RESUMEN
In November 2013, national public health agencies in England and Scotland identified an increase in laboratory-confirmed Salmonella Mikawasima. The role of proton pump inhibitors (PPIs) as a risk factor for salmonellosis is unclear; we therefore captured information on PPI usage as part of our outbreak investigation. We conducted a case-control study, comparing each case with two controls. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression. Thirty-nine of 61 eligible cases were included in the study. The median age of cases was 45 years; 56% were female. Of these, 33% were admitted to hospital and 31% reported taking PPIs. We identified an association between PPIs and non-typhoidal salmonellosis (aOR 8·8, 95% CI 2·0-38·3). There is increasing evidence supporting the existence of an association between salmonellosis and PPIs; however, biological studies are needed to understand the effect of PPIs in the pathogenesis of Salmonella. We recommend future outbreak studies investigate PPI usage to strengthen evidence on the relevance of PPIs in Salmonella infection. These findings should be used to support the development of guidelines for patients and prescribers on the risk of gastrointestinal infection and PPI usage.
Asunto(s)
Brotes de Enfermedades , Inhibidores de la Bomba de Protones/administración & dosificación , Infecciones por Salmonella/epidemiología , Salmonella enterica/aislamiento & purificación , Adolescente , Adulto , Anciano , Estudios de Casos y Controles , Inglaterra/epidemiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Inhibidores de la Bomba de Protones/efectos adversos , Factores de Riesgo , Infecciones por Salmonella/inducido químicamente , Escocia/epidemiología , Gales/epidemiología , Adulto JovenRESUMEN
An increase in the number of cases of Shiga toxin-producing Escherichia coli O157 PT 2 stx2 infection was reported in the United Kingdom on 9 September 2013. Of the 19 cases, 13 were interviewed, of which 10 reported consuming watercress purchased from one retailer. The retailer recalled pre-packed bagged salads containing watercress on 12 September. The descriptive epidemiology was supported by a casecase study performed after control measures were implemented.
Asunto(s)
Brotes de Enfermedades , Infecciones por Escherichia coli/epidemiología , Escherichia coli O157/aislamiento & purificación , Enfermedades Transmitidas por los Alimentos/epidemiología , Escherichia coli Shiga-Toxigénica/aislamiento & purificación , Verduras/microbiología , Adolescente , Adulto , Anciano , Técnicas Bacteriológicas/métodos , Infecciones por Escherichia coli/diagnóstico , Femenino , Manipulación de Alimentos , Microbiología de Alimentos , Enfermedades Transmitidas por los Alimentos/microbiología , Humanos , Lactante , Masculino , Análisis Multivariante , Vigilancia de la Población , Reino Unido/epidemiologíaRESUMEN
We report the preliminary findings of the investigation of an outbreak of foodborne Salmonella Bareilly. Between August and November 2010, there were 231 laboratory-confirmed reports of S. Bareilly in the United Kingdom. A casecontrol study showed that consumption of bean sprouts was significantly associated with illness. The investigation concluded that raising public awareness to ensure the correct preparation of raw bean sprouts during cooking was the principal means of preventing further cases.