLE patients and healthy individuals in terms of autobiographical memory functioning in retrieving past memories and delay in retrieving memories. A significant difference (p < .001) was also found between SLE patients and healthy individuals in terms of mood. However, no significant difference was observed in terms of cognitive emotion regulation. Based on the results of this study, SLE patients' memory, especially autobiographical memory, and their mood are adversely affected by the disease-related neurological damage.

A brief clinical report documenting a novel therapeutic technique (MEmory Specificity Training, MEST) for depression: a summary of two pilot randomized controlled trials.

BACKGROUND: Depression has a profound effect on quality of life (QoL) and is associated with rumination, hopelessness and social difficulties. It is important to explore novel intervention techniques that may reduce depression, and also improve rumination, hope and QoL. AIMS: In this brief clinical report, we report the findings of two pilot randomized controlled trials examining the feasibility of a potentially important novel clinical technique (MEmory Specificity Training, MEST) on depression, social problem-solving (Study 1), rumination, hope and QoL (Study 2). METHOD: In Study 1, Iranian women with depression (n = 24) completed the Beck Depression Inventory-II and Means-Ends Problem-Solving test at baseline, post-training and 2-month follow-up. In Study 2, female students with moderate depression (n = 24) completed the Ruminative Response Scale, Adult Hope Scale and Short-Form Health Survey at baseline and post-training. Assessors were blind to group allocation. In both studies participants were randomly assigned to MEST or a non-active control group. RESULTS: In both studies, MEST was found to be feasible and associated with low drop-out rates and high rates of self-reported patient and group facilitator satisfaction. There was preliminary evidence that MEST may bring about clinical benefit in terms of depression, social problem-solving (Study 1), QoL, rumination and hope (Study 2). CONCLUSIONS: MEST is a promising technique in the treatment of depression.

Comparison of Cognitive Rehabilitation versus Donepezil Therapy on Memory Performance, Attention, Quality of Life, and Depression among Multiple Sclerosis Patients.

BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that affects cognitive performance and leads to depression and decreased quality of life (QOL). The current study aims to assess the effects of cognitive rehabilitation versus donepezil therapy on memory, attention, depression, and QOL in MS patients compared to placebo and control groups. METHODS: Eighty MS patients were randomly selected from parallel randomized trials and divided into four groups: A: cognitive rehabilitation (10 sessions of 120 minutes), B: control (no intervention), C: donepezil (10 mg daily), and D: placebo. Patients received the intervention for three months. They were assessed for cognitive status, depression, and QOL prior to the intervention and immediately after that using abbreviated mental test (AMT), prospective and retrospective memory questionnaire (PRMQ), everyday memory questionnaire (EMQ), digit span, MSQOL-54, and second edition Beck depression inventory (BDI). We compared scores between groups after the intervention, as well as the progression of scores in every single group. RESULT: s. The cognitive rehabilitation group showed improvement in EMQ, RPMQ, digit span, physical and mental health subscales of MSQOL54, and depression (P < 0.05). We observed the same effect for donepezil except for the digit span test (P = 0.15). Intergroup comparison of scores showed the superiority of cognitive rehabilitation over donepezil in digit span, depression, and mental health scores. CONCLUSION: Both donepezil and cognitive rehabilitation effectively improve memory performance, attention, depression, and QOL in MS patients. Cognitive rehabilitation is superior altogether. This study is registered with the Iranian registry of clinical trials http://clinicaltrials.gov/ct2/show/IRCT2016042227522N1.

Effect of Donepezil on Cognitive Impairment, Quality of Life, and Depression in Multiple Sclerosis Patients: A Randomized Clinical Trial.

BACKGROUND: Cognitive impairment is one of the debilitating consequences of multiple sclerosis (MS) with negative effects on daily life, individual and social activities, quality of life (QOL), and depression. No approved medication is introduced so far for affected individuals. We aimed to evaluate the efficacy of donepezil on cognitive performance, QOL, and depression in MS. METHODS: This is a double-blinded randomized clinical trial conducted on 100 patients with MS during 2018. Patients were assessed prior to intervention abbreviated mental test (AMT), prospective and retrospective mental questionnaire (PRMQ), everyday memory questionnaire (EMQ), digit span test, Beck depression inventory (BDI), and MSQOL questionnaire. Then patients were randomly divided into two groups of treatment (daily regimen of 10 mg donepezil) and placebo for 3 months. Subjects were reassessed using the same instruments at the end of intervention. RESULTS: Fifty patients remained in each group at the end of study. The mean age in donepezil and placebo groups was 31.9 ± 5.89 and 30.65 ± 5.43 years, respectively. EMQ, PRMQ, digit span test, MSQOL, and depression scores improved following donepezil therapy (P < 0.001) while no statistically significant difference was found in the placebo group (P > 0.05). Comparison of two groups also showed more favorable scores in donepezil group with respect to all assessment tools (P < 0.001). CONCLUSIONS: Donepezil could effectively improve cognitive impairment in MS patients. Also, its positive effect on QOL and depression could result in a smaller number of interventions in this group of patients.

