RESUMEN
Two undescribed polyacetylated 18-norspirostanol saponins, trilliumosides J (1) and 21-deoxyepitrillenoside C (2), a novel resveratrol aneuploid, 3a,3b-dimethoxyhopeachinol B (3) along with four known steroidal saponins (4-7), were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium camschatcense. The structures of isolated compounds were elucidated by spectroscopic analysis and chemical degradation. Compounds 1,3 and 4 had potential cytotoxic activity against MCF-7, with IC50 values 86.38 ± 2.59 µM, 56.20 ± 1.57 µM and 45.70 ± 0.63 µM.
RESUMEN
A new biflavone (philonotisflavone-3'''-methyl ether), three diterpenes (lupulin G, lupulin H, lupulin I), a new ecdysteroid (ajugasterone E), and four known compounds were isolated from the whole plant of Ajuga lupulina Maxim. Their structures were determined by spectroscopic analysis, including MS, NMR and ECD spectral data. Compounds 1-3 has DPPH radical scavenging ability, and compound 1 has stronger activity than vitamin C. Compounds 2, 3, 7 and 8 have potential cytotoxic activity against Hela, with IC50 values less than 20.0 µM. Abietane diterpenes 2, 3, 7 and 8 are also found to have NO inhibitory effects with IC50 values less than 40.0 µM.
RESUMEN
Four sesquiterpenoids A-D (1-4) were isolated from the ethanol extracts of the leaves and stems from Schisandra chinensis. Their structures and absolute configurations were elucidated by a combination of NMR, MS and ECD. Compounds 1-4 (10 µM) exhibited moderate hepatoprotective activities against APAP-induced LO2 cell damage with increasing cell viability by 18%, 17%, 16%, and 19% compared to the model group (bicyclol, 26%) at 10 µM, respectively. All the compounds displayed no cytotoxic activity against five human cell lines, which also suggested the safety of leaves and stems of S. chinensis as an edible vegetable in a degree.
