[EXISTENTIAL ORGANIZATION OF BRAIN BIOELECTRICAL ACTIVITY OF THE OFFSPRING OF RATS AFTER VITAL STRESS].

An association was found between severity of behavioral disturbances in the offspring of rats that survived the stress, and changing spatial-temporal organization of the ECOG. The proportion of synchronous activity in the right frontal and left occipital regions with respect to the right nape, and between the frontal leads increases with the minimum deviations of behavior. The proportion of ahead activity increased in frontal leads; reduced the share of lagging and an increasing proportion of synchronous bioelectrical activity in relation to the right occipital region in case of serious disorders of behavior.

Modification of Anxious Behavior after Psychogenic Trauma and Treatment with Galanin Receptor Antagonist.

Effects of blockage of central galanin receptors on anxiety manifestations were studied in rats with psychogenic trauma. Psychogenic trauma was modeled by exposure of a group of rats to the situation when the partner was killed by a predator. Antagonist of galanin receptors was intranasally administered before stress exposure. Animal behavior was evaluated using the elevated-plus maze test, free exploratory paradigm, and open-field test. Psychogenic trauma was followed by an increase in anxiety level and appearance of agitated behavior. Blockage of galanin receptors aggravated behavioral impairment, which manifested in the pathological anxious reactions - manifestations of hypervigilance and hyperawareness. The results suggest that endogenous pool of galanin is involved into prevention of excessive CNS response to stressful stimuli typical of posttraumatic stress disorder.

[Influence of maternal factor on motor behavior and lipid turnover in rats exposed to severe psychoemotional stress].

Adverse condition of rat development during the prenatal period (rearing by mother survived brain injury) or during the early post-natal period (cross fostering), causes impairment of motor behavior and a lipid turnover in adult rats. Such rats under severe stress showed decrease of adaptation (as expressed or low indexes of motor impellent behavior and lipid metabolism) in comparison with rats that were grown up by own mother. The psychoemotional stress caused the most expressed deficient behavior in males that were grown up by mothers with brain injury (decrease in serum level of HC and HDL and depressively - similar behavior).

[Features of an existential organization of a bioelectric activity of the brain at posterity from rats with a lateral injury of the brain].

Features of the existential organization of a bioelectric activity of a brain at posterity from rats with a lateral injury of the brain were investigated. The EEG analysis revealed in one month animals significantly increased the proportion of advanced and lagging decrease in the activity of the right frontal derivation towards the right occipital region. Change between structural ties in terms of the rats were correlated with the severity of behavioral disorders in the test "open field" (OF). The most significant change in the existential organization of a bioelectrical activity (the reduction of synchronous communications between the frontal derivations) recorded in rats with severe conduct disorder compared with animals of the same groups, in which the behavior was not significantly different from the norm. The violation of the behavior in the test OF was accompanied by a decrease in synchronous activity between the left frontal and right occipital region or the decline in the anticipatory activity in the right frontal region in relation to the right occipital region. By maintaining the integrity of the behavior of these parameters were increased in comparison with an intact control.

[Peculiarities of behavior of offspring of rats-ambidexters after surviving vital stress].

Psychogenic trauma inflicted to mothers (Wistar rats) during pregnancy is more tragic for establishment of psychoemotional functions in offspring than in the rat pups whose mothers survived prior to pregnancy the stress connected with threat of life. The "antenatal stress" causes in the one-month-old offspring the depression-like behavior, while the stress one month prior to conception--the increased anxiety. Disturbances of the integral behavior in the test "open field" can be caused both by the acute psychogenic trauma of mothers and by its delayed consequences. The sharp impoverishment of behavior and the more pronounced psychoemotional disturbances are realized in female individuals regardless of the terms of the action. In the male offspring the vital stress during their mothers' pregnancy produces the rougher behavioral disturbances than stress prior to conception.

[Agonist of V2 vasopressin receptor reduces depressive disorders in post-stroke patients].

