High-carbon expansion or low-carbon intensive and mixed land-use? Recent observations from megacities in developing countries: A case study of Shanghai, China.

Cities have become significant sources of greenhouse gas emissions. Effective land management may be the solution to carbon neutrality targets for megacities with limited land resources. This paper takes Shanghai as a case study to investigate the regional land use dynamics and its impact on carbon emissions following the implementation of land conservation and intensive use policy. During 2010-2020, the land use pattern in Shanghai changed from the previous urban land expansion to a combination of industrial land reduction and woodland expansion. Meanwhile, the area proportion of land-use mixture grids increased from 90.50% to 92.28% with the spatial pattern of mixed types also changing. Furthermore, the notable land-use mixture does not necessarily lead to carbon emission reduction, but it can reduce carbon emission hotspots in industrial agglomerations by promoting the mixed use of industrial land and other land use types. However, megacities cannot achieve carbon balance through land use management alone. Due to the increasing carbon emission density of hybrid industrial land, the joint implementation of a land conservation and intensive use strategy with industrial and energy structure adjustments may be an effective way forward.

Cap-assisted endoscopic sclerotherapy is effective for rectal mucosal prolapse associated outlet obstructive constipation.

BACKGROUND AND STUDY AIMS: Outlet obstructive constipation (OOC) is a common type of chronic constipation that is usually caused by internal hemorrhoids (IH) and rectal mucosal prolapse (RMP). Cap-assisted endoscopic sclerotherapy (CAES) was demonstrated to be effective in the treatment of IH and RMP. This study explored the efficacy of CAES in treating OOC associated with IH and RMP. METHODS: Thirty-one patients (15 males and 16 females) were diagnosed with OOC after colonoscopy and anorectal manometry (AM). CAES was used to treat IH and RMP. The self-rating anxiety scale (SAS), self-rating depression scale (SDS), and Wexner constipation score (WCS) were used to assess patients at baseline and at the end of follow-up. AM tests were performed before and after CAES. RESULTS: The mean age of patients was 56.19 ± 7.969 years, and the follow-up time was 2.875 ± 3.703 months. After CAES treatment, subjective indices, including frequency of bowel movements (p < 0.05), defecation time (p < 0.05), SAS (p < 0.05), SDS (p < 0.05), and WCS (p < 0.05), were significantly improved. AM showed that the anal relaxation rate (p < 0.05), maximum squeeze pressure (p < 0.05), and rectal residual pressure (p < 0.05) were significantly improved. The ratio of Bristol stool form scale typeIII-Vincreased from 12.5 % to 56.25 % (p < 0.05). CONCLUSIONS: CAES is effective for treating OOC caused by IH and RMP. The relief of OOC symptoms could improve anxiety and depression symptoms associated with the disease.

Bismuth oxide modified V2C MXene as a Schottky catalyst with enhanced photocatalytic oxidation for photo-denitration activities.

In this work, a new composite photocatalyst was synthesized by flower-like Bi2O3 and two-dimensional multilayer V2C using a facile hydrothermal method. Compared with the pristine sample, the specific surface area of Bi2O3/V2C MXene composite is significantly increased, which is favourable to improve the photocatalytic efficiency. The analysis of the UV-vis absorption spectrum and band gap energy shows that the construction of heterojunction broadens the light response range, improves the light absorption capacity, and obtains a narrower band gap than any of the single component, which is beneficial to the utilization of light. PL, TPC and EIS analysis revealed that Bi2O3/V2C MXene composite had stronger carrier mobility, which further confirmed that the photocatalytic oxidation performance of the system was the dominant reason in the photocatalytic NO pollutant removal process. This study provides a new idea for better understanding the two-dimensional MXene material-based photocatalyst and improving the NO removal efficiency.

Numerical simulation of foundation pit dewatering using horizontal seepage reducing body.

