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1.
Med Hypotheses ; 133: 109382, 2019 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-31470243

RESUMEN

The essence of our hypothesis is quantum properties of conscious processes as well as the possibility to measure changes in conscious attention by using quantum double-slit experiment. We supposed that the act of observing in state of focused attention cause a wave function collapse in double-slit diffraction. In order to test the hypothesis, 26 participants took part in the study divided into physical and physiological parts of the experiment. The purpose of the physical system was to reproduce the brain quantum process via hypothesized quantum entanglement. The physical part consisted of a red laser source, neutral density filter, double-slit diaphragm, and linear couple charged camera, while the physiological part of the experiment was significant for the physiological quantifying state of attention. Physiological data were collected by using 29 channel electrophysiological unit with 21 channel electroencephalograph. The study had control and experimental group according to dependent variables measured in the physical part of the experiment. The data in the experimental group were collected over ten studies (sessions). Results obtained in hypothesis testing showed significant increases in corpuscular properties of the electromagnetic wave as well as significant quantum entanglement between the brain and external double-slit quantum system. Our results also offer insight into the connection between the chaotic dynamic of the electroencephalographic signals and uncertainty in the physical system due to focused attention effect. We also hypothesized that the state of concentrated attention was highest during the first several seconds. The last hypothesis considered possible backward time referral effect of cognitive evoked potential p300.


Asunto(s)
Estado de Conciencia/fisiología , Electroencefalografía , Modelos Neurológicos , Modelos Psicológicos , Teoría Cuántica , Adulto , Nivel de Alerta/fisiología , Atención/fisiología , Entropía , Potenciales Relacionados con Evento P300/fisiología , Humanos , Dinámicas no Lineales , Incertidumbre
2.
World J Gastroenterol ; 18(4): 331-9, 2012 Jan 28.
Artículo en Inglés | MEDLINE | ID: mdl-22294839

RESUMEN

AIM: Тo examine the effects of nitroglycerine on portal vein haemodynamics and oxidative stress in patients with portal hypertension. METHODS: Thirty healthy controls and 39 patients with clinically verified portal hypertension and increased vascular resistance participated in the study. Liver diameters, portal diameters and portal flow velocities were recorded using color flow imaging/pulsed Doppler detection. Cross-section area, portal flow and index of vascular resistance were calculated. In collected blood samples, superoxide anion radical (O(2) (-)), hydrogen peroxide (H(2)O(2)), index of lipid peroxidation (measured as TBARS) and nitric oxide (NO) as a marker of endothelial response (measured as nitrite-NO(2) (-)) were determined. Time-dependent analysis was performed at basal state and in 10th and 15th min after nitroglycerine (sublingual 0.5 mg) administration. RESULTS: Oxidative stress parameters changed significantly during the study. H(2)O(2) decreased at the end of study, probably via O(2) (-) mediated disassembling in Haber Weiss and Fenton reaction; O(2) (-) increased significantly probably due to increased diameter and tension and decreased shear rate level. Consequently O(2) (-) and H(2)O(2) degradation products, like hydroxyl radical, initiated lipid peroxidation. Increased blood flow was to some extent lower in patients than in controls due to double paradoxes, flow velocity decreased, shear rate decreased significantly indicating non Newtonian characteristics of portal blood flow. CONCLUSION: This pilot study could be a starting point for further investigation and possible implementation of some antioxidants in the treatment of portal hypertension.


Asunto(s)
Hipertensión Portal/fisiopatología , Nitroglicerina/farmacología , Estrés Oxidativo/efectos de los fármacos , Vena Porta/efectos de los fármacos , Vena Porta/fisiología , Vasodilatadores/farmacología , Adulto , Femenino , Hemodinámica/efectos de los fármacos , Humanos , Peróxido de Hidrógeno/metabolismo , Peroxidación de Lípido , Masculino , Persona de Mediana Edad , Óxido Nítrico/metabolismo , Oxidantes/metabolismo , Proyectos Piloto , Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismo
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