Evaluation of cognitive rehabilitation on the cognitive performance in multiple sclerosis: A randomized controlled trial.

BACKGROUND: Multiple sclerosis (MS) can involve cognitive entities, including memory, attention, performance, and information processing. Furthermore, MS causes depression and negatively affects the quality of life (QOL). This study was aimed to assess the efficacy of cognitive rehabilitation on cognitive entities of MS patients. MATERIALS AND METHODS: This is a clinical trial study conducted on 56 MS patients in 2016-2017. Patients were randomly divided into two Groups of A (cognitive rehabilitation) and B (control group). Patients were evaluated in terms of memory, attention, QOL, and depression. Questionnaires included Abbreviated Mental Test, Prospective and Retrospective Memory Questionnaire, Everyday Memory Questionnaire, Digit Spam test for attention assessment, QOL-54 questionnaire, and Second version of Beck questionnaire assessing depression. They were filled through an interview before the study initiation, and then, the intervention group underwent ten sessions of cognitive rehabilitation and questionnaires refilled within 3 months after study initiation. Outcomes of the two groups were compared. RESULTS: Memory, attention, QOL, and depression improved significantly following the intervention in cases (P < 0.05), while no significant change was observed among controls (P > 0.05). Comparison of cases and controls in the second evaluation showed a significant difference between cases and controls (P < 0.05). CONCLUSION: Ten sessions of cognitive rehabilitation could significantly improve MS patients' cognitive performance. Moreover, this approach affected their QOL and sense of depression in a decisive trend. It can be concluded that cognitive rehabilitation can successfully affect numerous aspects of MS patients, while numerous medical therapies may be required for treatment of each mere aspect. Further evaluations are strongly recommended.

Memory specificity training can improve working and prospective memory in amnestic mild cognitive impairment.

Amnestic Mild Cognitive Impairment (MCI) is one of the cognitive profiles of aging. OBJECTIVE: In this study, Memory Specificity Training (MEST) was used as cognitive training in patients with amnestic MCI to understand the effectiveness of the intervention on memory dimensions. METHODS: Twenty patients that met the criteria for amnestic MCI were selected and randomly assigned to experimental (n=10) or control (n=10) groups. The experimental group received five sessions of training on memory specificity while the participants in the control group took part in two general placebo sessions. Participants were assessed before, immediately after, and three months after, the treatment using the Autobiographical Memory Test, the Prospective and Retrospective Memory Questionnaire, the Wechsler Memory Scale, and the Hospital Anxiety and Depression Scale. Analysis of variance was used to analyze the data. RESULTS: Results from both post-test and follow-up treatment indicated that MEST improves working and prospective memory (p<0.05). CONCLUSION: These findings support the effectiveness of MEST for MCI patients as a viable cognitive intervention. Also, the findings have implications for the role of brain plasticity in the effectiveness of this intervention.

Comprometimento cognitivo leve amnéstico (CCLA) é um dos perfis cognitivos do envelhecimento. OBJETIVO: Memory Specificity Training (MEST) foi usado como treino cognitivo em pacientes com CCLA para compreensão da efetividade da intervenção em dimensões da memória. MÉTODOS: Vinte pacientes que preencheram critérios para CCLA foram selecionados e randomizados para os grupos experimental (n=10) ou controle (n=10). O grupo experimental recebeu cinco sessões de treinamento em especificidade de memória enquanto que os pacientes do grupo controle participaram em duas sessões placebo. Os participantes foram avaliados antes e imediatamente após o tratamento e, três meses depois, usando o teste de memória autobiográfica, questionário de memória prospectiva e retrospectiva, escala de memória de Weschler e a escala hospitalar de depressão e ansiedade. A análise de variância foi usada para analisar os dados. RESULTADOS: Ambos os resultados, no pós-teste e no acompanhamento indicaram que o MEST melhora memória prospectiva e de trabalho (p<0.05). CONCLUSÃO: Estes achados suportam a efetividade do MEST para pacientes com CCL, como uma intervenção viável. Também, os achados têm implicações para o papel da plasticidade na efetividade desta intervenção.

