Space-Confined Growth for Thickness-Controlled Cs3Bi2I9 Perovskite Single Crystal Wafers for X-Ray Detectors.

The Cs3Bi2I9 single crystal, as an all-inorganic non-lead perovskite, offers advantages such as stability and environmental friendliness. Its superior photoelectric properties, attributed to the absence of grain boundary influence, make it an outstanding X-ray detection material compared to polycrystals. In addition to material properties, X-ray detector performance is affected by the thickness of the absorption layer. Addressing this, a space-confined method is proposed. The temperature field is determined through finite element simulation, effectively guiding the design of the space-confined method. Through this innovative method, a series of thickness-controlled perovskite single crystal wafers (PSCWs) are successfully prepared. Corresponding X-ray detectors are then prepared, and the impact of single crystal thickness on device performance is investigated. With an increase in single crystal thickness, a rise followed by a decline in device sensitivity is observed, reaching an optimal value at 0.7 mm thickness at 40V mm-1 with a device performance of 11313.6µC Gy-1 cm-2. This space-confined method enables the direct growth of high-quality perovskite single crystals with specified thickness, eliminating the need for slicing or etching.

The effects of Tai Chi on standing balance control in older adults may be attributed to the improvement of sensory reweighting and complexity rather than reduced sway velocity or amplitude.

Introduction: Tai Chi has proved to be an effective therapy for balance performance and cognition. However, non-consistency exists in the results of the effect of Tai Chi training on standing balance control in older adults. This study aimed to use traditional and non-traditional methods to investigate the effect of Tai Chi on standing balance in older adults. Methods: Thirty-six Tai Chi practitioners (TC group) and thirty-six older adults with no Tai Chi practice (control group) were recruited in this study. A Nintendo Wii Balance Board was used to record the center of pressure (COP) during standing balance over 20 s in the condition of eyes closed with three repetitions. The wavelet analysis, multiscale entropy, recurrence quantification analysis, and traditional methods were used to evaluate the standing balance control in the anterior-posterior (AP) and mediolateral (ML) directions. Results: (1) Greater sway mean velocity in the AP direction and sway Path length were found in the TC group compared with the control group; (2) lower Very-low frequency band (0.10-0.39 Hz) and higher Moderate frequency band (1.56-6.25 Hz) in the AP and ML directions were found in the TC group compared with the control group; (3) greater complexity index (CI) and lower determinism (DET) in the AP and ML directions were observed in the TC group compared with control group; (4) greater path length linked with smaller Very-low frequency band in the AP and ML directions and higher Moderate frequency band in the AP direction in both groups; (5) greater path length linked with lower DET and higher CI in the AP direction only in the TC group. Conclusion: Long-term Tai Chi practice improved sensory reweighting (more reliance on the proprioception system and less reliance on the vestibular system) and complexity of standing balance control in older adults. In addition, greater sway velocity may be as an exploratory role in standing balance control of TC older adults, which correlated with greater complexity, but no such significant relationship in the control group. Therefore, the effects of Tai Chi practice on standing balance control in older adults may be attributed to the improvement of sensory reweighting and complexity rather than reduced sway velocity or amplitude.

Enhanced Efficiency and Stability of Inverted CsPbI2Br Perovskite Solar Cells via Fluorinated Organic Ammonium Salt Surface Passivation.

All-inorganic perovskite solar cells (PSCs) have recently received increasing attention due to their outstanding thermal stability. However, the performance of these devices, especially for the devices with a p-i-n structure, is still inferior to that of the typical organic-inorganic counterparts. In this study, we introduce phenylammonium iodides with different side groups on the surface of the CsPbI2Br perovskite film and investigate their passivation effects. Our studies indicate that the 4-trifluoromethyl phenylammonium iodide (CFPA) molecule with the -CF3 side group effectively decreases the trap density of the perovskite film by forming interactions with the undercoordinated Pb2+ ions and significantly inhibits the nonradiative recombination in the derived PSC, leading to an enhanced open-circuit voltage (Voc) from 0.96 to 1.10 V after passivation. Also, the CFPA post-treatment enables better energy-level alignment between the conduction band minimum of CsPbI2Br perovskite and [6,6]-phenyl C61 butyric acid methyl ester, thereby enhancing the charge extraction from the perovskite to the charge transport layer. These combined benefits result in a significant enhancement of the power conversion efficiency from 11.22 to 14.37% for inverted CsPbI2Br PSCs. The device without encapsulation exhibits a degradation of only ≈4% after 1992 h in a N2 glovebox.

