Novel foods, food enzymes, and food additives derived from food by-products of plant or animal origin: principles and overview of the EFSA safety assessment.

The European Union (EU) is committed to transitioning toward a circular economy model, with food waste being one of the areas to be targeted. To close the loop of food waste generated during food processing and discarded at the retail or consumption phases, research and innovation parties proposed to valorize agro-food by-products to produce novel foods and food improvement agents (food additives, food enzymes, and food flavorings). In the EU, the authorization of such novel foods and food improvement agents is governed by different regulatory frameworks. A centralized safety assessment by the European Food Safety Authority (EFSA) is the prerequisite for their authorization through the so-called Union Lists. Up to December 2023, EFSA published 45 scientific opinions on the safety of novel foods, food enzymes, and food additives derived from by-products of plant and animal origin. The current study illustrates examples of these by-products for the production of novel foods or food improvement agents and the data requirements behind their respective safety assessments conducted by EFSA. In this review, applications on novel foods, food enzymes, and food additives received by EFSA were screened and analyzed to find the common scientific requirements and differences in terms of the safety evaluation of such products. Various by-products (i.e., corncobs, coffee husks, spent grains of barley and rice, grape pomace, pumpkin peels, bovine whey, eggshells, shrimp heads, and animal organs or tissues) were described in the applications as being processed (extraction, physical treatments, and chemical and enzymatic reactions) to obtain novel foods and food improvement agents. The heterogeneity and complexity of these products emphasize the challenge of their safety assessment, depending on the characteristics of each product. However, as this study shows, the scientific requirements underpinning their safety do not differ substantially in the different regulated product areas considered, with similar information needed to assess their safety in terms of identity, production process, compositional characterization, proposed/intended uses and exposure assessment, toxicological information, and allergenicity data. Additional nutritional information and data on the history of use are required in the case of novel foods.

Intracranial graft of bioresorbable polymer scaffolds loaded with human Dental Pulp Stem Cells in stab wound murine injury model.

The prevalence of central nervous system (CNS) dysfunction as a result of disease or trauma remains a clinically unsolved problem which is raising increased awareness in our aging society. Human Dental Pulp Stem Cells (hDPSCs) are excellent candidates to be used in tissue engineering and regenerative therapies of the CNS due to their neural differentiation ability and lack of tumorigenicity. Accordingly, they have been successfully used in animal models of spinal cord injury, stroke and peripheral neuropathies. The ideal therapy in brain injury should combine strategies aiming to protect the damaged lesion and, at the same time, accelerate brain tissue regeneration, thus promoting fast recovery while minimizing side or long-term effects. The use of bioresorbable nanopatterned poly(lactide-co-ɛ-caprolactone) (PLCL) polymeric scaffolds as hDPCSs carriers can represent an advantage for tissue regeneration. In this chapter, we describe the surgical procedures to implant functionalized bioresorbable scaffolds loaded with hDPSCs to improve the brain lesion microenvironment in an intracranial stab wound injury model severing the rostral migratory stream (RMS) that connects the brain subventricular zone (SVZ) and the olfactory bulb in nude mice. Additionally, we also describe the technical steps after animal sacrifice for histological tissue observation and characterization.

Safety of vitamin D2 mushroom powder as a Novel food pursuant to Regulation (EU) 2015/2283 (NF 2020/2226).

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on vitamin D2 mushroom powder as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is produced from Agaricus bisporus mushroom powder that has been exposed to ultraviolet (UV) irradiation to induce the conversion of provitamin D2 (ergosterol) to vitamin D2 (ergocalciferol). The NF contains concentrations of vitamin D in the form of vitamin D2 in the range of 245-460 µg/g. The information provided on the production process, composition and specifications of the NF does not raise safety concerns. The applicant intends to add the NF as an ingredient in a variety of foods and beverages in amounts that result in either 1.2 or 2.4 µg vitamin D2 per 100 g or 100 mL of the food as consumed. The applicant also intends to add the NF in food supplements at a maximum of 15 µg vitamin D2/day for individuals above 1 year of age, as well as in foods for special medical purposes (FSMPs). The estimates for combined intake of vitamin D from the NF, the background diet and fortified foods, were below the ULs for vitamin D as established previously by the NDA Panel for children, adolescents and adults, i.e. 50 and 100 µg/day. The estimated combined vitamin D intake in infants (6-12 months) is also below the UL for vitamin D of 35 µg/day. The Panel considers that taking into account the composition of the NF and the proposed conditions of use, the consumption of the NF is not nutritionally disadvantageous for the proposed target population. The Panel concludes that the NF is safe under the proposed conditions of use.

Scientific and technical assistance to the evaluation of the safety of calcidiol monohydrate as a novel food.