Groundwater level has to be lowered during deep excavation. A vertical curtain is usually adopted to control the drawdown inside and outside a foundation pit in a built-up area. However, the cost and working difficulty increases substantially with the rise in depth of vertical curtains. In the manuscript, a man-made horizontal seepage reducing body (HSRB) was introduced to shorten the vertical curtain depth and control drawdown. With the No. 4 shaft foundation pit of Guangyuan Project, Shanghai as background, HSRB was proposed in foundation pit dewatering. Microbially induced carbonate precipitation grouting technology was recommended to form an environment-friendly HSRB. Numerical method was used to simulate and understand the influence of position, thickness, and hydraulic conductivity of HSRB on groundwater level. The non-separated HSRB was better than the separate HSRB. Decreasing HSRB hydraulic conductivity was better than increasing HSRB depth. Four seepage modes were summarized considering vertical curtain penetration conditions into multi-aquifer, and the fifth seepage mode was formed for vertical curtain using man-made HSRB, which can be referred by similar engineering applications.

Gastroesophageal reflux disease and salivary pepsin in patients with heterotopic gastric mucosa in the upper esophagus.

BACKGROUND: Heterotopic gastric mucosa in the upper esophagus (HGMUE) is reported to be related to gastroesophageal reflux disease (GERD). This study investigated the prevalence of GERD and the use of salivary pepsin to diagnose gastroesophageal reflux, especially proximal reflux, in HGMUE patients. METHODS: One hundred and fifty-three HGMUE patients and 50 healthy volunteers were studied. All subjects took a reflux symptom index questionnaire (RSI); underwent endoscopy, barium esophagogram, high-resolution manometry (HRM), and 24-hour multichannel intraluminal impedance-pH-metry (MII-pH); and salivary pepsin test. RESULTS: Ninety-five (62.1%) HGMUE patients but no control subjects were diagnosed with GERD. The salivary pepsin concentration, RSI score, DeMeester score, acid exposure time (AET), total reflux episodes, proximal acidic reflux episodes, and proximal weakly acidic reflux episodes were significantly higher in the HGMUE group than in the control group (P < 0.05). The salivary pepsin test showed a sensitivity of 85.9% and specificity of 56.9% for diagnosing GERD using the optimal cut-off value of 75 ng/mL. One hundred and seven (69.9%) and 46 (30.1%) HGMUE patients were categorized as pepsin (+) and pepsin (-), respectively when 75 ng/mL was used as a cut-off value. Male sex, RSI, AET, and proximal acid reflux episodes were positive predictive factors for the occurrence of pepsin (+) in HGMUE patients. CONCLUSIONS: GERD, especially GERD with proximal acid reflux and related symptoms, was common in HGMUE patients. The salivary pepsin test could be an additional useful test for testing reflux in HGMUE patients, but it will not replace the MII-pH.

circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR­199­3p expression.

Glioblastoma (GBM) is one of the most common and malignant types of primary cancer in the central nervous system; however, the clinical outcomes of patients with GBM remain poor. Circular RNAs (circRNAs) have been revealed to serve important roles in diverse biological processes, such as regulating cell proliferation, epithelial­mesenchymal transition and tumor development. However, the underlying biological function of circRNA filamin A (circFLNA) and its potential role in GBM remain to be determined. The present study aimed to identify differentially expressed circRNAs in GBM. Reverse transcription­quantitative PCR was used to analyze the expression levels of circFLNA. The results demonstrated that the expression levels of circFLNA were significantly upregulated in clinical GBM samples and GBM cells compared with adjacent healthy brain tissues and normal human astrocytes, respectively. The results of the Cell Counting Kit­8 and Transwell assays revealed that circFLNA knockdown significantly inhibited the proliferative and invasive abilities of GBM cell lines. Moreover, high circFLNA expression levels were associated with a worse prognosis in GBM. MicroRNA (miR)­199­3p was subsequently predicted to be target of circFLNA. The inhibitory effect of miR­199­3p on cell proliferation and invasion was partially reversed following circFLNA knockdown. In conclusion, the findings of the present study identified novel roles for circFLNA in GBM and indicated that the circFLNA/miR­199­3p signaling axis may serve an important role in GBM progression. Therefore, circFLNA may represent a novel target for the diagnosis and treatment of GBM.

