The Chinese Spring Festival Impact on Air Quality in China: A Critical Review.

It is known that the sharp change of air pollutants affects air quality. Chinese Spring Festival is the most important holiday for Chinese people, and the celebration of the holiday with fireworks and the movement of people all around the country results in significant change in multiple air pollutant emissions of various sources. As many cities and rural areas suffer from the air pollution caused by firework displays and more residential fuel consumption, there is an urgency to examine the impact of the Chinese Spring Festival on air quality. Hence, this paper firstly gives an overall insight into the holiday's impact on ambient and household air quality in China, both in urban and rural areas. The main findings of this study are: (1) The firework displays affect the air quality of urban and rural atmosphere and household air; (2) the reduction in anthropogenic emissions improves the air quality during the Chinese Spring Festival; (3) the household air in urban areas was affected most by firework burning, while the household air in rural homes was affected most by fuel consumption; and (4) the short-term health impact of air pollution during the holidays also need more concern. Although there have been many publications focused on the holiday's impact on ambient and household air quality, most of them focused on the measurement of pollutant concentration, while studies on the formation mechanism of air pollution, the influence of meteorological conditions, and the health outcome under the effect of the Chinese Spring Festival are rare. In the future, studies focused on these processes are welcomed.

The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer.

In recent years, the insulin-like growth factor (IGF-1) and serine-arginine protein kinase 1 (SRPK1) have been reported to be implicated in the pithelial-mesenchymal transition (EMT) in many kinds of malignancies. However, the potential roles of IGF-1-SRPK1 signaling in the EMT of gastric cancer (GC) have not been investigated. In the present study, the in-vitro assays were used to investigate the molecular role of SRPK1 in cell cycle, motility and invasiveness. We demonstrated that the expressions of SRPK1 or insulin-like growth factor receptor 1 (IGF1R) were significantly increased in GC tissues and cells than those in normal tissues and GES-1 cells, and closely associated with metastasis, stage and prognosis. Western blot analysis showed that IGF-1 treatment can induce the expression of p-AKT and EMT biomarkers (N-cadherin, MMP2 and Slug) in a dose-dependent fashion in MGC803 and BGC823 cells. On the other hand, the knockdown of SRPK1 attenuated IGF-1-induced increase of EMT biomarkers and p-AKT. Besides, in-vitro analysis showed that knockdown of SRPK1 induced cell cycle arrest in G0/G1 phase, and affected cell migration and invasion. In conclusion, IGF-1-IGF1R pathway induced the expression of SRPK1 to control the progression of EMT via AKT pathway in the development of GC. Our findings lay a promising foundation for the IGF-1-IGF1R axis-targeting therapy in GC patients.