EFSA was asked by the European Commission to provide scientific assistance with respect to the EFSA adopted scientific opinion on 'Safety of calcidiol monohydrate produced by chemical synthesis as a novel food pursuant to Regulation (EU) 2015/2283', including its bioavailability as a metabolite of vitamin D3 when added for nutritional purposes to food supplements. On 5 July 2023, EFSA adopted the 'Scientific opinion on the tolerable upper intake level for vitamin D, including the derivation of a conversion factor for calcidiol monohydrate'. This opinion concerns an updated exposure assessment for vitamin D and proposes a conversion factor for calcidiol monohydrate into vitamin D3 of 2.5 for labelling purposes. In addition, in reference to the EFSA opinion on the safety of calcidiol monohydrate, the Commission had received a letter from the pharmaceutical company EirGen Pharma Ltd requesting a revision of this opinion based on new data concerning calcidiol. Based on the information and data considered in this scientific technical report, EFSA concludes that the novel food calcidiol monohydrate proposed for use in food supplements is a bioavailable source of the biologically active metabolite of vitamin D, i.e. 1,25-dihydroxyvitamin D, that a conversion factor of 2.5 reflects the relative bioavailability of calcidiol vs vitamin D3 under the proposed conditions of use and use levels, and that it is safe under the proposed conditions of use and use levels, i.e. up to 10 µg/day for children ≥ 11 years old and adults, including pregnant and lactating women, and up to 5 µg/day for children 3-10 years of age.

Informe de caso: tuberculosis peritoneal en una mujer de 26 años simulando cáncer de ovario / Case report: peritoneal tuberculosis in a 26-year-old woman simulating ovarian cancer

Introducción: La tuberculosis peritoneal es una enfermedad reemergente, de evolución insidiosa y arduo diagnós- tico. La afectación peritoneal tiene una baja incidencia, afectando por igual ambos sexos figurando entre edades de 35 a 45 años. El alto índice de sospecha debe ser un factor importante en el diagnóstico precoz, para que una vez establecido, se pueda iniciar el tratamiento y disminuir las tasas de morbimortalidad. Descripción del caso clínico: Paciente de 26 años, con clínica inespecífica; dolor abdominal, ascitis y fiebre. Fue ingresada por servicio de medicina interna para abordaje etiológico de ascitis, posteriormente fue abordada como sospecha de cáncer de ovario, se presentó al servicio de cirugía quienes determinaron practicarle laparotomía y cuya biopsia intraoperatoria reporto hallazgos su- gestivos de tuberculosis peritoneal. Conclusión: La tuberculosis peritoneal es una enfermedad poco frecuente, las manifestaciones clínicas pueden sugerir la presencia de una enfermedad tumoral; la sospecha clínica es baja y en muchas ocasiones el diagnóstico es incidenta...(AU)

EXPERIENCIAS ANTE EL ABORTO EN ESTUDIANTES UNIVERSITARIAS DE QUERÉTARO, MÉXICO / ABORTION EXPERIENCES IN UNIVERSITY STUDENTS

INTRODUCCIÓN. El aborto, practicado de manera clandestina, puede implicar una serie de riesgos para la madre, sobre todo si esta es menor de edad o lo realiza sin el debido monitoreo médico. OBJETIVO. Describir las experiencias de jóvenes universitarias ante el aborto, mediante la realización de entrevistas a profundidad, con la finalidad de comprender el contexto del fenómeno. METODOLOGÍA. Estudio cualitativo, fenomenológico. Se entrevistaron a 3 estudiantes, elegidas por conveniencia, que vivieron un aborto de manera autoinducida. La pregunta generadora se sometió a validación por expertos y a estudio exploratorio. Las participantes aceptaron que sus entrevistas se grabaran, previo consentimiento informado. RESULTADOS. Se obtuvieron tres categorías de análisis. 1) ¿cómo me di cuenta que estaba embarazada?; las tres participantes no fueron plenamente conscientes del hecho, sino que la sintomatología propia del estado las "alertó". 2) ¿Cómo fue el proceso para la pérdida del feto? dos de las jóvenes utilizaron medicamentos administrados por distintas vías: uno oral y otro vaginal, la tercera participante utilizó té de ruda. 3) ¿qué pasó después? A pesar de que todas deseaban que el hecho quedara oculto a sus familias, sólo una lo logró. CONCLUSIÓN. Todas las jóvenes indicaron que esta experiencia las ha marcado. Sus comentarios denotan que no han superado el fenómeno a pesar de que ya tienen varios años de haberlo vivido. Señalan que no se arrepienten de su decisión, más que procurarán que no se repita la experiencia.