Ethanol Extracts of Solanum lyratum Thunb Regulate Ovarian Cancer Cell Proliferation, Apoptosis, and Epithelial-to-Mesenchymal Transition (EMT) via the ROS-Mediated p53 Pathway.

Ovarian cancer is a type of common gynecological tumors with high incidence and poor survival. The anticancer effects of the traditional Chinese medicine Solanum lyratum Thunb (SLT) have been intensively investigated in various cancers but in ovarian cancer is rare. The current study is aimed at investigating the effect of SLT on ovarian cancer cells. Lactate dehydrogenase (LDH) and MTT assays indicated that SLT concentrations of 0.25 and 0.5 µg/mL were not cytotoxic and had significant inhibitory effects on the cell viabilities of A2780 and SKOV3 cells, hence were used for subsequent experiments. Flow cytometric and western blot analysis revealed that SLT effectively suppressed ovarian cancer cell proliferation via inducing cell cycle arrest and increasing apoptosis. Cell cycle and apoptosis-related protein expressions were also regulated in SLT-treated cells. Moreover, DCFH-DA and western blot assays demonstrated that SLT enhanced ROS accumulation and subsequently activated the p53 signaling pathway. However, SLT-regulated ovarian cancer cell proliferation, apoptosis, migration, invasion, and EMT were significantly reversed by an ROS inhibitor (NAC, N-acetyl-L-cysteine). Furthermore, A2780 and SKOV3 cells cocultured with M0 macrophages showed that SLT activated the polarization of M0 macrophages to M1 macrophages and inhibited the polarization to M2 macrophages, with the increased percentage of CD86+ cells and decreased percentage of CD206+ cells were detected. In summary, this study illustrated the anticancer effects of SLT on ovarian cancer cells, suggesting that SLT may have the potential to provide basic evidence for the discovery of antiovarian cancer agents.

Transient delayed gastric emptying following laparoscopic Nissen fundoplication for gastroesophageal reflux disease.

PURPOSE: Although laparoscopic Nissen fundoplication (LNF) is a kind of minimally invasive surgery, some transition time may still be required to allow the fundoplicated stomach to adapt to the new anatomical position. We observed transient delayed gastric emptying (DGE) post-LNF in our preliminary study. This study aimed to investigate the occurrence rate and development of transient DGE post-LNF. METHODS: Patients who underwent LNF for gastroesophageal reflux disease (GERD) at our institution were recruited consecutively. They were treated with standardized LNF and prospectively followed up for 2 months. Proper diet guidance and/or pharmacologic therapy were given during these 2 months. GERD Health-Related Quality of Life (GERD-HRQL), DGE symptoms, and DGE status were evaluated preoperatively and postoperatively. RESULTS: Fifty-one patients underwent LNF and completed a 2-month follow-up. LNF succeeded in all patients. Prior to LNF, no DGE was identified. At the 1-month follow-up, LNF led to a significant reduction in the GERD-HRQL total score but a significantly increased DGE score. Endoscopically, DGE was identified in forty-seven (n = 47, 92.2%) patients. At the 2-month follow-up, the GERD-HRQL scores continued to show decreases compared to the 1 month. The DGE score returned to the baseline value. Endoscopically, no DGE was identified in any patients (n = 0, 0.0%). CONCLUSIONS: Transient DGE is a very common one-month post-LNF but can recover quickly in the second month following LNF.

0D/2D Heterojunctions of Ti3C2 MXene QDs/SiC as an Efficient and Robust Photocatalyst for Boosting the Visible Photocatalytic NO Pollutant Removal Ability.

In this work, a novel heterojunction catalyst was constructed by introducing Ti3C2 MXene quantum dots (QDs) into SiC. The Ti3C2 MXene QDs/SiC composite showed 74.6% efficiency in NO pollutant removal under visible light irradiation, which is 3.1 and 3.7 times higher than those of the bare Ti3C2 MXene quantum dots and SiC, respectively. The Ti3C2 MXene quantum dots existing in SiC can function as a channel for electron and hole transfer. The enhanced visible light absorption, increased superoxide radical, and strong oxidization ability endow the Ti3C2 MXene QDs/SiC composite with a superior photocatalytic performance for NOx removal. The increased superoxide radical formation and enhanced oxidization ability of Ti3C2 MXene QDs/SiC were demonstrated by theoretical calculations. The robust stability in both photocatalytic performance and crystal structures was revealed in the Ti3C2 MXene QDs/SiC composite using the cycling test, transient photocurrent response, XRD, and TG.

