Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Más filtros












Base de datos
Intervalo de año de publicación
1.
Nat Prod Res ; 38(5): 735-743, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-37021784

RESUMEN

Five undescribed oleanane triterpene glycosides named chryroxosides A-D (1-5), together with five known compounds (6-10) were isolated from the leaves of Chrysophyllum roxburghii G.Don. Their chemical structures were elucidated by extensive spectroscopic data analyses including IR, HR-ESI-MS, 1D and 2D NMR). Compounds 1, 3, and 5 showed cytotoxic effects against KB, HepG2, HL60, P388, HT29, and MCF7 cell lines with the IC50 values ranging from 14.40 to 52.63 µM compared to the positive control compound (ellipticine) with the IC50 values ranging from 1.34 to 1.99 µM.


Asunto(s)
Antineoplásicos Fitogénicos , Antineoplásicos , Saponinas , Triterpenos , Saponinas/farmacología , Saponinas/química , Triterpenos/farmacología , Triterpenos/química , Estructura Molecular , Glicósidos/farmacología , Glicósidos/química , Antineoplásicos Fitogénicos/farmacología , Antineoplásicos Fitogénicos/química
2.
Chem Biodivers ; 20(9): e202301090, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-37563096

RESUMEN

A phytochemical investigation of the methanolic extract of the Macropanax membranifolius C.B. Shang leaves led to the isolation of three new flavans, (2R,3R)-4'-O-methylcatechin 5-O-ß-D-glucopyranoside (1), (2S,3S)-4'-O-methylcatechin 5-O-ß-D-glucopyranoside (2), (2S,3R)-4'-O-methylcatechin 5-O-ß-D-glucopyranoside (3), one new triterpene glycoside 3-O-ß-D-xylopyranosyl-(1→6)-[ß-D-xylopyranosyl-(1→2)]-ß-D-glucopyranosyl-oleanolic acid 28-O-ß-D-glucopyranoside (4), together with nine known compounds (5-13). Their chemical structures were elucidated based on HR-ESI-MS, NMR spectroscopic data. The absolute configurations of compounds 1-3 were established by electronic circular dichroism (ECD) spectra. At concentration of 20 µM, compounds 1-13 showed the percentages of dead cell in the range of 2.14 % to 33.61 % against KB, HepG2, HL60, P388, HT29, and MCF7 cancerous cell lines by SRB assay.


Asunto(s)
Antineoplásicos , Saponinas , Triterpenos , Saponinas/química , Glicósidos/química , Espectroscopía de Resonancia Magnética , Extractos Vegetales/farmacología , Extractos Vegetales/química , Triterpenos/farmacología , Triterpenos/química , Estructura Molecular
3.
Pacing Clin Electrophysiol ; 30(9): 1165-7, 2007 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-17725764

RESUMEN

Cardiac resynchronization therapy (CRT) is a validated treatment for selected heart failure patients who remain highly symptomatic despite optimal drug treatment. Yet there is currently no indication for CRT in patients with few or no symptoms. We report a spectacular "reverse remodeling" effect after CRT in an asymptomatic patient with hypokinetic dilated myocardiopathy who needed pacing for atrio-ventricular conduction disorder. CRT was chosen to prevent deterioration of left ventricular function by conventional right apical pacing. Thus, CRT could be indicated in patients with hypokinetic dilated myocardiopathy before the appearance of symptoms.


Asunto(s)
Estimulación Cardíaca Artificial/métodos , Cardiomiopatía Dilatada/complicaciones , Cardiomiopatía Dilatada/prevención & control , Disfunción Ventricular Izquierda/complicaciones , Disfunción Ventricular Izquierda/prevención & control , Anciano , Humanos , Masculino , Resultado del Tratamiento , Remodelación Ventricular
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...