Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
Más filtros












Base de datos
Intervalo de año de publicación
1.
AIDS Care ; 35(8): 1215-1223, 2023 08.
Artículo en Inglés | MEDLINE | ID: mdl-33745403

RESUMEN

Chronic pain is a common comorbidity in people with HIV (PWH), with prevalence estimates of 25-85%. Research in this area is growing, but significant gaps remain. A Global Task Force of HIV experts was organized to brainstorm a scientific agenda and identify measurement domains critical to advancing research in this field. Experts were identified through literature searches and snowball sampling. Two online questionnaires were developed by Task Force members. Questionnaire 1 asked participants to identify knowledge gaps in the field of HIV and chronic pain and identify measurement domains in studies of chronic pain in PWH. Responses were ranked in order of importance in Questionnaire 2, which was followed by a group discussion. 29 experts completed Questionnaire 1, 25 completed Questionnaire 2, and 21 participated in the group. Many important clinical and research priorities emerged, including the need to examine etiologies of chronic pain in PWH. Pain-related measurement domains were discussed, with a primary focus on domains that could be assessed in a standardized manner across various cohorts that include PWH in different countries. We collaboratively identified clinical and research priorities, as well as gaps in standardization of measurement domains, that can be used to move the field forward.


Asunto(s)
Dolor Crónico , Infecciones por VIH , Humanos , Infecciones por VIH/complicaciones , Infecciones por VIH/epidemiología , Dolor Crónico/epidemiología , Comorbilidad
2.
Genes Immun ; 14(4): 268-70, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23486014

RESUMEN

Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies.


Asunto(s)
Población Negra/genética , Haplotipos , Factores de Necrosis Tumoral/genética , Pueblo Asiatico/genética , Estudios de Casos y Controles , Humanos , Polimorfismo de Nucleótido Simple , Población/genética , Sudáfrica , Población Blanca/genética
3.
Mol Immunol ; 55(3-4): 197-9, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23511027

RESUMEN

INTRODUCTION: Animal and in vitro models of HIV-associated sensory neuropathy suggest an inflammatory etiology. Previous genetic association studies of HIV-SN have been in small Caucasian or Asian cohorts. We assessed cytokine single nucleotide polymorphisms (SNPs) in a Black Southern African cohort. METHOD: 342 black HIV-positive Southern Africans were recruited. 190 individuals had HIV-associated sensory neuropathy and 152 did not. DNA samples from all participants were genotyped for cytokine SNPs identified in studies of HIV disease and/or neuropathy. RESULTS: IL4-590*T associated with an increased prevalence of HIV-SN including following correction for age, height and CD4 T-cell count. No other cytokine SNPs assessed displayed an association. DISCUSSION: We identified a novel association between IL4-590*T and HIV-SN in African HIV-positive patients which warrants further investigation.


Asunto(s)
Infecciones por VIH/genética , Infecciones por VIH/inmunología , Interleucina-4/genética , Enfermedades del Sistema Nervioso Periférico/genética , Enfermedades del Sistema Nervioso Periférico/inmunología , Polimorfismo de Nucleótido Simple , Población Negra/genética , Estudios de Cohortes , Frecuencia de los Genes , Estudios de Asociación Genética , Infecciones por VIH/epidemiología , Humanos , Enfermedades del Sistema Nervioso Periférico/epidemiología , Prevalencia , Sudáfrica
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...