Poststroke depression is one of the common psychiatric complications after stroke. Thus, the research of new ways for treatment depressed mood after stroke is actual. The previous researches revealed vasopressin to be effective in patients with memory, speech and motor function disorders after stroke. The purpose of the study was to investigate influence of vasopressin on depression after stroke. Fourteen patients with affective disorders have been treated with subendocrine doses of 1-desamino-8-D-arginin-vasopressin (DDAVP) daily by intranasal application during 1,5-2 months. Vasopressin was effective in correcting both apatoadinamic and anxious depression. Treatment effect was durable, lasts for 0,5-1 year after the first course of therapy. The results of this pilot study demonstrate perspective of using selective agonist of vasopressin V2 receptors, DDAVP, in therapy of post-stroke depression.

Mesenchymal stem cells restore orientation and exploratory behavior of rats after brain injury.

We studied the effects of intravenous and intracerebral transplantation of MSC on restoration of orientation and exploratory behavior of Wistar-Kyoto rats after removal of the left motor cortex. Removal of the motor cortex led to a significant reduction of the number of behavioral acts in the open field test. Two weeks after removal of the motor cortex and intravenous transplantation, the animals were as inhibited as the controls, but during the next 10 weeks, the behavioral status of these rats remained unchanged, while controls exhibited further behavioral degradation. After injection of MSC into the brain, the behavior of rats with trauma did not change in comparison with intact rats over 10 weeks.

Changes in the lipid composition of blood plasma and liver in rats induced by severe psychic trauma.

The concentration of high-density lipoprotein cholesterol and triglycerides in rat serum sharply decreased after psychic trauma caused by life hazard. The content of these substances remained unchanged for not less than 1 week after trauma. The concentration of high-density lipoprotein cholesterol was low, while serum content of triglycerides increased 6 weeks after trauma. The concentration of high-density lipoprotein cholesterol significantly decreased after repeated psychic trauma. These changes were accompanied by a sharp increase in the concentration of triglycerides in the serum. Total cholesterol concentration in the liver decreased under these conditions.

[Neuropeptide induction of compensatory processes at aphasias]. / Neiropeptidnaia induktsiia kompensatornykh protsessov pri afaziiakh.

Dynamic changes of speech function were studied in patients with persistence aphatic disorders after stroke under the conditions of application of V2 vasopressin receptor agonist (1-desamino-8-D-arginin-vasopressin). A course of intranasal administration of the medical drug by using the double blind control showed a reliable reduction of frustration severity of expressive and impressive speech in patients with aphasias of different forms and degrees. A correlation of positive influence of vasopressin on speech, verbal memory and attention was found at efferent motor aphasias. The achieved effects preserved during a two-year catamnestic observation period. A repeated course of therapy resulted in an additional improvement of speech. Neuropeptide restored initially, in patients with aphasias, relatively simple forms of speech and later--complicated ones. This resulted in an improvement of speech functions which are regulated by both cerebral hemispheres. Supposedly, neuropeptide optimized the activity of both the right and left cerebral hemispheres. The stability of the obtained effects is explained by induction, due to vasopressin, of compensatory processes leading to reorganization of intercentral connections.

[Modulation of emotional reactions via biocontrolled readjustment of intercentral relations]. / Moduliatsiia émotsional'nykh reaktsii posredstvom bioreguliruemoi perestroiki mezhtsentral'nykh otnoshenii.

In cats, changes in the feedback between the strength of current used for hypothalamic stimulation and the theta--rhythm of temporal cortex exert diverse effects on conditioned response of fear evolved by means of combining an auditory stimulus with electrical stimulation of the same hypothalamic area. Biocontrolled micropolarizattion (BMP) with positive feedback suppresses, whereas BMP with negative feedback enhances the conditioned response. The changes in the feedback during BMP between excitation of temporal cortex and the hypothalamus seem to be a modulation of connections between the centers of conditioned and unconditioned stimuli.

[Analysis of the interstructural relationships in the brain by the method of bioregulated micropolarization]. / Analiz mezhstrukturnykh sviazei mozga s pomoshch'iu metoda bioreguliruemoi mikropoliarizatsii.

In chronic experiments on cats, automatic regulation of polarizing current, monitored with the EEG changes, aided to study elements of the cerebral selfregulating system. The method proved effective for influencing the functional state of the structures to be regulated which revealed itself in long-lasting shifts of theta-rhythm, in changes of excitability and readjustment of EPs. Three types of connections between the temporal cortex and a number of cerebral modulating structures: rigid (positive and negative) and flexible those, were revealed. The active inhibition was accelerated with the bioregulated micropolarization of temporal cortex and hypothalamus on extinction of alerting response.