INTRODUCTION. Abortion, performed clandestinely, presents a series of risks for the mother, especially if she is underage or if she performs the procedure without proper medical supervision. OBJECTIVE. To describe the abortion experiences of university women through in-depth interviews, and thereby better understand the context of the phenomenon. METHODOLOGY. Qualitative, phenomenological study. 3 university students who lived through the experience of a self-induced abortion were interviewed, and the interview questions were validated by experts and an exploratory study. The participants agreed to have their interviews recorded by providing prior informed consent. RESULTS. There were three categories of analysis: 1) ¿How did I find out I was pregnant? The three participants were not fully conscious of the fact, but the symptoms of their state "alerted" them. 2) ¿What was the process for aborting the fetus? The women had different processes; two of them used medications administered by different routes: one oral and one vaginal. The third participant used tea made from the rue plant. 3) ¿What happened next? Even though they all wanted to hide the abortion from their families, only one succeeded. CONCLUSION. All three women interviewed indicated that this experience marked them. Their comments suggest that they haven't overcome the experience even though it happened several years ago. While they do not regret their decision, they are committed to ensuring that it will never happen again.

Safety of yellow/orange tomato extract as a novel food pursuant to Regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on yellow/orange tomato extract used as a novel food (NF) pursuant to Regulation (EU) 2283/2015. The NF which is the subject of the application is a carotenoid-rich extract from the yellow/orange tomato containing predominantly phytoene and phytofluene, as well as a lesser amount of beta-carotene, zeta-carotene and lycopene. The NF is produced from the tomato pulp using supercritical CO2 extraction. The applicant proposes the use of the NF in cereal bars, functional drinks and as a food supplement in individuals above 15 years of age. For the use of the NF in cereal bars and functional drinks, the Panel considers, the target population is the general population. According to EFSA's latest exposure assessment for lycopene as a food additive (EFSA ANS Panel, 2017), the highest P95 intakes for children (< 10 and 10-17 years) and adults when combined to the use of lycopene as a food colour from natural occurrence would exceed the established acceptable daily intake (ADI) for lycopene (0.5 mg/kg body weight (bw) day). The estimated intakes of the NF would lead to an exceedance of the ADI when considering natural occurrence and exposure to lycopene when used as a food additive. Due to the absence of safety data regarding phytoene and phytofluene intake from the NF, and the contribution of the NF to the estimated high daily intakes of lycopene, the Panel considers that it cannot be established whether or not the consumption of the NF is nutritionally disadvantageous. The Panel concludes that the safety of the NF has not been established under the proposed conditions of use.

Safety of the extension of use of partially defatted chia seed (Salvia hispanica L.) powder with a high fibre content as a novel food pursuant to Regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of the extension of use of partially defatted chia seed (Salvia hispanica L.) powder with a high fibre content as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is already authorised and included in the Union list of NFs and is produced according to the same production process. This application is limited to an assessment of the extension of use of the NF as a food ingredient in several food categories with a high moisture content that are subject to thermal processing. The target population for the extension of use is the general population. The information provided on the formation of process contaminants (acrylamide, furan and methylfurans) in a selected food category with added NF (bread) subjected to heat treatment is sufficient for this assessment and does not raise safety concerns. Noting that no safety concerns were identified from the information available on the production process, composition, specifications and proposed uses of the NF, the Panel considers that intake estimates for the NF are not needed for this assessment. The Panel concludes that the NF, partially defatted chia seeds powder with a high fibre content, is safe under the proposed conditions of use.

Actitudes hacia la sexualidad en adolescentes de bachillerato de la ciudad de Querétaro, México / Attitudes toward sexuality among high school adolescents in Queretaro city, Mexico

INTRODUCCIÓN. La sexualidad forma parte de cada etapa de la vida del ser humano, no obstante, en la adolescencia existe una pérdida de orientación, presión social por parte de sus iguales e información no precisa, lo que conduce a un inicio temprano de la vida sexual y consecuencias no deseadas. OBJETIVO. Determinar la actitud en adolescentes de bachillerato, hacia la sexualidad. METODOLOGÍA. Estudio transversal, descriptivo, realizado en el Colegio de Bachilleres del Estado de Querétaro, Plantel 1. El instrumento se denomina "Actitudes hacia el sexo", diseñado y validado en población queretana en 2017. RESULTADOS. Se aplicaron 264 instrumentos en jóvenes con edades de 15 a 16 años. Con respecto a las actitudes hacia el sexo, 32,6% no saben por qué tendrían sexo. Indican que les acarrearía mala reputación o pérdida de respeto hacia su persona si tuvieran relaciones sexuales, el 19,7% y 18,9%, respectivamente. Podrían sentirse culpables después de hacer el acto sexual el 22,3%. Tienen curiosidad de vivir la experiencia el 23,5%. Han iniciado con la práctica de relaciones sexuales el 38,6% aproximadamente a los 15 años, la mayoría. 6,1% ha tenido relaciones sin uso de un método de barrera y bajo el efecto del alcohol. CONCLUSIONES. La información obtenida refleja la necesidad de trabajar con los estudiantes en valores, inteligencia emocional, violencia, perspectivas de género, que favorezcan una visión clara de la sexualidad y una apropiada toma de decisiones.

