RESUMEN
Cancer patients in adolescents and young adults (AYA) generation aged 15-39 years have various psychosocial needs during their treatment course such as school enrollment, finding employment, marriage, and fertility. It is difficult for medical professionals to gain experience related to providing medical care and consultation support to these kinds of AYA generation cancer patients. There is a need to provide information and establish both support and medical care systems that are able to meet the diverse needs unique to this generation. This review will explain how to launch an AYA support team (AST). We have worked and established the AST since 2016, which is medical care teams that provide support according to the life stage of each individual patient and build a multidisciplinary AYA generation patient support system. The team-building process consisted of two main projects: building and enlarging multidisciplinary team and establishing screening process of psychosocial needs of AYA generation patients. Multidisciplinary healthcare professionals got involved in the AST with already-existing patient support functions in our center: the patient support center, which is an outpatient department and the palliative care team, which is an inpatient interdepartmental team. The AST systematically finds patients in need of assistance and offers them support as a multidisciplinary team. The AST also established a procedure that systematically gathers information about the needs of patients by using a screening tool. In addition, the AST provides the following specialized services: reproductive medicine, supporting cancer patients with children, employment support, and peer support. The AST has been established and sophisticatedly worked. It can flexibly provide various psychosocial support services. This review will explain how to launch an AST.
RESUMEN
The ring-cleavage reactions of a series of benzocycloalkenes were studied using an ArF excimer laser. Product formation was significantly suppressed in the presence of nitrogen; therefore, the presence of vibrationally excited states (hot molecules), as intermediates, was indicated. The product of highly strained benzocyclobutene was linearly proportional to the laser fluence, whereas those of benzocyclopentene and benzocyclohexene were proportional to the square of the laser fluence in the presence of nitrogen. These phenomena cannot be understood as photochemical bond cleavage in the electronic excited state, but instead appear to be the result of single- and two-photon reactions of hot molecules. The dissociation rate constants were evaluated by a statistical rate theory under the assumption that the reaction occurred from the hot molecule. The reaction rate of highly strained benzocyclobutene was predicted to be faster than the collisional rate with foreign gas, even if it had vibrational energy equivalent to one photon; however, the reaction rates of less strained benzocyclohexene were expected to compete with the collisional rate when the vibrational energy was equivalent to two photons. Benzocyclopentene was an intermediate case and showed both single- and two-photon reactions. The dissociation rate constant of 1.4 x 10(6) s(-1) was successfully obtained from benzocyclopentene under collision-free conditions. This value was in fair agreement with the calculated value. The different dissociation rate constants of the molecules were well-explained in terms of the strain energy. Although the strain energy varies in a wide range (10-130 kJ mol(-1)), the simple model of the calculations reproduced the observed values of the CH2-CH2 bond dissociation in strained benzocycloalkenes.