Metaplastic breast carcinoma with osseous differentiation: A report of a rare case and literature review.

Metaplastic matrix-producing breast carcinoma is a type of metaplastic breast carcinoma (MBC), which is a rare malignancy, accounting for 0.2-1% of breast carcinomas. A 52-year-old female visited a hospital because of a palpable painless mass in the right breast and was diagnosed with Breast Imaging Reporting and Data System (BI-RADS) category 4A via ultrasound (US) with a suspected positive lymph node at the right axillary region. Excision of the breast mass was performed and histopathologically confirmed that it was MBC with osseous differentiation. No distant metastasis was revealed before a modified radical mastectomy; however, metastasis to a lymph node of the right axillary region was observed (1/22). She received six cycles of TEC scheme chemotherapy (docetaxel, epirubicin, and cyclophosphamide, 21 days) and 5 weeks of radiotherapy (48 Gy/25 f/5 days a week), but without any follow-up examinations since radiotherapy. Twenty-four months after surgery, distant metastases to lungs and liver were confirmed and died 3 months later. This case provides valuable information for clinicians on MBC and suggests that further examination or biopsy should be performed to US BI-RADS 4A masses before surgery. In addition, regular postoperative follow-up plays important roles in detecting metastases early and improving prognosis.

Sr-Doping All-Inorganic CsPbBr3 Perovskite Thick Film for Self-Powered X-ray Detectors.

The all-inorganic perovskite cesium lead bromine (CsPbBr3) has attracted much attention in the field of X-ray detectors because of its high X-ray absorption coefficient, high carrier collection efficiency, and easy solution preparation. The low-cost anti-solvent method is the main method to prepare CsPbBr3; during this process, solvent volatilization will bring a large number of holes to the film, leading to the increase of defects. Based on the heteroatomic doping strategy, we propose that Pb2+ should be partially replaced by Sr2+ to prepare leadless all-inorganic perovskite. The introduction of Sr2+ promoted the ordered growth of CsPbBr3 in the vertical direction, increased the density and uniformity of the thick film, and achieved the goal of CsPbBr3 thick film repairing. In addition, the prepared CsPbBr3 and CsPbBr3:Sr X-ray detectors were self-powered without external bias, maintaining a stable response during on and off states at different X-ray dose rates. Furthermore, the detector base on 160 µm CsPbBr3:Sr had a sensitivity of 517.02 µC Gyair-1 cm-3 at zero bias under the dose rate of 0.955 µGy ms-1 and it obtained a fast response speed of 0.053-0.148 s. Our work provides a new opportunity to produce cost-effective and highly efficient self-powered perovskite X-ray detectors in a sustainable way.

Promoting Active Aging Through Sports Participation: A Qualitative Exploration of Serious Leisure Among Older Chinese Adults.

China's population of older individuals reached 264.02 million in 2020, an increase of 5.44% from 2010. This study explores how participation in serious leisure sports, which have enduring benefits for older adults, contributes to active aging. In-depth interviews were conducted with 15 older participants aged 60-78 years who had participated in a leisure sport activity for 1 year or longer. A thematic analysis was conducted, and four themes emerged: body improvements, positive emotions, optimistic life attitudes, and social interactions. Older adults who participate in serious leisure sports are empowered via practice and learning opportunities to engage with their aging bodies, pursue psychological benefits, and jointly maintain leisure groups. The findings of this study contribute to our understanding of the "rights-based" approach to active aging and allow us to identify serious leisure sports as an active way for older adults to improve their quality of life.

The mediating role of psychological commitment between recreation specialization and life satisfaction: Evidence from Xiamen Marathon runners.