INTRODUCTION. Sexuality is part of every stage of human life, however in adolescence the loss of orientation, social pressure from peers, and inaccurate information often leads to an early onset of sexual life and unwanted consequences. OBJECTIVE. To determine the attitude of high school adolescents towards sexuality. METHODOLOGY. Cross-sectional, descriptive study, conducted at High School Colegio de Bachilleres del Estado de Querétaro, Plantel 1. An instrument called "Attitudes towards sex" was designed and validated in the Queretano population in 2017. RESULTS. 264 instruments were administered to adolescents aged 15 to 16 years. With respect to attitudes towards sex, 32.6% did not know why they tend to have sex. Respondents were concerned that sex could result in a bad reputation (19.7%) or loss of their own self-respect (18.9%). Students could also feel guilty after sex (22.3%). 23.5% had curiosity about have sex. 28.6% of the teenagers surveyed started their sexual life at an average of 15 years; most of them have had sex without the use of a condom and under the influence of alcohol. CONCLUSIONS. The information obtained shows the necessity to work with the values, emotional intelligence, violence, and gender perspectives of adolescent students to help them develop a better perspective about sexuality and make appropriate decisions.

Estrés académico en estudiantes universitarios de enfermería de Querétaro, México / Academic stress in university nursing students from Queretaro, Mexico

INTRODUCCIÓN. Estudiar una carrera universitaria conlleva grandes retos académicos por lo que formase como Licenciado en Enfermería no es la excepción, incluso se considera una carrera de grandes exigencias y sacrificios que pueden implicar una serie de cuadros depresivos, de ansiedad y sobre todo estrés. OBJETIVO. Determinar el nivel de estrés que existe en los estudiantes universitarios de la Licenciatura en Enfermería de una institución educativa privada, mediante la aplicación de un cuestionario con la finalidad de conocer la situación actual de dicha población. METODOLOGÍA: Estudio cuantitativo descriptivo transversal que incluyo estudiantes de Enfermería. Para la recolección de los datos se utilizó una encuesta sociodemográfica, así como la aplicación del inventario SISCO-21. El análisis de los datos se realizó mediante el programa SPSS versión 25. Se aplicó estadística descriptiva. Se consideraron los aspectos éticos para la investigación en humanos. RESULTADOS: Se aplicaron 78 cuestionarios, donde 83,3% fueron mujeres. 38,5% indicaron sentir un nivel de estrés superior a 3 de 5. Los factores estresantes fueron el tiempo para hacer tareas, la poca claridad de los profesores e incluso, la personalidad del docente. Como reacciones manifestaron ansiedad, el 21,8%, siempre. CONCLUSIÓN: El nivel general de estrés fue leve, aunque sí se encontraron casos de alumnos que reflejaron niveles moderados e intensos, por lo que es importante el monitoreo y apoyo de los casos de alumnos que requieran apoyo.

INTRODUCTION. To study a university program implies academic challenges and being a nursing student is not an exception. Also, nursing it is a very demanding and sacrificed career who can pushed to every student into depressive situations, anxiety, but more, stress. OBJECTIVE. To determine the stress level on university students from Nursing School from a private school, thru a questionnaire trying to have an actual frame of the topic on these population. METHODOLOGY. Quantitative, cross sectional and descriptive study with nursing students. Data collection was made applying a sociodemographic cedula and the SISCO-21 inventory. Data analysis was made with SPSS 25th version program. Descriptive analysis was made. Ethical aspects were put in consideration. RESULTS. 78 instruments were applied; 83% of the students were female. 38.5% said to feel a superior level of stress, with 3 of 5. Stressors were time for homework, professors lack of clarity and, also, professors' personality. Some reactions were anxiety, always in 21.8% of students. CONCLUSION. The general stress level was low, although some students with moderate and high level were found. Monitoring and support it is important in case some students need support

Safety of vitamin D2 mushroom powder as a Novel food pursuant to Regulation (EU) 2015/2283 (NF 2019/1471).

