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Eur Spine J ; 16(4): 563-72, 2007 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-17024402

RESUMEN

Vascular changes after acute spinal cord trauma are important factors that predispose quadriplegia, in most cases irreversible. Repair of the spinal blood flow helps the spinal cord recovery. The average time to arrive and perform surgery is 3 h in most cases. It is important to determine the critical ischemia time in order to offer better functional prognosis. A spinal cord section and vascular clamping of the spinal anterior artery at C5-C6 model was used to determine critical ischemia time. The objective was to establish a critical ischemia time in a model of acute spinal cord section. Four groups of dogs were used, anterior approach and vascular clamp of spinal anterior artery with 1, 2, 3, and 4 h of ischemia and posterior hemisection of spinal cord at C5-C6 was performed. Clinical evaluation was made during 12 weeks and morphological evaluation at the end of this period. We obtained a maximal neurological coordination at 23 days average. Two cases showed sequels of right upper limb paresis at 1 and 3 ischemia hours. There was nerve conduction delay of 56% at 3 h of ischemia. Morphological examination showed 25% of damaged area. The VIII and IX Rexed's laminae were the most affected. The critical ischemia time was 3 h. Dogs with 4 h did not exhibit any recovery.


Asunto(s)
Isquemia/fisiopatología , Paresia/fisiopatología , Traumatismos de la Médula Espinal/fisiopatología , Médula Espinal/irrigación sanguínea , Enfermedad Aguda , Animales , Modelos Animales de Enfermedad , Perros , Isquemia/patología , Isquemia/cirugía , Degeneración Nerviosa/patología , Degeneración Nerviosa/fisiopatología , Degeneración Nerviosa/cirugía , Conducción Nerviosa , Paresia/patología , Recuperación de la Función , Médula Espinal/patología , Traumatismos de la Médula Espinal/patología , Traumatismos de la Médula Espinal/cirugía , Instrumentos Quirúrgicos , Factores de Tiempo
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