Although previous research spared no efforts to explain the life satisfaction of marathon runners, little was known about the relationship between recreation specialization (RS), life satisfaction (LS), psychological commitment (PC), and social support (SS). This study examines (i) how the dimension of RS (i.e., behavior, cognition, and affect) influences runners' PC and LS, and (ii) the mediating effects of PC and the moderating effects of SS on the relationship between behavior, cognition, affect, and LS. The results showed that behavior (ß = 0.15, p < 0.01), cognition (ß = 0.35, p < 0.001), affect (ß = 0.28, p < 0.001), and PC (ß = 0.59, p < 0.001) had significant and positive impacts on runners' LS; PC (Indirect path coefficient = 0.09 ~ 0.20) mediated the relationship between the dimensions of RS and LS. In addition, the results also confirmed the moderating effects of SS (ß = 0.10, p < 0.05) between affect dimension and LS. These findings offered more evidence for understanding how RS dimensions and PC influence runners' LS. Future research should integrate runner's leisure experiences to better understand the results revealed in this study.

The bs-YHEDA peptide protects the brains of senile mice and thus recovers intelligence by reducing iron and free radicals.

Iron accumulates in the brain with age and catalyzes free radical damage to neurons, thus playing a pathogenic role in Alzheimer's disease (AD). To decrease the incidence of AD, we synthesized the iron-affinitive peptide 5YHEDA to scavenge the excess iron in the senile brain. However, the blood-brain barrier (BBB) blocks the entrance of macromolecules into the brain, thus decreasing the therapeutic effects. To facilitate the entrance of the 5YHEDA peptide, we linked the low-density lipoprotein receptor (LDLR)-binding segment of ApoB-100 to 5YHEDA (named "bs-YHEDA"). The results of intravenous injections of bs-5YHEDA into senescent mice demonstrated that bs-YHEDA entered the brain, increased ferriportin levels, reduced iron and free radical levels, decreased the consequences of neuronal necrosis and ameliorated cognitive disfunction without kidney or liver damage. bs-5YHEDA is a safe iron and free radical remover that potentially alleviates aging and Alzheimer's disease.

The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells.

Papillary thyroid carcinoma (PTC) is a common thyroid malignancy. Circular RNAs (circRNAs) have been implicated in the development of PTC. Here, we explored the function and mechanism of circRNA family with sequence similarity 53, member B (circ_FAM53B) in PTC pathogenesis. Circ_FAM53B, microRNA (miR)-183-5p and coiled-coil domain containing 6 (CCDC6) levels were gauged by quantitative reverse transcription polymerase chain reaction (qRT-PCR) or Western blotting. The direct relationship between miR-183-5p and circ_FAM53B or CCDC6 was verified by dual-luciferase reporter and RNA immunoprecipitation (RIP) assays. Our data showed that circ_FAM53B expression was reduced in PTC tissues and cells. Circ_FAM53B expression restrained proliferation, migration, and invasion and triggered apoptosis of PTC cells, as well as hindered HUVEC tube formation. Circ_FAM53B repressed miR-183-5p expression. MiR-183-5p re-expression reversed the effects of circ_FAM53B on cell behaviors. MiR-183-5p targeted and inhibited CCDC6, and circ_FAM53B upregulated CCDC6 through miR-183-5p competition. MiR-183-5p knockdown repressed cell proliferation, migration, invasion, and tube formation and facilitated apoptosis by upregulating CCDC6. Furthermore, circ_FAM53B reduced tumor growth in vivo. Collectively, our findings suggest that circ_FAM53B affects PTC cell biological behaviors via the miR-183-5p-CCDC6 axis.

The Role of Recreation Specialization and Self-Efficacy on Life Satisfaction: The Mediating Effect of Flow Experience.

Previous studies confirmed that leisure sport participation could contribute to people's life satisfaction. However, little is known about the predictors of life satisfaction in the context of long-distance running. A model was proposed in this study to examine the relationship between recreation specialization, self-efficacy, flow experience, and life satisfaction. An online questionnaire was distributed to long-distance runners in China, and a total of 404 valid questionnaires were obtained for data analysis in this study. Results indicated that recreation specialization and self-efficacy had a direct and positive effect on runners' flow experience; recreation specialization, self-efficacy, and flow experience were positively associated with runners' life satisfaction. Furthermore, flow experience partially mediated the relationship between self-efficacy and life satisfaction, while it fully mediated the role of recreation specialization in life satisfaction. The findings shed some new insights for understanding the influence of leisure sport engagement on people's life satisfaction.