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on vitamin D2 mushroom powder as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is produced from Agaricus bisporus mushroom that has been exposed to ultraviolet (UV) irradiation to induce the conversion of provitamin D2 (ergosterol) to vitamin D2 (ergocalciferol). The NF contains levels of vitamin D in the form of vitamin D2 in the range of 125-375 µg/g. The information provided on the production process, composition and specifications of the NF does not raise safety concerns. The applicant intends to add the NF as an ingredient in a variety of foods and beverages in amounts that result in either 1.125 or 2.25 µg vitamin D2 per 100 g or 100 mL of the food as consumed. The applicant also intends to add the NF in food supplements, for infants from 7 to 11 months at a maximum of 10 µg vitamin D2/day and of 15 µg vitamin D2/day for individuals aged 1 year or older, as well as in foods for special medical purposes (FSMPs) and total and meal diet replacement for weight control. For the adult population, the maximum intended use level in FSMPs is 15 µg vitamin D2/day and 5 µg vitamin D2/meal in total and meal diet replacement for weight control. The Panel concludes that the NF is safe under the proposed conditions of use. The Panel notes uncertainty regarding the calculated combined exposures to vitamin D for the general population, given the fact that the range of foods fortified with vitamin D has increased over the years, as well as the marketing of high-dose vitamin D supplements.

Safety of zinc l-carnosine as a Novel food pursuant to Regulation (EU) 2015/2283 and the bioavailability of zinc from this source in the context of Directive 2002/46/EC on food supplements.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on zinc l-carnosine as a novel food (NF) pursuant to Regulation (EU) 2015/2283 and as a source of zinc for use in food supplements. The NF is produced by chemical synthesis and is proposed to be used in food supplements as a source of zinc. The target population proposed by the applicant is individuals above the age of 12, excluding pregnant and lactating women. The NF which is the subject of the application is a chelate-complex, formed between Zn2+ and l-carnosine and is present as a mixture of a monomer and a dimer. The material is a powder with particulate nature and is insoluble in water at neutral pH. No relevant data using an existing zinc source as comparator have been made available by the applicant and the actual bioavailability of the zinc provided by the NF at the proposed use levels remains uncharacterised. Owing to the lack of a correct characterisation of the fraction of small particles, including nanoparticles of the NF, the Panel is not in the position to evaluate specification limits for the size of the constituent particles in the NF. Owing to the lack of information on the size distribution and the physico-chemical properties of the particles constituting the NF, the Panel is not in the position to confirm whether the ADME studies and the toxicological studies provided by the applicant are appropriate to assess the safety of the NF. The Panel concludes that the NF is absorbed and provides zinc, but as it is in an insufficiently characterised particulate form, its safety has not been established and the bioavailability has not been determined.

Safety of pea and rice protein fermented by Shiitake (Lentinula edodes) mycelia as a Novel food pursuant to Regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on pea and rice protein fermented by Shiitake mushroom (Lentinula edodes) mycelia as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is a mixture of fermented pea and rice protein concentrates (65% and 35%, respectively). The NF is proposed to be used as a food ingredient in specific food categories. The target population is the general population. The major constituent of this NF is protein (≥ 75% dry weight), which is well digestible and provides sufficient amounts of essential amino acids. Although a tolerable upper intake level (UL) has not been derived for protein, the protein intake from the NF may nevertheless further contribute to an already high dietary protein intake in Europe. The Panel notes that the cumulative exposure to the nutrients and contaminants analysed does not raise concern. The reported values for the levels of antinutritional factors in the NF are comparable to those in other foodstuffs. The Panel considers that taking into account the composition of the NF and the proposed conditions of use, consumption of the NF is not nutritionally disadvantageous. No toxicological studies with the NF were provided by the applicant; however, the Panel considers that no toxicological studies are required for this NF. The NF has the potential capacity to sensitise individuals or to induce allergic reactions in individuals allergic to pea, rice and Shiitake mushroom. However, this risk is expected not to be higher than that resulting from the normal consumption of pea, rice or the fruiting body of the Shiitake mushroom. The Panel considers that the NF is safe at the proposed conditions of use.

Estrés, ansiedad y consumo de drogas legales en trabajadores de la industria / Stress, anxiety and consumption of legal drugs in industry workers

