Repotrectinib in a Patient With NTRK Fusion-Positive Pancreatic Carcinoma and Congenital Long QT Syndrome.

Repotrectinib in a patient with NTRK fusion-positive pancreatic carcinoma and congenital long QT syndrome.

Role of affective reactivity induced by cigarette packaging including graphic warning labels: the CASA Study.

OBJECTIVE: To identify whether three types of cigarette pack designs, including three versions of graphic warning label (GWL) plain packs, one GWL absent and branding absent pack (blank) and the smoker's own GWL absent and branding present pack (US), elicit different valence, type and levels of affect. DESIGN: US daily smokers (n=324) were asked to handle each of the five pack types and 'think aloud' their reactions. To avoid a muted familiarity response, exposure to their own US pack followed exposure to at least one GWL plain pack. Reactions were scored on a reactivity scale (-3 to +3) and the text was coded for speech polarity (-1 to +1) and emotive word frequency. RESULTS: Reactivity scores had excellent inter-rater reliability (agreement ≥86%; intraclass correlation coefficient ≥0.89) and were correlated with speech polarity (r=0.21-0.37, p<0.001). When considering their US pack, approximately two-thirds of smokers had a low (31.5%) to medium (34.6%) positive response (reactivity=1.29; polarity=0.14) with expressed feelings of joy and trust. Blank packaging prompted a largely (65.4%) neutral response (reactivity=0.03; polarity=0.00). The gangrenous foot GWL provoked mostly medium (46.9%) to high (48.1%) negative responses (reactivity=-2.44; polarity=-0.20), followed by neonatal baby (reactivity=-1.85; polarity=-0.10) and throat cancer (reactivity=-1.76; polarity=-0.08) warnings. GWLs varied in their elicitation of disgust, anger, fear and sadness. CONCLUSION: Initial reactions to GWL packs, a blank pack, and smokers' current US pack reflected negative, neutral, and positive affect, respectively. Different versions of the GWL pack elicited different levels and types of immediate negative affect.

Green Nanocomposites Based on Thermoplastic Starch: A Review.

The development of bio-based materials has been a consequence of the environmental awareness generated over time. The versatility of native starch is a promising starting point for manufacturing environmentally friendly materials. This work aims to compile information on the advancements in research on thermoplastic starch (TPS) nanocomposites after the addition of mainly these four nanofillers: natural montmorillonite (MMT), organically modified montmorillonite (O-MMT), cellulose nanocrystals (CNC), and cellulose nanofibers (CNF). The analyzed properties of nanocomposites were mechanical, barrier, optical, and degradability. The most important results were that as the nanofiller increases, the TPS modulus and strength increase; however, the elongation decreases. Furthermore, the barrier properties indicate that that the incorporation of nanofillers confers superior hydrophobicity. However, the optical properties (transparency and luminosity) are mostly reduced, and the color variation is more evident with the addition of these fillers. The biodegradability rate increases with these nanocompounds, as demonstrated by the study of the method of burial in the soil. The results of this compilation show that the compatibility, proper dispersion, and distribution of nanofiller through the TPS matrix are critical factors in overcoming the limitations of starch when extending the applications of these biomaterials. TPS nanocomposites are materials with great potential for improvement. Exploring new sources of starch and natural nano-reinforcement could lead to a genuinely eco-friendly material that can replace traditional polymers in applications such as packaging.

Salud sexual reproductiva en estudiantes universitarios: conocimientos y prácticas / Sexual and reproductive health in university students: beyond knowledge and practices / Saúde sexual reprodutiva em estudantes universitários: conhecimentos e práticas

Objetivo: Describir el conocimiento y las prácticas relacionadas con la salud sexual y reproductiva en los estudiantes de una Universidad del suroccidente colombiano. Materiales y métodos: Investigación cuantitativa, descriptiva y prospectiva de corte transversal realizada con estudiantes matriculados en I y II semestre en el primer periodo académico 2016. El cálculo de la muestra se obtuvo utilizando la fórmula de varianza desconocida y población total conocida (3.489), obteniendo un tamaño de muestra de 415 estudiantes. Se utilizó un instrumento tipo encuesta estructurado a partir del formato de consejería del programa de salud sexual y reproductiva universitario. Los datos se procesaron a través de Excel y el paquete estadístico SPSS versión 22. Para determinar la significación de la asociación se utilizó la prueba Chi cuadrado con una confiabilidad de 95 %. Resultados: En la población estudiada se encontró un predominio masculino del 50,7 %, la edad promedio fue de 19 años, encontrando que el 81 % está en una etapa de adolescencia tardía, el 62 % tiene un nivel de conocimientos defi cientes sobre salud sexual y reproductiva, el 78 % inició vida sexual con edad promedio de 16 años, un gran porcentaje de estos estudiantes tiene entre 1 y 3 compañeros(as) sexuales al año. El 70 % utilizó condón en su primera relación sexual y el 12,3 % de la población utilizó la píldora de emergencia. Conclusiones: El nivel de conocimiento acerca de salud sexual y reproductiva es deficiente. La mayoría de los estudiantes encuestados utiliza al menos un método de planificación familiar en sus relaciones sexuales.

Objective: To describe the knowledge and practices related to Sexual and Reproductive Health in the students of a University of the Suroccidente Colombiano. Materials and methods: Quantitative descriptive prospective cross-sectional study; was carried out in students enrolled in I and II semester in the first academic period 2016; the calculation of the sample was obtained using the formula of unknown variance and known total population (3,489), obtaining a sample size of 415 students. A structured survey-type instrument was developed based on the counseling format of the university's sexual and reproductive health program. Data were processed through Excel and the SPSS version 22 statistical package, to determine the significance of the association was used Chi square test with a reliability of 95%. Results: A male prevalence of 50.7% was found in the study population, the mean age was 19 years, and 81% were in the late teens, 62% had a poor level of knowledge about sexual health and reproductive, 78% start sexual life with average age of 16 years, a large percentage of these students have between 1 and 3 sexual partners a year. Seventy percent used a condom at their first sexual intercourse and 12.3% of the population used the emergency pill. Conclusions: The level of knowledge about sexual and reproductive health is deficient. Most students surveyed use at least one method of family planning in their sexual relationships.

Objetivos: Descrever os conhecimentos e práticas relacionados com a saúde sexual e reprodutiva em estudantes de uma Universidado sudoeste Colombiano. Materiais e Métodos: A pesquisa quantitativa transversal descritiva prospectiva; foi realizado em estudantes matriculados em I e II, semestre 2016; cálculo da amostra foi obtida utilizando a fórmula de variância desconhecida e a população total conhecido (3489), obtendo-se um tamanho de amostra de 415 estudantes. Foi utilizado um tipo de instrumento de pesquisa estruturada. Os dados foram processados pelo pacote estatístico Excel versão 2010 e SPSS versão 22, para determinar o significado do teste foram utilizados do qui-quadrado de associação com uma confiabilidade de 95%. Resultados: Na população estudada predominância do sexo masculino de 50,7%, a idade média dos alunos era de 19 anos, descobrindo que 81% estão em uma fase de adolescência tardia, 62% têm um nível de conhecimentos regulares saúde sexual e reprodutiva, 78% inicio vida sexual com uma idade média de 16 anos, uma grande porcentagem desses estudantes estão entre 1 e 3 parceiro (s) ano sexual. 70% usam preservativo em sua primeira relação sexual e 12,3% da população usava a pílula de emergência. Conclusões: O nível de conhecimento sobre a saúde sexual e reprodutiva é regular. A maioria dos estudantes pesquisados usar pelo menos um método de planejamento familiar em suas relações sexuais.