Stretta procedure versus proton pump inhibitors for the treatment of nonerosive reflux disease: A 6-month follow-up.

To compare the Stretta procedure with proton pump inhibitors for the treatment of nonerosive reflux disease (NERD).From July 2018 to April 2019, patients diagnosed with NERD and referred for treatment were enrolled. They were treated with either Stretta procedure or proton pump inhibitor (PPI) medication and followed-up for 6 months. The symptom control, quality of life, lower esophageal sphincter (LES) pressure, 24-hour pH parameters, PPI usage and satisfaction rate were evaluated. The complications were assessed. The outcomes of the 2 groups were analyzed and compared.Twenty-eight patients in the Stretta group and 21 patients in the PPI group completed the 6-month follow-up. No severe adverse events occurred in both groups. Both interventions were effective in improvement of symptom and quality of life. The symptom score improvement was significantly superior in the Stretta group compared to the PPI group (6.3 ±â€Š3.4 vs 8.5 ±â€Š4.1, P = .03). LES pressure increased significantly in the Stretta group compared to the PPI group (14.2 ±â€Š4.4 mm Hg vs 10.0 ±â€Š4.0 mm Hg, P < .01). Although both interventions improved 24-hour pH parameters, including number of acid episodes (P = .27), acid exposure time (P = .39), and DeMeester score (P = .28), no difference was found between the 2 groups. Complete PPI cessation rate (82% vs 52%, P = .03) as well as satisfaction rate (89% vs 57%, P = .02) was much higher in Stretta group than those in the PPI groupThe Stretta procedure was safe and effective in the short term for the management of NERD. The Stretta procedure resulted in higher LES pressure and achieved better improvement of symptom control and PPI cessation than did PPI in the short term.

MIL-100(Fe)/Ti3C2 MXene as a Schottky Catalyst with Enhanced Photocatalytic Oxidation for Nitrogen Fixation Activities.

A new microporous MIL-100(Fe)/Ti3C2 MXene composite was constructed as a non-noble metal-based Schottky junction photocatalyst with improved nitrogen fixation ability. Ti3C2 MXene nanosheets exhibited excellent metal conductivity and were employed as two-dimensional support to optimize the composite's energy band structure. MIL-100(Fe) with a large specific surface area was used as an adsorbent and a photocatalytic oxidation center. The MIL-100(Fe)/Ti3C2 MXene composite not only exhibited higher thermal stability but also showed significantly increased nitrogen fixation activity under visible light. The NO conversion rate of the composite catalyst was about four and three times higher than that of the pure Ti3C2 MXene and the pure MIL-100(Fe) samples, respectively. Although adsorption plays an important role in the nitrogen fixation process, the synergistic effects of the Schottky junctions are the main cause of the enhanced photocatalytic activity. The built-in electric field can be generated to form charge-transfer channels, which help to achieve a desirable photocatalytic activity.

Association of conventional risk factors for cardiovascular disease with IMT in middle-aged and elderly Chinese.