Memory specificity training can improve working and prospective memory in amnestic mild cognitive impairment / Treino específico de memória pode melhorar memória de trabalho e prospectiva em pacientes com comprometimento cognitive leve amnéstico

ABSTRACT Amnestic Mild Cognitive Impairment (MCI) is one of the cognitive profiles of aging. OBJECTIVE: In this study, Memory Specificity Training (MEST) was used as cognitive training in patients with amnestic MCI to understand the effectiveness of the intervention on memory dimensions. METHODS: Twenty patients that met the criteria for amnestic MCI were selected and randomly assigned to experimental (n=10) or control (n=10) groups. The experimental group received five sessions of training on memory specificity while the participants in the control group took part in two general placebo sessions. Participants were assessed before, immediately after, and three months after, the treatment using the Autobiographical Memory Test, the Prospective and Retrospective Memory Questionnaire, the Wechsler Memory Scale, and the Hospital Anxiety and Depression Scale. Analysis of variance was used to analyze the data. RESULTS: Results from both post-test and follow-up treatment indicated that MEST improves working and prospective memory (p<0.05). CONCLUSION: These findings support the effectiveness of MEST for MCI patients as a viable cognitive intervention. Also, the findings have implications for the role of brain plasticity in the effectiveness of this intervention.

RESUMO. Comprometimento cognitivo leve amnéstico (CCLA) é um dos perfis cognitivos do envelhecimento. OBJETIVO: Memory Specificity Training (MEST) foi usado como treino cognitivo em pacientes com CCLA para compreensão da efetividade da intervenção em dimensões da memória. MÉTODOS: Vinte pacientes que preencheram critérios para CCLA foram selecionados e randomizados para os grupos experimental (n=10) ou controle (n=10). O grupo experimental recebeu cinco sessões de treinamento em especificidade de memória enquanto que os pacientes do grupo controle participaram em duas sessões placebo. Os participantes foram avaliados antes e imediatamente após o tratamento e, três meses depois, usando o teste de memória autobiográfica, questionário de memória prospectiva e retrospectiva, escala de memória de Weschler e a escala hospitalar de depressão e ansiedade. A análise de variância foi usada para analisar os dados. RESULTADOS: Ambos os resultados, no pós-teste e no acompanhamento indicaram que o MEST melhora memória prospectiva e de trabalho (p<0.05). CONCLUSÃO: Estes achados suportam a efetividade do MEST para pacientes com CCL, como uma intervenção viável. Também, os achados têm implicações para o papel da plasticidade na efetividade desta intervenção.

The Role of Mass Media in Iranian Youth's Premarital Sexual Relationships: A Qualitative Study.

BACKGROUND: Youth's sexual behaviors have various consequences such as unwanted pregnancy, acquired immunodeficiency syndrome and sexually transmitted infections. Little information is available about the impact of mass media in the development of premarital sexual relationships. This study aimed to explore the role of mass media on premarital sexual relationships among Iranian youth. METHODS: This qualitative study was conducted with 26 single boys and girls aged 18-24 years who were living in Isfahan, Iran and have already been started their sexual relationships. Also, 12 other participants who were involved in such an experience were recruited in this study. Data was collected using semi-structured interviews and the observation of youth's sexual interactions in different fields. Conventional content analysis method was used for data analysis. RESULTS: Three main categories were developed: "foreigner media as the role model", "the ease of access to sexual contents and materials" and "the ease of interactions and relationships with the opposite sex". CONCLUSION: The prominent role of mass media in the formation of premarital sexual relationships was described in this study. This issue needs to be taken into consideration by policy makers for taking necessary actions for reducing the impact of mass media on the youth's engagement in premarital sexual relationships.

Cognitive rehabilitation in patients with nonamnestic mild cognitive impairment.

BACKGROUND: The nonamnesic type of mild cognitive impairment (na-MCI) is predementia state with subtle decline incognitive domains except memory. Although cognitive rehabilitation (CR) has been investigated in amnesic type of MCI, we could not find any trial that rehabilitated na-MCI exclusively. We studied the effectiveness of CR on na-MCI. MATERIALS AND METHODS: This study was a blinded, randomized clinical trial. Individuals with age of 60 years or more, complete self-directedness and diagnosis of na-MCI, based on Neuropsychiatry Unit Cognitive assessment tool, were selected. The 51 patients were randomly assigned into three groups: CR, lifestyle (LS) modification, and the control group (CG). Neuropsychological tests for executive functioning were assessed at the baseline, after the interventions, and 6 months later. RESULTS: The mean score of the "design fluency" test increased significantly in CR, compared to LS and CG (P = 0.007). In "five-point" test, mean score increased significantly in CR (P = 0.03). There was higher mean score of Behavioral Rating Inventory of Executive Function for adults in CR (P = 0.01). CONCLUSION: Consideration of the MCI subtypes allows us to target specific cognitive domains, such as information processing, for better CR outcome. CR may result in better performance of executive functioning of daily living.

