Asunto(s)
Polipéptido Inhibidor Gástrico/sangre , Glucagón/sangre , Insulina/sangre , Islotes Pancreáticos/metabolismo , Trasplante de Páncreas/fisiología , Animales , Duodeno/trasplante , Prueba de Tolerancia a la Glucosa , Rechazo de Injerto , Islotes Pancreáticos/patología , Trasplante de Islotes Pancreáticos , Necrosis , Trasplante de Páncreas/patología , PorcinosRESUMEN
A randomized trial with a blind observer compared the efficacy of an emulsion containing micronized sucralfate (1 g four times daily) and ranitidine (150 mg twice daily) in the short-term healing of peptic ulcer. Patients with a minimum ulcer size of 5 mm located in the duodenal bulb, the pyloric canal, or in the prepyloric area within a distance of 2 cm from the pylorus were included. A total of 97 patients were randomized and 85 completed the trial. The endoscopically proven healing rate at 2 weeks of 41% for both sucralfate and ranitidine improved to 76% for sucralfate and 73% for ranitidine at 4 weeks and to 95% and 96%, respectively, at 12 weeks. The difference between the two treatment groups was not statistically significant, and the 95% confidence interval for the difference in ulcer healing efficacy of sucralfate emulsion compared with ranitidine was -0.15 to +0.21 at 4 weeks and -0.10 to +0.08 at 12 weeks.
Asunto(s)
Úlcera Péptica/tratamiento farmacológico , Ranitidina/uso terapéutico , Sucralfato/uso terapéutico , Adulto , Anciano , Anciano de 80 o más Años , Ensayos Clínicos como Asunto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Distribución AleatoriaRESUMEN
Experience gained in wartime surgery have made important contributions to the treatment of colon injuries. During World War I, when the method of treatment was primary closure, the mortality rate was 60-70%. In World War II, when, following the recommendation of Ogilvie (15), the preferred method of treatment was exteriorization or proxima colostomy, the mortality rate fell to 25-30%. Given such marked improvement it was inevitable that the practice of exteriorization would be applied to civilian life. In 1951 Woodhall and Ochsner (24) suggested a more selective approach to the treatment of large bowel injuries. Following their report other authors (5, 11, 12, 18) have reported favourable results with primary suture and resection of certain types of colon wounds. During hte last decade the mortality of ano-rectal injury has been further reduced mainly due to the use of a washout of the distal rectum, presacral drainage and proper use of antibiotics.
