[The vaginal Bifidobacterium flora in women of reproductive age]. / Izuchenie bifidoflory vlagalishcha u zhebshchin reproduktivnogo vozrasta.

The composition of vaginal bifidoflora in 56 clinically healthy women of reproductive age was studied. The study revealed that four species of bifidobacteria, viz. Bifidobacterium bifidum, B. breve, B. adolescentis 2 and B. longum, dominated in the composition of this bifidobacterial population. Nine out of 11 isolated strains were found to be capable of inhibiting indicator microorganisms Staphylococcus aureus and Enterococcus faecalis when tested in vitro; in addition, strains B. adolescentis 2 F1, B. bifidum G1, B. breve P2 and B. longum Z4 inhibited Klebsiella ozaenae, Pseudomonas aeruginosa, Escherichia coli and were also active acid producers. Three of these 4 bifidobacterial strains were capable of adhesion to vaginal epitheliocytes, while B. bifidum G1 was practically incapable of adherence to these cells, similarly to B. bifidum strain 791 of intestinal origin. In addition, the spectra of antibiotic susceptibility varied from strain to strain, but all bifidobacterial strains were susceptible to benzylpenicillin and resistant to lomefloxacin, most of them being also resistant to cyprofloxacin and gentamicin. Thus the data presented in this work are indicative of the possibility and advantages of using bifidobacterial strains belonging to this ecological niche as probiotics for the correction of the microflora of the urogenital tract in females.

[The course of pregnancy induced by ovulation stimulation in patients with the hypogonadotropic form of amenorrhea]. / Techenie beremennosti, indutsirovannoi stimuliatsiei ovuliatsii u patsientok s gipogonadotropnoi formoi amenorei.

The course of 60 pregnancies induced by ovulation stimulation with pergonal (in 46 cases) and lutrelef, an LHRF agonist (in 10 cases) was followed up. The authors emphasize the importance of the first therapeutic course as a preparative one, because pregnancies occurred in only 15 and 20% of patients treated with the two drugs, respectively, after it, and 25% of them failed to develop. The major pregnancy complications were due to multiple fetuses (23.4 and 20%, respectively). Stimulated pregnancy should be regarded as a high risk one in respect of spontaneous abortions; indications for abdominal delivery should be extended in such cases.

[Experience in the use of fetal monitor MKP-01 Nadezhda]. / Opyt primeneniia fetal'nogo monitora MKP-01 "Nadezhda".

Cardiotocograms were studied in 40 women during timely labor with the use of Nedezhda MKP-01 fetal monitor with real-time automated processing of the following parameters: fetal basal heart beat rate, amplitude and length of decelerated heart beat rate, amplitude and frequency of oscillations of heart beat rate, time of delayed deceleration minimum with respect to the peak of a uterine contraction. Developing acute fetal hypoxia was detected in 3 cases, that permitted timely abdominal deliveries to preserve the fetuses. The described device was found highly informative and valuable.