INTRODUCCIÓN. El estrés y la ansiedad provienen de diferentes situaciones, pudiendo generar un aumento en el consumo de drogas lícitas. OBJETIVO. Valorar el estrés percibido, ansiedad, consumo de alcohol y tabaco en trabajadores operativos de una empresa de metal mecánica de la ciudad de Querétaro. MATERIALES Y MÉTODOS. Estudio transversal, descriptivo. Se aplicaron 4 formatos a través del uso de una plataforma digital, obteniendo la participación de 46 trabajadores. Se consideraron a trabajadores de ambos sexos, con una antigüedad mínima de 1 año. Se implementó una escala de estrés percibido, la escala de ansiedad de Hamilton, el Test Audit y una encuesta de consumo de tabaco. El análisis de los datos se llevó a cabo por en los programas SPSS versión 25 y Excel para Windows. El protocolo fue evaluado y aprobado por el Sub-Comité de Investigación y Bioética de la Facultad de Enfermería de la Universidad Autónoma de Querétaro. RESULTADOS. El promedio de edad fue de 33.48 años y 55.3% fueron varones. 28% sobresalieron de resto en el estrés percibido. 2% de los participantes manifestó una ansiedad muy severa y 7% moderada.15% se encuentra en la zona II de consumo de alcohol y han sido fumadores el 28.3% de los trabajadores. CONCLUSIÓN: Es necesario poder abordar al total de trabajadores y valorar de manera más cercana las variables estudiadas. Se identificaron casos de personas con situaciones de estrés y ansiedad que es necesario regular. Una vinculación con el departamento de salud sería la más conveniente.

INTRODUCTION: Stress and anxiety come from different situations, and can generate an increase in the consumption of legal drugs, especially in the work-industrial environment. OBJECTIVE: To determine the relationship between stress and anxiety with the consumption of legal substances in industry workers. METHODS: Several forms were applied through a digital platform, obtaining the participation of 47 workers of a company in Querétaro, where the frequency of consumption of legal drugs was evaluated, the data collection was carried out by the SPSS program version 14, the study lasted 6 months. RESULTS. Age average was 33.48 years and 55.3% were male. 28% obtained outstanding results in stress. 2% of participants had a very severe anxiety and 7% moderate. 15% is on zone two of alcohol consumption and have been smokers 28.3% of workers. CONCLUSION. It is necessary to address with all workers and value in a close way all studied variables. Some cases of stress and anxiety were identified, and it is necessary to approach. It is necessary a bonding with health department of the company.

Conocimientos y creencias sobre aspectos de salud sexual en adolescentes de una comunidad de Querétaro, México / Knowledge and believes about sexual health in teenagers from a rural area in Querétaro, Mexico

INTRODUCCIÓN. La adolescencia es una etapa en que la mayoría de este grupo etario inicia con su vida sexual, por ende, el problema en los adolescentes no es que sean sexualmente activos a temprana edad, sino que no cuentan con la preparación y orientación para una conducta sexual responsable, a consecuencia de ello se presentan conductas y factores de riesgo. OBJETIVO. Identificar los conocimientos y creencias sobre infecciones de transmisión sexual y embarazos no planificados en adolescentes de una comunidad rural de Querétaro. MATERIAL Y MÉTODOS. Investigación transversal descriptiva, realizada a 63 adolescentes. Se aplicó un cuestionario que consta de 86 preguntas divididas en cuatro secciones que abarcan: datos sociodemográficos, conocimientos sobre las infecciones de transmisión sexual, creencias y antecedentes de salud sexual. Se consideraron aspectos éticos en la investigación en humanos. RESULTADOS. 52,4% fueron del género femenino. Con respecto al nivel de conocimientos, 79,4% contestó erróneamente las preguntas planteadas. En relación a las creencias, llaman la atención afirmaciones como que la sexualidad fue creada para la reproducción, que todas las parejas deben tener hijos, efectos erróneos de los anticonceptivos, que el deber de la mujer es ser madre, entre otros aspectos. CONCLUSIONES. Es necesario reforzar el papel educativo del personal de enfermería en la educación sexual de los adolescentes en las zonas comunitarias.

INTRODUCTION. Adolescence it is a life period where these people start with sexual activity, and, with this situation, the problem is that they do not have proper preparation and information for an adequate sexual conduct and because of these, risk factors could be present. OBJECTIVE. To identify knowledge and believes about sexually transmitted diseases and unwanted pregnancies in adolescences from a rural community in Queretaro. MATERIAL AND METHODS. Cross sectional and descriptive research. 63 teenagers participated in the study. A questionary with 86 questions was applied, divided in four sections: sociodemographic data, knowledge about sexually transmitted diseases, believes and background about sexual health. Ethical aspects were considered. RESULTS. 52.4% female. Related with knowledge level, 79.4% answered in a wrong way. Regarded with believes, it was pointed out affirmations such: sexuality is just for reproduction, all couples must have children, fake effects of contraceptives, woman's duty must be being mother, and another. CONCLUSIONS. It is necessary to reinforce the educational paper of the nurse related with teenager's sexual life in rural areas.

