Non-invasive assessment of tumor proliferation using triple quantum filtered 23/Na MRI: technical challenges and solutions.

We address the development of triple-quantum-filtered sodium MRI as a non-invasive surrogate measure for cell proliferation in brain tumors. We demonstrate that through careful consideration of the theoretical description of the signal, triple-quantum-filtered sodium images of adequate signal-to-noise ratio (SNR) can be acquired in clinically acceptable imaging times.

Mapping therapeutic response in a patient with malignant glioma.

Short-interval scanning of patients offers a detailed understanding of the natural progression of tumor tissue, as revealed through imaging markers such as contrast enhancement and edema, prior to therapy. Following treatment, short-interval scanning can also provide evidence of attenuation of growth rates. We present a longitudinal imaging study of a patient with glioblastoma multiforme (GBM) scanned 15 times in 104 days on a 3 T MR scanner. Images were analyzed independently by two automated algorithms capable of creating detailed maps of tumor changes as well as volumetric analysis. The algorithms, a nearest-neighbor-based tissue segmentation and a surface-modeling algorithm, tracked the patient's response to temozolomide, showing an attenuation of growth. The need for surrogate imaging end-points, of which growth rates are an example, is discussed. Further, the strengths of these algorithms, the insight gained by short-interval scanning, and the need for a better understanding of imaging markers are also described.

[Adrenal myelolipoma associated with lithiasic cholecystitis, hiatal hernia and esophagitis]. / Mielolipoma adrenal vinculado a colecistitis litiásica, hernia hiatal y esofagitis.

UNLABELLED: The adrenal myelolipoma are rare tumors that are generally asymptomatic, unilateral and nonfunctional and in the majority of the cases they are found incidentally. OBJECTIVE: Is to present a clinical case of adrenal myelolipoma, associated with gallstones. CASE REPORT: A 30 year old obese female with chronic abdominal pain, which underwent a GI series, having found a hiatal hernia and esophagitis. An ultrasound, of the gallbladder and bile ducts showed gallstones and incidentally a tumor of 9.3 x 8 x 7 cm was found between the right kidney and the liver. In the CT of the abdomen of observed, a little vascularized tumor of the adipose composition of 9.2 x 6 x 5 cm over the top of the right kidney. A cholecystectomy was performed and the resection of the tumor, histopathological study of the tumor reported normal adrenal tissues, mature adiposis and hematopoietic with all of its series. CONCLUSIONS: The association of adrenal myelolipoma and gallstones is not common and it could be an incidental association. With the new tools available we can diagnose the adrenal myelolipoma with a greater degree of certainty.