How does a group of Iranian youth conceptualize their risky sexual experiences?

BACKGROUND: There are restrictions as well as lawful and religious prohibition for sexual relationships in Iranian society. OBJECTIVES: This study explores the varied experiential reality of Iranian youth and their risky sexual experiences. PATIENTS AND METHODS: Data collection is based on semi-structured interviews with 30 single young men and women. Observation of interactions of youth in different settings has been another source of information. Interviews were microscopically content analyzed. RESULTS: The accounts of risky sexual experiences included gendered behavioral, cultural, and cognitive factors. In the re-contextualizing process, these accounts were categorized by two main themes: "gendered sexual script" and "cultural scenarios of interpersonal interactions". The notion of "male power" was evident in the responses provided by the participants. Women seldom asked for condom use due to limited knowledge about STIs-HIV/AIDS and unpleasant experiences with condoms. Men had limited knowledge about various sexual modes of HIV and STIs transmission and did not use condoms consistently because they had not seen themselves at risk of STIs or HIV as well as their belief about the decrease of sexual pleasure. CONCLUSIONS: Rising youth awareness, creating a positive attitude, and appropriate knowledge about safe sex practices are seminal. It is also vital to ensure access to gender specific sexual and reproductive health services for youths, empower women, and strengthen their sexual assertiveness as well as the elimination of all forms of gender-based inequalities.

Premarital sexual relationships: Explanation of the actions and functions of family.

BACKGROUND: Sexual behaviors of adolescents and youth are categorized as one of the main health priorities of a society because of high prevalence of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), sexually transmitted infections (STIs), and unwanted pregnancies. Family is an important environment that is associated with a range of social and emotional behaviors of children. This study was aimed at explaining the actions and functions of families in youths' engagement in sexual relations. MATERIALS AND METHODS: Twenty-six single males and females of 18-24 years who were living in Isfahan participated in this qualitative research study. The participants had begun to have some form of sexual activities. Twelve other participants including parents, teachers, school counselors, clinical psychologists, family counselors, and health care providers also took part in the study. Data collection method was based on semi-structured interview and observing the sexual actions and interactions of youths at different levels. In order to analyze the data, the researcher used constant comparison analysis of investigation. RESULTS: The results showed that five main concepts are involved in the formation of sexual relations before marriage, including "parents' child-rearing practices", "parents' interactions", "children's economic support", "religious beliefs," and "sexual awareness". CONCLUSIONS: Based on the prominent role of the family in shaping sexual relations before marriage, it is necessary to educate and support families and also revise the neglected aspects.

Cognitive impairments in patients with intractable temporal lobe epilepsy.

BACKGROUND: Cognitive impairment associated with temporal lobe epilepsy (TLE) has been recognized in multiple studies. We designed this study to find a specific cognitive profile in patients with TLE who were candidates for epilepsy surgery. We also sought to find if neuropsychological assessment could differentiate left TLE, right TLE and normal subjects. METHODS: The sample of this study consisted of 29 patients with right TLE, 31 with left TLE, and 32 subjects without history of seizure as the control group. For all recruited patients and controls, demographic questionnaire, Wechsler Memory Scale-III (WMS-III) and Wechsler Adult Intelligence Scale-R (WAIS-R) were administered. Multivariate analysis of variance was carried out to reveal differences in memory and intelligence performance between the three groups. RESULTS: All of the mean scores of the WMS-III indexes were significantly higher in the control group in comparison with the right or the left TLE groups (p < 0.001). There were not any significant differences between mean scores of WMS-III indexes of the right and the left. The WAIS-R also showed significantly better mean scores of full scale intelligence quotient (FSIQ) and performance intelligence quotient (PIQ) in the control groups than both of the right and left TLE patients (p < 0.001). Although the verbal intelligence quotient (VIQ) mean scores were significantly different between the left TLE and the control group (p = 0.037), there were not any significant differences between the right TLE patients and the control group. CONCLUSIONS: These findings indicated that WMS-III and WAIS-R can differentiate patients with refractory temporal lobe epilepsy from normal subjects. However, the obtained cognitive profile could not differentiate between the right and the left TLE.