RESUMEN
OBJECTIVE: The 13C-urea breath test (UBT) is the most widely used non-invasive diagnostic test for Helicobacter pylori. Debate continues to surround the possible interference of antacid intake on its result. This study aims to confirm the non-interference of almagate in the determination of H. pylori by UBT. PATIENTS AND METHODS: Observational, multicentre study in adult patients treated with almagate in whom a UBT (TAUKIT®) was indicated. When the UBT result was negative, use of almagate was stopped for 30 days and the UBT was repeated. When the result was positive, no further determinations were made. The primary endpoint was the percentage of patients who, having had a negative result in the first breath test, were positive in the second after having stopped taking almagate (UBT false negatives, possibly attributable to almagate). RESULTS: Of the 167 evaluable patients, 59% were female, average age was 49 and 97% had gastrointestinal symptoms. The result of the first UBT was negative in 71% of cases. Of these, in the second UBT test after stopping the almagate, the negative result was confirmed in 97.5%. Out of the total number of cases evaluated, the rate of false negatives was 1.8%. CONCLUSIONS: Taking almagate has minimal or no interference in the result of UBT for the diagnosis of H. pylori infection. It can therefore be used in the weeks prior to a UBT.
Asunto(s)
Hidróxido de Aluminio/administración & dosificación , Antiácidos/administración & dosificación , Pruebas Respiratorias/métodos , Carbonatos/administración & dosificación , Infecciones por Helicobacter/diagnóstico , Helicobacter pylori , Hidróxido de Magnesio/administración & dosificación , Hidróxido de Aluminio/efectos adversos , Antiácidos/efectos adversos , Pruebas Respiratorias/estadística & datos numéricos , Isótopos de Carbono , Carbonatos/efectos adversos , Dispepsia/tratamiento farmacológico , Reacciones Falso Negativas , Femenino , Reflujo Gastroesofágico/tratamiento farmacológico , Humanos , Hidróxido de Magnesio/efectos adversos , Masculino , Persona de Mediana Edad , España , Factores de Tiempo , UreaAsunto(s)
Riñón/patología , Liposarcoma/patología , Neoplasias Retroperitoneales/patología , Anciano , Anemia/etiología , Diafragma/patología , Diafragma/cirugía , Femenino , Humanos , Riñón/diagnóstico por imagen , Liposarcoma/complicaciones , Liposarcoma/diagnóstico por imagen , Liposarcoma/cirugía , Invasividad Neoplásica , Nefrectomía , Neoplasias Retroperitoneales/complicaciones , Neoplasias Retroperitoneales/diagnóstico por imagen , Neoplasias Retroperitoneales/cirugía , Esplenectomía , Tomografía Computarizada por Rayos XRESUMEN
Cystic pancreatic neuroendocrine tumors (cPNETs) represent less than 8% of all pancreatic cysts and approximately 13% of pancreatic endocrine tumors (PNETs). According to a recent review, the percentage of non-functional (NF) PNETs is 85% and 44.6% are incidentalomas. In our series of 75 PNET cases, ten cPNET cases (13%) were identified which are discussed and summarized below.
Asunto(s)
Neoplasias Quísticas, Mucinosas y Serosas/diagnóstico por imagen , Tumores Neuroendocrinos/diagnóstico por imagen , Neoplasias Pancreáticas/diagnóstico por imagen , Adulto , Endosonografía , Humanos , Hallazgos Incidentales , Masculino , Neoplasias Quísticas, Mucinosas y Serosas/cirugía , Tumores Neuroendocrinos/cirugía , Neoplasias Pancreáticas/cirugíaAsunto(s)
Tumores Neuroendocrinos/diagnóstico , Neoplasias Pancreáticas/diagnóstico , Protocolos Clínicos , Endosonografía , Gastrinoma/diagnóstico , Gastrinoma/diagnóstico por imagen , Gastrinoma/patología , Humanos , Insulinoma/diagnóstico , Insulinoma/diagnóstico por imagen , Insulinoma/patología , Imagen por Resonancia Magnética , Tumores Neuroendocrinos/diagnóstico por imagen , Tumores Neuroendocrinos/patología , Neoplasias Pancreáticas/diagnóstico por imagen , Neoplasias Pancreáticas/patología , Tomografía de Emisión de Positrones , Tomografía Computarizada por Rayos XRESUMEN
INTRODUCTION AND OBJECTIVE: pancreatic endocrine tumors (PET) are difficult to diagnose. Their accurate localization using imaging techniques is intended to provide a definite cure. The goal of this retrospective study was to review a PET series from a private institution. PATIENTS AND METHODS: the medical records of 19 patients with PETs were reviewed, including 4 cases of MEN-1, for a period of 17 years (1994-2010). A database was set up with ten parameters: age, sex, symptoms, imaging techniques, size and location in the pancreas, metastasis, surgery, complications, adjuvant therapies, definite diagnosis, and survival or death. RESULTS: a total of 19 cases were analyzed. Mean age at presentation was 51 years (range: 26-67 y) (14 males, 5 females), and tumor size was 5 to 80 mm (X: 20 mm). Metastatic disease was present in 37% (7/19). Most underwent the following imaging techniques: ultrasounds, computed tomography (CT) an magnetic resonance imaging (MRI). Fine needle aspiration punction (FNA) was performed for the primary tumor in 4 cases. Non-functioning: 7 cases (37%), insulinoma: 2 cases [1 with possible multiple endocrine neoplasia (MEN)], Zollinger-Ellison syndrome (ZES) from gastrinoma: 5 (3 with MEN-1), glucagonoma: 2 cases, 2 somatostatinomas; carcinoid: 1 case with carcinoide-like syndrome. Most patients were operated upon: 14/19 (73%). Four (4/14:28%) has postoperative complications following pancreatectomy: pancreatitis, pseudocyst, and abdominal collections. Some patients received chemotherapy (4), somatostatin (3) and interferon (2) before or after surgery. Median follow-up was 48 months. Actuarial survival during the study was 73.6% (14/19). CONCLUSIONS: age was similar to that described in the literature. Males were predominant. Most cases were non-functioning (37%). Most patients underwent surgery (73%) with little morbidity (28%) and an actuarial survival of 73.6% at the time of the study.