Comparative Analysis of Infarct-Limiting Activity of Peptide and Non-Peptide δ- and κ-Opioid Receptor Agonists during Heart Reperfusion In Vivo.

A comparative analysis of the infarct-limiting activity of δ- and κ-opioid receptors (OR) agonists was carried out on a model of coronary occlusion (45 min) and reperfusion (120 min) in male Wistar rats. We used selective δ2-OR agonist deltorphin II (0.12 mg/kg), δ-OR agonists BW373U86 and p-Cl-Phe DPDPE (0.1 and 1 mg/kg), selective agonists of δ1-OR DPDPE (0.1 and 0.969 mg/kg), κ1-OR U-50,488 (0.1 and 1 mg/kg), κ2-OR GR-89696 (0.1 mg/kg), and κ-OR ICI-199,441 (0.1 mg/kg). All drugs were administered intravenously 5 min before reperfusion. Deltorphin II, BW373U86 (1 mg/kg), p-Cl-Phe DPDPE (1 mg/kg), U-50,488 (1 mg/kg), and ICI-199,441 had a cardioprotective effect. The most promising compounds for drug development are ICI-199,441 and deltorphin II.

[Functional reserves and adaptive potential of various levels of habitual motor activity].

On the basis of longitudinal studies in children of older preschool and early school-age boys and girls with low, medium and high habitual physical activity (NAPA, SPDA, VPDA) identified the basic characteristics of the cardiovascular system, physical capacity and the degree of tension of regulatory mechanisms at rest and during functional loading. Analysis of the statistical distribution of the trait given chi2 and lambda criteria and average data of various functional indicators in the total sample identified a fairly wide area and the divergent levels of physiological individuality in a healthy population and the desirability of allocating the three typological groups--functional types (FT-1 - NAPA, the FT-2 - SPDA, FT-3 - VPDA). Model parameters are allocated first and second order for each CFT, as well as performance tests of the third order, describing the current functional status. Determination of the physiological features of the FT-1 FT-2 FT-3 with the establishment of their functional reserves and adaptive capacity makes it possible to identify the different strategies of interaction with the environment, evaluate their advantages and disadvantages and a more grounded approach to the problem of optimization of physical condition and prenosological diagnosis.