RESUMEN
UNLABELLED: Several studies show that cross-transmission of germs among patients under dialysis can occur as a consequence of processes in which the dialysis machine participates. The need of vascular access and lengthy periods of extracorporeal circulation increases the vulnerability to infection from nearby microorganisms. This study is intended to analyze the structural and dynamic features of the cross-transmission network generated by the propagation of germs which are capable of contaminating the hemodialyzers. METHODS: The simulation was carried out in a Dialysis Unit equipped with 19 machines for 62 patients. One of these patients was randomly chosen and considered as a carrier of an infectious agent capable of being transmitted to other patients, by means of the shared use of the same dialysis machine. For 10 days, the patient-machine allocation couples were registered. Co-occurrence matrices were elaborated and processed with the program UCINET 6.1 for social network analysis. Graphs were designed to visualize the networks of contagion, the centrality measures were calculated and the dynamic performance of the network generated by the chaining of the successive exposures of machines and patients was studied. RESULTS: The simulation let us visualize a rapid expansion of the risk of contagion of patients and contamination of machines. In 10 days, 87,09% of patients could have been exposed to the infection, and 68,42% of the machines could have been contaminated. These figures supposes that 5,4 new patients and 1,3 new machines could be potentially exposed every day. Along the first 5 days, the daily rate of exposure for patients and machines remains relatively low (3 new exposed patients and 1,2 new exposed machines every day). But the speed with witch the risk of contagion spreads, increases drastically in the last 5 days (7,8 new exposed patients every day). The fact that each patient requires at least 3 weekly sessions of dialysis and that a different machine can be allocated to him in each session explains that the risk of exposure can spread in some few days to a lot of patients and machines. It can also explain the difficulties found by the researches in identifying the responsible source of the origin of the sero-conversion outbreaks studied by the moment. CONCLUSIONS: If a germ can be transmitted from patient to patient by means of the incidental contamination of a dialysis machine, the appearance of an infected patient in a dialysis unit generates a risk of exposition that spreads quickly among other patients. Few days after an infected patient gets a dialysis session, it cannot be ruled out that most of the patients have been exposed to contagion and most of the machines exposed to contamination.
Asunto(s)
Infección Hospitalaria/epidemiología , Modelos Teóricos , Diálisis Renal , Humanos , Factores de RiesgoRESUMEN
UNLABELLED: We describe the infection by HIV observed in the scope of the Military Hospital and we evaluate the clinical usefulness of the current classification systems. We have retrospectively studied (1986-1993) 80 confirmed cases of infection by HIV: 21 women and 59 men (age range: 17-65 years). Quarterly clinico-biological controls. Initial and final classification according to CDC 87/93 systems. STATISTICAL ANALYSIS: RSIGMA. We have detected in 26% of the patients heterosexual contagion; in 55%, toxicomania and in 17%, homosexuality; 39% had less than 200 CD4/microL upon admission. During the follow-up, 35 patients fulfilled AIDS criteria (17% due to tuberculosis); 17 died (21%) and 30 gave up (37%). CONCLUSIONS: HIV infection is less frequent in the military sociofamiliar environment, with lower incidence of tuberculosis. There is a greater proportion of women, heterosexual transmission and asymptomatic patients. CDC-93 classification is the system best adapted to the natural history of the HIV infection.