The Impact of Cycling Specialization on Successful Aging and the Mediating Role of Loneliness.

Recent studies have provided some evidence supporting that cycling specialization (CS) may be positively related to successful aging (SA) among elderly adults. However, there is a gap regarding the examination of the role of loneliness in the relationship between CS and SA. A hypothetical model was proposed to test the relationship between CS, SA, and loneliness. For this purpose, this study randomly conducted a questionnaire survey among 395 cycling participants over the age of 60 in China. The results showed that behavior, cognition, and affect had negative effects on loneliness. Behavior, cognition, and affect were positively associated with SA. Loneliness was negatively related to SA. Furthermore, behavior, cognition, and affect had positive and indirect effects on SA through loneliness. These results offered some new insights for understanding the relationship between CS and SA, especially considering the indirect effect of loneliness. The limitations and implications of the findings were discussed.

Women Runners in China: Constraints Negotiation Process of Serious Leisure.

The constraint negotiation process is a prominent part of serious leisure, and leisure-oriented women runners in China may behave differently in this process. An adjusted model was proposed to examine the constraint negotiation process of serious leisure for women runners. An online questionnaire was conducted that contained 239 valid samples measuring the participation, intrinsic motivation, constraints and negotiation of women runners. The structure of variables was confirmed based on the good results of reliability and validity test. Then the structural equation modeling results showed that constraints had a negative impact and negotiation had a positive impact on participation. Negotiation acts on constraints to reduce their negative perception. Furthermore, intrinsic motivation has a significant positive effect on negotiation. There are high intrinsic motivation and fewer constraints reporting for women runners under high negotiation in serious leisure. The results provide additional explanation for the serious leisure participation of women runners. Future research should integrate women's life experiences to better understand the behavior revealed in this study.

The Expression of GLAST and GLT1 in a Transient Cerebral Ischemia Mongolian Gerbil Model.

PURPOSE: Excitatory amino acid transporters (EAATs) have an indispensable function in the reuptake of extracellular glutamate. To investigate the relationship and the expression of neuronal and astrocytic markers after brain ischemia, the temporal profile of glial EAATs in both peripheral and core regions of the cortex was examined. METHODS: Transient common carotid artery occlusion was used to induce unilateral transient forebrain ischemia of Mongolian gerbils, and post-ischemic brains (6 h to 2 w) were collected and prepared for immunohistochemical and Western blotting analysis of glutamine synthetase (GS), GLT-1, GLAST, S100ß, and NeuN, and for Alizarin red staining of calcium deposits. RESULTS: The expression of GLAST and GLT-1 were significantly escalated at 6 h both in the core and periphery regions, while reduced from 12 h to 2 w in the core region post-ischemia. GS-positive cells increased at 6 h both in the core and periphery regions, while the density of Alizarin red-positive cells increased and peaked at 12 h in the ischemic cortex. The density of S100ß-positive cells decreased in the ischemic core and increased in the periphery region. Immunofluorescence staining showed that S100ß and TUNEL double-positive cells increased at 12 h in the core region. CONCLUSION: The results of GLT-1 and GLAST expression in the cortex indicate that their up-regulation was time-dependent and occurred in the acute post-ischemia period, whereas their down-regulation was region-dependent and it is involved in the pathological progress of nerve cell and glial cell death, and has a series of cascade reactions.

Treatment Of Magnesium-L-Threonate Elevates The Magnesium Level In The Cerebrospinal Fluid And Attenuates Motor Deficits And Dopamine Neuron Loss In A Mouse Model Of Parkinson's disease.