Atención de enfermería en adultos jóvenes con insuficiencia renal aguda: Revisión narrativa / Nursing care in young adults with acute kidney failure: Narrative review

El daño renal está reconocido como la reducción de la función renal, el cual se ve generalmente reflejado por una caída en la diuresis. A nivel mundial, el porcentaje de personas que padece daño renal va en aumento, esto debido a múltiples aspectos. En este sentido, se reconoce que el personal de enfermería es quien idóneamente tiene un gran rol en la educación de la población, para la prevención del daño renal agudo, previniendo con ello el daño renal crónico. De esta manera, en el escrito se abordan aspectos generales más relevantes, de la hidratación, la alimentación, la actividad física, el consumo de alcohol, la automedicación y la prevención de infecciones de las vías urinarias, como parte de los aspectos modificables y en los que las personas tienen directa injerencia en sus acciones, con la debida información, con los que el personal de enfermería puede reforzar sus recursos en materia de educación a la población. De la misma manera, se muestran estudios de diseño cuasiexperimental, como una manera de resaltar que puede medirse el impacto de la educación en la población en una época en donde requerimos tener mayor evidencia de la efectividad de las intervenciones que realicemos.

Renal insufficiency it is recognized as the reduction of the renal function, reflected by the decreased urine output. Worldwide, the amount of people whom have renal insufficiency it is growing, by many reasons. Because of this, is recognized that nursing staff is the best option at the population education, in order to prevent acute renal insufficiency, preventing with this, chronical renal insufficiency. In this document, it is possible to review, the most important general aspects of hydration, feeding, physical activity, alcohol consumption, self-medication and prevention of urinary tract infections, as part of modifiable aspects that people handle as part of their personal health actions, with the proper information, with which nursing staff can strengthen their resources in health education to the population. In this way, this paper shows some quasi-experimental studies, as a way to highlight that it is possible to measure the impact of population education, in a moment that the health system requires more evidence of the effectiveness of the interventions.

Safety of calcidiol monohydrate produced by chemical synthesis as a novel food pursuant to Regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the safety of calcidiol monohydrate as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including its bioavailability as a metabolite of vitamin D3 when added for nutritional purposes to food supplements. The NF is produced chemically. It is proposed in food supplements up to 10 µg/day for individuals ≥ 11 years of age, including pregnant and lactating women and up to 5 µg/day in 3- to 10-year-old children. The production process, composition, specifications and stability of the NF do not raise safety concerns. Animal and human data indicate efficient absorption. The NF contains a fraction of nanoparticles, which are fat soluble and unlikely to reach systemic distribution. There are no concerns regarding genotoxicity. Human adult studies do not raise safety concerns. Combined intake estimates of calcidiol from the NF and calcidiol and vitamin D from the diet were below the tolerable upper intake level (UL) for vitamin D for subjects above 11 years of age. The achieved mean serum 25(OH)D concentration in adults supplemented with 10 µg NF per day remained below 200 nmol/L. The Panel concludes that the NF is safe under the proposed conditions of use and use levels for individuals ≥ 11 years old, including pregnant and lactating women. The applicant did not provide data on the bioavailability and safety of the NF in children. The combined intake estimation in children (3-10 years) is close to the UL for vitamin D. Therefore, the Panel could not conclude on the safety of consumption of the NF in children (3-10 years) at the proposed daily intake. The NF is a bioavailable source of the biologically active metabolite of vitamin D, i.e. 1,25-dihydroxyvitamin D.

Safety of Vitamin D2 mushroom powder (Agaricus bisporus) as a Novel food pursuant to Regulation (EU) 2015/2283.

Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on vitamin D2 mushroom powder as a novel food (NF) pursuant to Regulation (EU) 2015/2283. The NF is an ingredient produced from Agaricus bisporus mushroom powder that has been exposed to ultraviolet (UV) irradiation to induce the conversion of provitamin D2 (ergosterol) to vitamin D2 (ergocalciferol). The NF contains concentrations of vitamin D provided by vitamin D2 in the ranges of 580-595 µg/g. The information provided on the manufacturing process, composition and specifications of the NF does not raise safety concerns. The applicant intends to add the NF in a variety of foods and beverages, including food for special medical purposes and food supplements. The target population is the general population except for food supplements and Foods for Special Medical Purposes (FSMPs), for which the target population is individuals above 1 year of age. The Panel concludes that the NF, used as an ingredient, is safe for the general population at the proposed condition of use in foods and beverages and that the NF used as a food supplement, is safe for individuals above 1 year.

Fear, Stress, and Knowledge regarding COVID-19 in Nursing Students and Recent Graduates in Mexico.