To study the association between known risk factors for cardiovascular disease and intima-media thickness (IMT) in the carotid and popliteal arteries in middle-aged and elderly Chinese adults. 686 middle aged and elderly Chinese adults from the China Da Qing Diabetes Prevention Study who had full clinical, laboratory, ultrasound examination results were enrolled in the study. Common carotid artery (CCA) and popliteal artery (PA) IMT were obtained using high resolution ultrasound machine. Pearson's or Spearman's correlation analysis and logistic regression analysis were used to determine association between risk factors [age, gender, tobacco smoking, body mass index (BMI), diabetes mellitus (DM), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol, total triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, glycosylated hemoglobin (HbA1c)] and CCA- or PA-IMT. The age range of the study population was 45-87 years, 384 of them (56 %) were women. The prevalence of high blood pressure and DM was 60.6 and 68.8 %, respectively. Participants in DM group tended to be older, had greater value for SBP, HbA1c and PA-IMT, but smaller value for DBP than those in control group. Smoke status, BMI, blood lipids and CCA-IMT were not statistically different between groups. Pearson's or Spearman's rank correlation analysis showed that CCA-IMT had a positive correlation with age, gender, DM, SBP, BMI and HbA1c, negative correlation with HDL-C. PA-IMT showed a positive correlation with age, gender and SBP. Univariate logistic regression analysis showed that elevation of age, SBP, BMI, HbA1c and having DM were significant predictors of CCA-IMT thickening, so was reduction of HDL-C. Risk factors that predicted significant thickening of PA-IMT were age, gender, tobacco smoking. After adjusted for age and gender, except HDL-C, the other four risk factors (SBP, BMI, HbA1c and having DM) that predicted CCA-IMT thickening remained significant; however none of the risk factors predicted PA-IMT thickening after adjusted for age and gender. The current results provide evidence that CCA-IMT is a superior marker for atherosclerosis compared with PA-IMT. Aggressive control of SBP, HbA1c and proper control of weight may postpone thickening of CCA-IMT.

Assessment of global and regional left ventricular function after surgical revascularization in patients with coronary artery disease by real-time triplane echocardiography.

OBJECTIVE: The purpose of this study was to evaluate the capability of real-time triplane echocardiography (RT3PE) for monitoring global and regional systolic function of the left ventricle (LV) after surgical revascularization and for evaluating the effect of surgery and predicting restenosis. METHODS: Forty-nine patients underwent RT3PE before and at 10 days and 1, 3, and 6 months after coronary artery bypass grafting (CABG). The global systolic function of the LV was assessed with the parameters of end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and stroke volume (SV). The regional myocardial deformation was detected by triplane strain rate imaging. Recovery of myocardial function after surgery and the correlation between global and regional function were investigated. RESULTS: In 41 of the 49 patients, the EDV and ESV decreased, and the EF and SV increased gradually and showed statistical significance at 3 and 6 months after surgery (P < .05; P < .01). The systolic strain rate (SR(sys)) and systolic strain (S(sys)) increased, and the postsystolic strain index (PSI) decreased progressively after CABG, with significant changes in almost all studied segments at 6 months (P < .05; P < .01). In addition, recovery of the SR(sys), S(sys), and PSI at each follow-up stage after surgery correlated well with EF improvement, with a positive correlation between the SR(sys), S(sys), and EF and a negative correlation between the PSI and EF. Restenosis was suspected in the other 8 patients. The sensitivity, specificity, and accuracy of RT3PE to predict restenosis were 75.00%, 89.47%, and 85.19%, respectively. CONCLUSIONS: Real-time triplane echocardiography can be used to quantitatively assess global and regional myocardial function. It may represent a new, powerful method to monitor improvement of myocardial function after CABG and to predict restenosis.

Study of normal Chinese vertebral-basilar arteries with transcranial color Doppler flow imaging.

OBJECTIVE: The aim of this study was to evaluate the blood flow characteristics of intracranial vertebral-basilar artery (V-BA) in healthy Chinese adults with transcranial color Doppler flow imaging (TCDFI) and provide reference values of healthy people of different ages and genders. METHODS: Three hundred healthy Chinese adults were divided into three groups based on their ages: Group I: 20-39 years, Group II: 40-59 years, Group III: >/=60 years. Each group was subdivided into two subgroups according to their gender. Peak systolic velocity (Ps), end-diastolic velocity (Vd), time average maximum velocity (TAMAX), pulsatility index (PI), and resistance index (RI) were measured from intracranial V-BA scanning. RESULTS: Ps, Vd, and TAMAX decreased with age, while PI and RI increased in all groups. Flow velocity in women was slightly higher than that of men, and there was significant differences in group III between men and women (P<.05). However, no difference was found in the flow parameters between left and right vertebral arteries. CONCLUSIONS: This study offered reference values of intracranial V-BA flow parameters in healthy Chinese adults and indicated that these parameters varied with age and gender.