Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros












Base de datos
Intervalo de año de publicación
1.
J Nephrol ; 23(1): 62-9, 2010.
Artículo en Inglés | MEDLINE | ID: mdl-20091488

RESUMEN

BACKGROUND: In end-stage renal disease, fetuin-A has been demonstrated to be reduced and inversely related to cardiovascular mortality. This study had 2 distinct aims. The first was to verify if circulating concentration of fetuin-A may depend on renal function in patients with chronic kidney disease (CKD). Furthermore, we analyzed the correlation of fetuin-A with the biomarker of endothelial dysfunction endothelin-1 (ET-1), and with the inflammatory cytokine interleukin-6 (IL-6). METHODS: In 108 subjects with stage 3-5 CKD, plasma levels of fetuin-A, ET-1 and IL-6 were assayed. Patients were studied first as a whole group and then were divided according to stages of CKD and fetuin-A tertiles. RESULTS: Fetuin-A concentration decreased in parallel with the increase in ET-1 and IL-6 levels as renal function declined. Multiple regression analysis showed that fetuin-A was independently associated with estimated glomerular filtration rate (beta=0.386; p<0.001), IL-6 (beta=-0.393; p=0.001) and ET-1 (beta=-0.219; p=0.02), in a multivariate model including also sex, parathyroid hormone and the calcium x phosphorus product. CONCLUSIONS: These results seem to indicate that in CKD, even when not severe, inflammatory processes are increased and linked to endothelial dysfunction, worsening progressively with the decline of renal function.


Asunto(s)
Proteínas Sanguíneas/metabolismo , Endotelio Vascular/fisiopatología , Tasa de Filtración Glomerular/fisiología , Enfermedades Renales/fisiopatología , Índice de Severidad de la Enfermedad , Anciano , Biomarcadores/sangre , Enfermedad Crónica , Estudios Transversales , Endotelina-1/sangre , Femenino , Humanos , Interleucina-6/sangre , Enfermedades Renales/sangre , Masculino , Persona de Mediana Edad , Hormona Paratiroidea/sangre , Valor Predictivo de las Pruebas , Análisis de Regresión , alfa-2-Glicoproteína-HS
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...