OBJECTIVES: The study sought to correlate fear, stress, knowledge regarding COVID-19 in Nursing students and recent graduates in Mexico. METHODS: Correlational design, sample comprising 912 nursing students and graduates during the last 18 months from public and private universities of Mexico. To measure the variables, the study applied the instrument Fear of COVID-19 Scale, knowledge subscale of the scale Knowledge, attitudes, and practices towards COVID-19, and the instrument COVID Stress Scale. RESULTS: Relationship was found of the age variable with fear, danger of contamination, traumatic stress, knowledge and minor socioeconomic consequences (p<0.05). Likewise, relationship was observed of fear with stress regarding COVID-19, danger of contamination, socioeconomic consequences, xenophobia, traumatic stress, and compulsive checking (p<0.05). Stress and knowledge explain the presence of fear regarding COVID-19 in 50.3%, and fear and knowledge explain stress regarding COVID-19 in 50.4%. CONCLUSIONS: Nursing students and recent graduates have high levels of stress and fear, besides low level of knowledge. The presence of high stress and low knowledge predict fear regarding COVID-19. Interventions are required on knowledge, stress, and fear regarding COVID-19 in the population studied.

Fear, Stress, and Knowledge regarding COVID-19 in Nursing Students and Recent Graduates in Mexico

Objective. The study sought to correlate fear, stress, knowledge regarding COVID-19 in Nursing students and recent graduates in Mexico. Methods. Correlational design, sample comprising 912 nursing students and graduates during the last 18 months from public and private universities of Mexico. To measure the variables, the study applied the instrument Fear of COVID-19 Scale, knowledge subscale of the scale Knowledge, attitudes, and practices towards COVID-19, and the instrument COVID Stress Scale. Results. Relationship was found of the age variable with fear, danger of contamination, traumatic stress, knowledge and minor socioeconomic consequences (p<0.05). Likewise, relationship was observed of fear with stress regarding COVID-19, danger of contamination, socioeconomic consequences, xenophobia, traumatic stress, and compulsive checking (p<0.05). Stress and knowledge explain the presence of fear regarding COVID-19 in 50.3%, and fear and knowledge explain stress regarding COVID-19 in 50.4%. Conclusion. Nursing students and recent graduates have high levels of stress and fear, besides low level of knowledge. The presence of high stress and low knowledge predict fear regarding COVID-19. Interventions are required on knowledge, stress, and fear regarding COVID-19 in the population studied.

Objetivo. Correlacionar el temor, estrés, conocimientos frente al COVID-19 en estudiantes y recién egresados de enfermería en México. Métodos. Diseño correlacional, muestra constituida por 912 estudiantes de enfermería y egresados en los últimos 18 meses de universidades públicas y privadas de México. Para medir las variables se aplicó el instrumento Fear of COVID-19 Scale, subescala de conocimientos de la escala Knowledge, attitudes, and practices towards COVID-19, y el instrumento COVID Stress Scale. Resultados. Se encontró relación de la variable edad con temor, peligro de contaminación, estrés traumático, conocimientos y menores consecuencias socioeconómicas (p<0.05). De igual forma, se observó relación del temor con estrés ante el COVID-19, peligro de contaminación, consecuencias socioeconómicas, xenofobia, estrés traumático, y comprobación compulsiva (p<0.05). El estrés y los conocimientos explican la presencia del temor ante el COVID-19 en un 50.3 %, así como el temor y conocimiento explican el estrés ante el COVID-19 en un 50.4 %. Conclusión. Los estudiantes y recién egresados de enfermería tienen altos niveles de estrés y temor, además de bajo nivel de conocimientos. La presencia de alto estrés y bajos conocimientos predicen el temor ante del COVID-19. Se requieren intervenciones sobre los conocimientos, estrés y temor ante el covid-19 en la población estudiada

Objetivo. Correlacionar medo, estresse, conhecimento contra COVID-19 em estudantes e recém-formados em enfermagem no México. Métodos. Desenho correlacional, amostra composta por 912 estudantes e graduados de enfermagem nos últimos 18 meses de universidades públicas e privadas do México. Para mensurar as variáveis, foram aplicados o instrumento Escala de Medo do COVID-19, a subescala Conhecimento da escala Conhecimento, atitudes e práticas em relação ao COVID-19 e o instrumento Escala de Estresse COVID. Resultados. Foi encontrada relação entre a variável idade e medo, perigo de contaminação, estresse traumático, conhecimento e menores consequências socioeconômicas (p<0.05). Da mesma forma, foi observada relação entre medo e estresse frente ao COVID-19, perigo de contaminação, consequências socioeconômicas, xenofobia, estresse traumático e verificação compulsiva (p<0.05). O estresse e o conhecimento explicam a presença do medo do COVID-19 em 50.3%, assim como o medo e o conhecimento explicam o estresse do COVID-19 em 50.4%. Conclusão. Estudantes de enfermagem e recém-formados apresentam altos níveis de estresse e medo, bem como baixo nível de conhecimento sobre o COVID-19. A presença de alto estresse e baixo conhecimento prediz medo de COVID-19. Se faz necessário intervenções sobre o conhecimento, estresse e medo de covid-19 na população estudada.