1.
J Am Chem Soc
; 135(7): 2482-5, 2013 Feb 20.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23387331
RESUMEN
The effectiveness of a new asymmetric catalytic methodology is often weighed by the number of diverse substrates that undergo reaction with high enantioselectivity. Here we report a study that correlates substrate and ligand steric effects to enantioselectivity for the propargylation of aliphatic ketones. The mathematical model is shown to be highly predictive when applied to substrate/catalyst combinations outside the training set.