PURPOSE: Epidemiology research has demonstrated that magnesium (Mg) deficiency is associated with a high incidence of Parkinson's disease (PD). It is known that the systemic administration of MgSO4 is not able to elevate the Mg concentration in cerebrospinal fluid (CSF). This study aims to verify the protective effect of magnesium-L-threonate (MgT) in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model. METHODS: C57BL/6J mice were orally administered MgT or MgSO4 for 4 weeks, and received MPTP in the third week. After analysis of open-field and rotarod tests on the last day, tyrosine hydroxylase (TH) immunopositive cells and protein levels were quantified in the substantia nigra pars compacta (SNpc) and striatum. The expression of inducible nitric oxide synthase (iNOS) level was evaluated. Mg concentration in serum and CSF was measured after oral administration of MgSO4 or MgT in normal mice. Mg concentration in the CSF was increased in the mice treated with MgT but not MgSO4. RESULTS: The total distance and mean speed in open-field tests, and the time spent on rotarod in the MgT group were increased, compared with MPTP group. The MgT treatment but not MgSO4 dose-dependently attenuated the loss of TH-positive neurons, and the reduction of the TH expression in the SNpc. The MgT treatment also inhibited the expression of iNOS as measured by immunohistochemistry and Western blots. Double-immunofluorescence staining of TH and iNOS showed iNOS-positive cells were collocalized for TH-positive cells. CONCLUSION: The treatment with MgT is associated with an increase of Mg in the CSF. MgT, rather than MgSO4, can significantly attenuate MPTP-induced motor deficits and dopamine (DA) neuron loss.

Medical Data Management on Blockchain with Privacy.

Medical data are important in diagnosis, treatment, recovery, and medical accident investigation. The integrity and availability of medical data are the basic guarantee for the smooth operation of these activities. The privacy of medical data is a natural demand from the sensitivity of medical data. At present, there are mainly two ways to protect the privacy of medical data. One way is to store medical data in a local database and set up an access control strategy of the database. The other way is to encrypt medical data with the patient's key and to share the key when needed. The problem with the first method is that the data in the local database may be modified or deleted. The problem with the second method is that the key cannot be shared when the patient dies during the diagnosis and treatment. These two problems will damage the availability of data. This paper proposes to establish a shared key that could be reconstructed by the legitimate parties before the process of diagnosis and treatment begins. The data in the diagnosis and treatment process is encrypted and stored in a blockchain using the shared key. The proposal meets the integrity, availability and privacy requirements of medical data. It uses the sibling intractable function families (SIFF) to establish a shared key, and uses the Hyperledger Fabric to store encrypted data. The simulation shows that the system has good efficiency. Additionally, it is the first time to introduce SIFF to a blockchain application.

Linking the low-density lipoprotein receptor-binding segment enables the therapeutic 5-YHEDA peptide to cross the blood-brain barrier and scavenge excess iron and radicals in the brain of senescent mice.

INTRODUCTION: Iron accumulates in the brain during aging, which catalyzes radical formation, causing neuronal impairment, and is thus considered a pathogenic factor in Alzheimer's disease (AD). To scavenge excess iron-catalyzed radicals and thereby protect the brain and decrease the incidence of AD, we synthesized a soluble pro-iron 5-YHEDA peptide. However, the blood-brain barrier (BBB) blocks large drug molecules from entering the brain and thus strongly reduces their therapeutic effects. However, alternative receptor- or transporter-mediated approaches are possible. METHODS: A low-density lipoprotein receptor (LDLR)-binding segment of Apolipoprotein B-100 was linked to the 5-YHEDA peptide (bs-5-YHEDA) and intracardially injected into senescent (SN) mice that displayed symptoms of cognitive impairment similar to those of people with AD. RESULTS: We successfully delivered 5-YHEDA across the BBB into the brains of the SN mice via vascular epithelium LDLR-mediated endocytosis. The data showed that excess brain iron and radical-induced neuronal necrosis were reduced after the bs-5-YHEDA treatment, together with cognitive amelioration in the SN mouse, and that the senescence-associated ferritin and transferrin increase, anemia and inflammation reversed without kidney or liver injury. DISCUSSION: bs-5-YHEDA may be a mild and safe iron remover that can cross the BBB and enter the brain to relieve excessive iron- and radical-induced cognitive disorders.