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6.
Case Rep Dermatol ; 8(2): 207-209, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27721752

RESUMEN

Cases of malignant melanoma on thermal burn scars have occasionally been reported. We report a 78-year-old Japanese female with malignant melanoma on a thermal burn scar with an interval of more than 70 years. Our case reemphasizes the importance of regular examinations in persons with thermal burn scars.

7.
J Dermatol ; 43(2): 210-4, 2016 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-26198822

RESUMEN

Nivolumab, a blockade of programmed cell death 1, is now administrated for advanced malignant melanomas. Nivolumab-associated adverse events include organ-specific autoimmune disorders; autoimmune thyroid disease, vitiligo and insulin-dependent diabetes. However, predisposed persons are currently unknown. Here, we report serological aggravation of autoimmune thyroid disease in two cases receiving nivolumab: one with Hashimoto disease and another with probable subclinical Hashimoto disease. We should verify if nivolumab-related hypothyroidism and hyperthyroidism are predisposed to occur in euthyroid individuals with subclinical autoimmune thyroid disease.


Asunto(s)
Anticuerpos Monoclonales/efectos adversos , Enfermedad de Hashimoto/etiología , Anciano , Femenino , Enfermedad de Hashimoto/sangre , Enfermedad de Hashimoto/inmunología , Humanos , Masculino , Melanoma/secundario , Melanoma/terapia , Nivolumab , Glándula Tiroides/diagnóstico por imagen , Hormonas Tiroideas/sangre , Ultrasonografía
10.
J Dermatol ; 41(11): 1003-5, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25346302

RESUMEN

Recovery with milia may occur in bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and epidermolysis bullosa acquisita (EBA). Scarring commonly occurs in MMP and EBA. Here, we report a 62-year-old man patient with BP, who was left with numerous milia during recovery. The patient had immunoglobulin (Ig)G autoantibodies to the recombinant protein of the BP180-NC16a domain and the soluble 120-kDa ectodomain of BP180 (linear IgA bullous dermatosis [LAD]-1). There are cases of BP with IgG autoantibodies to LAD-1 and/or the recombinant protein of BP180 C-terminal domain. Extensive milia formation during recovery may be associated with immunological predisposition and/or improper interaction between hemidesmosomes and the extracellular matrix components.


Asunto(s)
Penfigoide Ampolloso/patología , Piel/patología , Humanos , Masculino , Persona de Mediana Edad , Penfigoide Ampolloso/tratamiento farmacológico
12.
Australas J Dermatol ; 54(3): e67-9, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22686592

RESUMEN

Patients with acquired haemophilia A usually show widespread subcutaneous bleeding. We describe an 86-year-old man with acquired haemophilia A associated with prostate carcinoma, showing initial localised giant haematoma and subsequent widespread subcutaneous bleeding. A localised giant haematoma may present as a first and important sign of acquired haemophilia A.


Asunto(s)
Carcinoma/diagnóstico , Hematoma/etiología , Hemofilia A/complicaciones , Hemofilia A/tratamiento farmacológico , Neoplasias de la Próstata/diagnóstico , Púrpura/etiología , Anciano de 80 o más Años , Carcinoma/complicaciones , Hematoma/tratamiento farmacológico , Hemofilia A/diagnóstico , Humanos , Masculino , Neoplasias de la Próstata/complicaciones , Púrpura/tratamiento farmacológico
13.
Case Rep Dermatol ; 4(1): 47-9, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-22529802

RESUMEN

Patients with hematologic malignancies are immunosuppressive and may develop cutaneous or invasive infections as a primary sign of immune suppression. Acute promyelocytic leukemia (acute myeloid leukemia M3) is caused by translocation of reciprocal chromosomal rearrangement t(15;17), which produces an oncogenic protein. We herein describe a 71-year-old man having cellulitis with leukocytopenia as a first sign of acute promyelocytic leukemia. Dermatologists and hematologists should keep in mind that patients with a hematologic malignancy, such as acute promyelocytic leukemia, can develop cellulitis with leukocytopenia.

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